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Pharmacokinetics of Mercaptopurine

Journal of Pharmaceutical Sciences, 1977
The anatomical distribution of mercaptopurine was investigated in rats at dose levels of 2.5 and 25 mg/kg iv. The plasma and tissues were analyzed by radioisotopic dilution and spectrofluorometric techniques. The tissue-plasma ratios were: liver-plasma, approximately 4.0; kidney-plasma, approximately 2.4; spleen-plasma, approximately 1.7; muscle-plasma,
L, Tterlikkis, E, Ortega, R, Solomon, J L, Day   +3 more
openaire   +2 more sources

Hepatotoxicity of Mercaptopurine

JAMA, 1964
In a study of 49 leukemic patients, jaundice occurred in 16 of 38 who were treated with mercaptopurine (6-mercaptopurine), but only in one of 11 not receiving the drug. In eight patients jaundice cleared up rapidly on cessation of mercaptopurine therapy, and there was a recurrence of jaundice in two who were rechallenged with the drug.
M, EINHORN, I, DAVIDSOHN
openaire   +2 more sources

Mercaptopurine

Reactions Weekly, 2016
  +6 more sources

Mercaptopurine

Reactions Weekly, 2017
  +7 more sources

Mercaptopurine

Reactions Weekly, 2010
  +5 more sources

Mercaptopurine

Reactions Weekly, 2018
  +4 more sources

Mercaptopurine

Reactions Weekly, 2021
openaire   +2 more sources

Mercaptopurine

Reactions Weekly, 2015
  +4 more sources