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Beyond rheumatology: Reconsidering methotrexate for Crohn's disease in the biologic era. [PDF]
Seo JY, Yoo JH.
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Hepatotoxicity of Mercaptopurine
JAMA, 1964In a study of 49 leukemic patients, jaundice occurred in 16 of 38 who were treated with mercaptopurine (6-mercaptopurine), but only in one of 11 not receiving the drug. In eight patients jaundice cleared up rapidly on cessation of mercaptopurine therapy, and there was a recurrence of jaundice in two who were rechallenged with the drug.
M, EINHORN, I, DAVIDSOHN
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Pharmacokinetics of Mercaptopurine
Journal of Pharmaceutical Sciences, 1977The anatomical distribution of mercaptopurine was investigated in rats at dose levels of 2.5 and 25 mg/kg iv. The plasma and tissues were analyzed by radioisotopic dilution and spectrofluorometric techniques. The tissue-plasma ratios were: liver-plasma, approximately 4.0; kidney-plasma, approximately 2.4; spleen-plasma, approximately 1.7; muscle-plasma,
L, Tterlikkis +3 more
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