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Combinational biosynthesis of isoprene by engineering the MEP pathway in Escherichia coli
Process Biochemistry, 2014Abstract As an important feedstock in petrochemistry, isoprene is used in a wide range of industrial applications. It is produced almost entirely from petrochemical sources; however, these sources are being progressively depleted. A reliable biological process for isoprene production utilizing renewable feedstocks would be an industry-redefining ...
Chun-Li Liu, Lihai Fan, Luo Liu, T. Tan
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Understanding the Mechanisms that Modulate the MEP Pathway in Higher Plants
2012The methyl-d-erythritol 4-phosphate (MEP) pathway is responsible for the biosynthesis of an impressive number of natural compounds of biological and biotechnological importance. In recent years, this pathway has become a clear target to develop new herbicides and antimicrobial drugs. Additionally, the production of a variety of compounds of medical and
Patricia León, Elizabeth Cordoba
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The MEP pathway and the development of inhibitors as potential anti-infective agents
MedChemComm, 2012The non-mevalonate (or MEP) pathway represents an essential biosynthetic route used by plants, algae, and eubacteria to generate isoprenoid precursors. The MEP pathway has also been genetically validated in pathogenic organisms such as P. falciparum and M. tuberculosis.
Ian Hale +4 more
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Investigating structural insights and inhibitor strategies in MEP pathway enzymes
Arzneimittelresistente Infektionen stellen eine erhebliche Bedrohung für die menschliche Gesundheit dar. Studien prognostizieren, dass sie in den nächsten 30 Jahren die führende Todesursache werden könnten. Daher besteht ein dringender Bedarf, neue antimikrobielle Wirkstoffe zu entdecken.openaire +1 more source
This project has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement N° 860816 MepAnti.
Bizzarri, Lorenzo, Bizzarri, Lorenzo
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Bizzarri, Lorenzo, Bizzarri, Lorenzo
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Methylerythritol Phosphate Pathway of Isoprenoid Biosynthesis
Annual Review of Biochemistry, 2013Lishan Zhao, Wei-Chen Chang, Youli Xiao
exaly

