N6‐methyladenosine reader YTHDF3 regulates melanoma metastasis via its ‘executor' LOXL3
Clinical and Translational Medicine, 2022 Background A number of studies have demonstrated that N6‐methyladenosine (m6A) plays a vital role in the pathological process of various tumours. Recently, it was found that m6A writers or erasers affect the tumourigenesis of melanoma.
Hao‐ze Shi +15 more
doaj +1 more source
Frontiers in Genetics, 2022 As the hub connecting mother and offspring, the placenta’s normal development is vital for fetal growth. Fear stress can cause some structural alterations in the placenta and affect placental development and function. N6-methyladenosine (m6A) is the most
Qiyang Wang +8 more
doaj +1 more source
Altered m6A Modification of Specific Cellular Transcripts Affects Flaviviridae Infection [PDF]
, 2020 The RNA modification N6-methyladenosine (m6A) modulates mRNA fate and thus affects many biological processes. We analyzed m6A across the transcriptome following infection by dengue virus (DENV), Zika virus (ZIKV), West Nile virus (WNV), and hepatitis C ...
Gokhale, N.S. +6 more
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The N⁶-methyladenosine methyltransferase METTL16 enables erythropoiesis through safeguarding genome integrity [PDF]
, 2022 RNA修飾による赤血球造血制御機構を解明 --RNAのメチル化がDNA修復に必要--. 京都大学プレスリリース. 2022-11-10.Mice show METTL in DNA blood repair: RNA methylation shows important role in erythropoiesis. 京都大学プレスリリース. 2022-11-25.During erythroid differentiation, the maintenance of genome integrity
Bassik, Michael C. +16 more
core +2 more sources
Comprehensive Transcriptomic Profiling of m6A Modification in Age-Related Hearing Loss
Biomolecules, 2023 Age-related hearing loss (ARHL), also known as presbycusis, is one of the most common neurodegenerative disorders in elderly individuals and has a prevalence of approximately 70–80% among individuals aged 65 and older.
Menglong Feng +6 more
doaj +1 more source
Altered m6A RNA methylation contributes to hippocampal memory deficits in Huntington's disease mice. [PDF]
, 2022 N6-methyladenosine (m6A) regulates many aspects of RNA metabolism and is involved in learning and memory processes. Yet, the impact of a dysregulation of post-transcriptional m6A editing on synaptic impairments in neurodegenerative disorders remains ...
Alcalá Vida, Rafael +9 more
core +1 more source
Transcriptome-wide analysis of glioma stem cell specific m6A modifications in long-non-coding RNAs
Scientific Reports, 2022 The interest in chemical RNA modifications is rapidly growing in the field of molecular biology. Dynamic and reversible alterations of N6-methyladenosine (m6A) RNA modification are responsible for a platter of structural and functional changes in healthy
Giedrius Steponaitis +7 more
doaj +1 more source
Two zinc finger proteins with functions in m6A writing interact with HAKAI [PDF]
, 2022 The methyltransferase complex (m6A writer), which catalyzes the deposition of N6-methyladenosine (m6A) in mRNAs, is highly conserved across most eukaryotic organisms, but its components and interactions between them are still far from fully understood ...
Archer, Nathan +7 more
core +3 more sources
Transcriptome-wide N6-methyladenosine methylation profile of atherosclerosis in mice
BMC Genomics, 2023 Background Atherosclerosis (AS) is a critical pathological event during the progression of cardiovascular diseases. It exhibits fibrofatty lesions on the arterial wall and lacks effective treatment.
Xinbin Zheng +5 more
doaj +1 more source
Intelligent biology and medicine in 2015: advancing interdisciplinary education, collaboration, and data science [PDF]
, 2016 We summarize the 2015 International Conference on Intelligent Biology and Medicine (ICIBM 2015) and the editorial report of the supplement to BMC Genomics. The supplement includes 20 research articles selected from the manuscripts submitted to ICIBM 2015.
Jianhua Ruan +6 more
core +3 more sources