Results 151 to 160 of about 3,212 (171)
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Meningeal lymphatics, immunity and neuroinflammation
Current Opinion in Neurobiology, 2020In the past five years, the surrounding of the brain, that is the meninges (singular meninx) have evolved from being a physical barrier that protects the brain parenchyma to becoming a central player for both the maintenance of normal brain function and the modulation of neurological disorders.
Antoine Louveau
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Meningeal Lymphatic vasculature in health and disease
Current Opinion in Hematology, 2022Purpose of review The recent (re)discovery of the meningeal lymphatic has brought a new player in brain neurophysiology. This review highlights the state of the current research on the meningeal lymphatic vasculature, from its specific physiology to its increasing implication in normal and pathological brain function.
Nisha, Busch +2 more
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Meningeal lymphatics stem cognitive decline in craniosynostosis
Cell Stem Cell, 2023Craniosynostosis is a congenital craniofacial disorder where premature fusion of cranial sutures causes elevated intracranial pressure and neurological deficits. In this issue of Cell Stem Cell, Ma et al. demonstrate that replenishing skull progenitor cells alleviates intracranial pressure elevations in craniosynostosis by restoring the meningeal ...
Taylor J, Stevenson +2 more
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The role of meningeal lymphatics in viral meningitis
The Journal of Immunology, 2017Abstract Discovery of the meningeal lymphatic vessels in the brain meninges (coverings of the brain) led to the hypothesis that they carry macromolecules and immune cells from cerebrospinal fluid (CSF) to cervical lymph nodes (cLN). Our new findings suggest that the lymphatic system controls immune responses through guiding antigen ...
Jasmin Herz +3 more
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The meningeal lymphatics: regulators of Aβ immunotherapy?
Trends in Immunology, 2021A new study by Da Mesquita et al. reports on how meningeal lymphatic modulation may influence amyloid-beta immunotherapy and microglial function in mouse models of Alzheimer's disease (AD). This research has broad implications for unraveling the role meningeal lymphatics may play in regulating immunity in the brain during AD pathology and treatment.
Collin Laaker, Zsuzsanna Fabry
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Regulation of meningeal lymphatic function by APOE
Alzheimer's & Dementia, 2023AbstractBackgroundThe meningeal layers form a unique interface between the central nervous and peripheral immune systems. The lymphatic vasculature that is present in the meningeal dura and drains cerebrospinal fluid (CSF) becomes dysregulated during aging and in models of neurodegenerative disorders such as Alzheimer’s disease (AD).
NIKOLETA DELIVANOGLOU +10 more
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Meningeal lymphatics mediate drainage of viruses from the CNS
Nature Reviews Neurology, 2022Sarah Lempriere, Lempriere Sarah
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Lymphatic Capillaries in the Meninges of the Human Optic Nerve
Journal of Neuro-Ophthalmology, 1999Although many anatomical studies of the orbit and the optic nerve have been performed, lymphatic capillaries in the dura of the human optic nerve have never been reported. This study was performed to determine whether or not lymphatic capillaries are present in the dura of the human optic nerve.This postmortem study was carried out in seven subjects ...
H E, Killer, H R, Laeng, P, Groscurth
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Meningeal lymphatic network: The middleman of neuroinflammation
Clinical and Experimental Neuroimmunology, 2020AbstractThe central nervous system was long thought to be an immune‐privileged organ, notably because of its lack of conventional lymphatic drainage. Years of scientific observations and the recent (re)discovery of the meningeal lymphatic system has brought new insights into the relationship of the brain with the peripheral immune system.
Sarit Pal, Shilpa Rao, Antoine Louveau
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The role of the meningeal lymphatic in the brain clearing
Saratov Fall Meeting 2018: Computations and Data Analysis: from Nanoscale Tools to Brain Functions, 2019Here in ex vivo (confocal imaging) and in vivo (optical coherent tomography) experiments on adult mice, we clearly demonstrate that the meningeal lymphatic drainage is an important mechanism for the brain clearing that might be also pathway for the brain clearing from metabolites and waste products that requests further detailed studies.
Maria Klimova +9 more
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