Results 101 to 110 of about 4,546 (178)

DNMT2‐m5C‐ACLY Axis Promotes Lenvatinib Resistance in Hepatocellular Carcinoma Through Histone Acetylation‐Mediated Notch Pathway

Advanced Science, Volume 13, Issue 13, 3 March 2026.
Lenvatinib resistance poses a major challenge in advanced hepatocellular carcinoma (HCC). This study reveals that DNMT2 upregulation is a key driver, which stabilizes ACLY mRNA via m5C modification and activates the Notch signaling pathway. Crucially, combining ACLY inhibitors with lenvatinib overcomes resistance and suppresses tumors, offering a ...
Shiguang Yang, Jie Li, Shengwei Mao, Xuhui Zhao, Douwaner Liu, Jiafeng Chen, Jialu Fu, Yichao Bu, Xiaoling Wu, Shaoqing Liu, Qifeng Yu, Qiongzhu Dong, Zheng Tang, Yuan Fang, Yinghong Shi   +14 more
wiley   +1 more source

ALKBH3 suppresses ischemia/reperfusion‐induced PANoptosis by regulating the ZBED6/STAT1/AIM2 axis through m1A demethylation

Clinical and Translational Medicine, Volume 16, Issue 3, March 2026.
ALKBH3 alleviates myocardial ischemia/reperfusion injury by suppressing PANoptosis. ALKBH3 promotes ZBED6 translation via mRNA m1A demethylation. ZBED6 promotes the interaction between STAT1 and NEDD4L to facilitate STAT1 ubiquitination and subsequent degradation.
Hongtao Diao, Chunlei Wang, Yuting Xiong, Qiaoyue Zhao, Xinyue Zhang, Xiaohui Qi, Yuan Zou, Jiaxuan Li, Linghua Zeng, Wei Si, Feng Zhang, Ping Pang, Ning Wang, Yu Bian, Baofeng Yang   +14 more
wiley   +1 more source

The roles of RNA m6A modification in disease mechanisms of high-risk neuroblastoma [PDF]

Epitranscriptomics involves covalent modifications of RNA bases, with N6-methyladenosine (m6A) being one of the most abundant and functionally characterized. This modification plays a key role in RNA metabolism, cellular differentiation, and DNA damage
Thombare, Ketan
core   +1 more source

ALKBH5‐Driven m6A Demethylation Boosts Inflammation and Autophagy in LPS‐Stimulated Macrophages

Immunity, Inflammation and Disease, Volume 14, Issue 3, March 2026.
ABSTRACT Purpose Acute Respiratory Distress Syndrome (ARDS) remains a critical health threat with limited pharmacological treatments. This study investigates the role of the N6‐methyladenosine (m6A) demethylase AlkB homolog 5 (ALKBH5) in alveolar macrophages and its subsequent impact on inflammation and autophagy during ARDS pathogenesis.
Gui Wang, Ting Zhou, Shujun Zhou
wiley   +1 more source

Statistical Methods for Single-Cell RNA Data [PDF]

Recent advancements in single-cell RNA sequencing (scRNA-seq) have revolutionized transcriptomic research by enabling the study of gene expression at unprecedented resolution, revealing intricate cellular heterogeneity and dynamics.
Wu, Chih-Hsuan
core   +1 more source

RNA framework: An all-in-one toolkit for the analysis of RNA structures and post-transcriptional modifications [PDF]

, 2018
RNA is emerging as a key regulator of a plethora of biological processes. While its study has remained elusive for decades, the recent advent of high-throughput sequencing technologies provided the unique opportunity to develop novel techniques for the ...
Incarnato, D., Morandi, E., Oliviero, S., Simon, L. M.   +3 more
core   +2 more sources

Mettl3‐Mediated m6A Modification Represents a Novel Therapeutic Target for FSGS

Advanced Science, Volume 13, Issue 10, 18 February 2026.
This study explores the roles of Mettl3‐induced N6‐methyladenosine (m6A) modifications in Focal segmental glomerulosclerosis (FSGS). The findings reveal that inhibition of Mettl3 results in podocyte injury by modulating the TJP1CDC42 pathway. Moreover, Administration of N6‐methyladenosine attenuates the FSGS phenotype in WT mice induced by Adriamycin ...
Fubin Zhu, Hongzhi Li, Xiang Li, Chunxiu Du, Ting Wang, Xuling Zhou, Xiaobei Xie, Yunxia Shao, Yingzhi Huang, Yanling Hu, Xinxin Guo, Bin Zhu, Shanshan Yu, Xiaoyan Zhang, Binghai Zhao   +14 more
wiley   +1 more source

HPD is an m6A Methyltransferase that Protects Colorectal Cancer Cells from Ferroptotic Cell Death by m6A Methylating SLC7A11/GPX4

Advanced Science, Volume 13, Issue 9, 13 February 2026.
This study reveals that the tyrosine metabolic enzyme HPD functions as a previously uncharacterized, METTL3‐independent m6A methyltransferase. It promotes colorectal tumor progression by coordinately regulating the SLC7A11/GPX4 axis to suppress ferroptosis.
Jiyan Wang, Xintong Dai, Huanle Liu, Saiwei Hua, Hongkai Chang, Huanran Sun, Mingming Sun, Huifang Zhao, Kemin Ni, Fei Xie, Yaya Qiao, Qingle Gao, Chenxi Yu, Qijun Zhang, Jianshuang Guo, Chunze Zhang, Shuai Zhang, Changliang Shan   +17 more
wiley   +1 more source

M6A reduction relieves FUS-associated ALS granules [PDF]

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease due to gradual motoneurons (MN) degeneration. Among the processes associated to ALS pathogenesis, there is the formation of cytoplasmic inclusions produced by aggregation of ...
Lattante S., Rotili D., Sabatelli M.
core   +1 more source

A comprehensive analysis of differential RNA m6A methylation modifications across the entire transcriptome in PTSD through high-throughput MeRIP sequencing

Brain Research Bulletin
In recent years, the increasing frequency of traumatic events has drawn greater attention to post-traumatic stress disorder (PTSD). However, its underlying biological mechanisms remain poorly understood.
Luodong Yang, Jiaying Lu, Keke Lu, Min Hu, Guiqing Zhang   +4 more
doaj   +1 more source