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Ocular-cerebral immune dialogue: a new perspective and therapeutic potential of regional lymphatic systems. [PDF]
Front ImmunolWang Y, Guo P, Li W, Li T.
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The meningeal lymphatic vasculature in neuroinflammation
The FASEB Journal, 2022Abstract The lymphatic vasculature is a unidirectional network of lymphatic endothelial cells, whose main role is to maintain fluid homeostasis along with the absorption of dietary fat in the gastrointestinal organs and management and coordination of immune cell trafficking into lymph nodes during homeostasis and under inflammatory ...
Alexandra Olate‐Briones +6 more
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Meningeal Lymphatic vasculature in health and disease
Current Opinion in Hematology, 2022Purpose of review The recent (re)discovery of the meningeal lymphatic has brought a new player in brain neurophysiology. This review highlights the state of the current research on the meningeal lymphatic vasculature, from its specific physiology to its increasing implication in normal and pathological brain function.
Nisha, Busch +2 more
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Meningeal lymphatics, immunity and neuroinflammation
Current Opinion in Neurobiology, 2020In the past five years, the surrounding of the brain, that is the meninges (singular meninx) have evolved from being a physical barrier that protects the brain parenchyma to becoming a central player for both the maintenance of normal brain function and the modulation of neurological disorders.
Natalie, Frederick, Antoine, Louveau
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Meningeal lymphatics stem cognitive decline in craniosynostosis
Cell Stem Cell, 2023Craniosynostosis is a congenital craniofacial disorder where premature fusion of cranial sutures causes elevated intracranial pressure and neurological deficits. In this issue of Cell Stem Cell, Ma et al. demonstrate that replenishing skull progenitor cells alleviates intracranial pressure elevations in craniosynostosis by restoring the meningeal ...
Taylor J, Stevenson +2 more
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The role of meningeal lymphatics in viral meningitis
The Journal of Immunology, 2017Abstract Discovery of the meningeal lymphatic vessels in the brain meninges (coverings of the brain) led to the hypothesis that they carry macromolecules and immune cells from cerebrospinal fluid (CSF) to cervical lymph nodes (cLN). Our new findings suggest that the lymphatic system controls immune responses through guiding antigen ...
Jasmin Herz +3 more
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The meningeal lymphatics: regulators of Aβ immunotherapy?
Trends in Immunology, 2021A new study by Da Mesquita et al. reports on how meningeal lymphatic modulation may influence amyloid-beta immunotherapy and microglial function in mouse models of Alzheimer's disease (AD). This research has broad implications for unraveling the role meningeal lymphatics may play in regulating immunity in the brain during AD pathology and treatment.
Collin Laaker, Zsuzsanna Fabry
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