Results 71 to 80 of about 4,546 (178)

Transcriptome-wide mapping of internal mRNA N 7-methylguanosine in sporulated and unsporulated oocysts of Eimeria tenella reveals stage-specific signatures

Parasites & Vectors
Background Growing evidence indicates that N 7-methylguanosine (m7G) modification plays critical roles in epigenetic regulation. However, no data regarding m7G modification are currently available in Eimeria tenella, a highly virulent species causing ...
Qing-Xin Fan, Zi-Rui Wang, Jin-Long Wang, Yu-Xuan Wang, Ze-Dong Zhang, Lin-Mei Yu, Tao Jia, Xing-Quan Zhu, Qing Liu   +8 more
doaj   +1 more source

BGN/MDK Axis in the Melanoma Tumor Microenvironment Strengthens Tumor Malignancy by Modulating Cancer Cells and Cancer‐Associated Fibroblasts Crosstalk

Advanced Science, EarlyView.
This study reveals that m6A regulators cooperatively upregulate BGN in melanoma, promoting malignancy. Within the tumor microenvironment, CAFs show highest BGN expression. The BGN/MDK axis mediates cancer‐stroma crosstalk, driving normal fibroblast (NF) activation and enhancing the pro‐tumor effect of CAFs, highlighting a promising therapeutic target ...
Hao‐ze Shi, Ming‐yang Wu, Jin‐quan Liu, Cuicui Tian, Li Ma, Xue‐mei Zhou, Ze‐Hao Sun, Zhi‐yong Xu, Run‐dong Zhang, Shan‐yuan Ye, Li‐ming Huang, Yan Wang, Jing‐shu Xiong, Wen‐bo Bu, Xian‐feng Cheng, Jian‐fang Sun, Hao Chen   +16 more
wiley   +1 more source

m6A-mRNA Methylation Regulates Gene Expression and Programmable m6A Modification of Cellular RNAs With CRISPR-Cas13b in Renal Cell Carcinoma

Frontiers in Genetics, 2022
Background: N6-methyladenosine (m6A) is the most extensive messenger RNA modification. Despite recent advances in the biological roles of m6A, its role in the development and progression of renal cell carcinoma (RCC) remains unclear.Methods: In this ...
Ying Gan, Ying Gan, Aolin Li, Aolin Li, Jun Liu, Jun Liu, Xiaofei Wang, Xiaofei Wang, Zhenan Zhang, Zhenan Zhang, Qinhan Li, Qinhan Li, Xiongjun Ye, Xiongjun Ye, Lin Yao, Lin Yao, Qian Zhang, Qian Zhang   +17 more
doaj   +1 more source

Global analysis of N6-methyladenosine functions and its disease association using deep learning and network-based methods [PDF]

, 2019
N6-methyladenosine (m6A) is the most abundant methylation, existing in >25% of human mRNAs. Exciting recent discoveries indicate the close involvement of m6A in regulating many different aspects of mRNA metabolism and diseases like cancer.
Chen, Yidong, Fan, Xiao-Nan, Gao, Shou-Jiang, Huang, Yufei, Meng, Jia, Zhang, Shao-Wu, Zhang, Song-Yao   +6 more
core   +2 more sources

Tumor Extracellular Vesicles lncOSLMT Drives Lung Inflammatory Premetastatic Niche Formation in Osteosarcoma via m6A‐Dependent hnRNPA2B1/COX‐2 Axis

Advanced Science, EarlyView.
Tumor‐derived extracellular vesicles program inflammatory lung premetastatic niches through selective delivery of long noncoding RNAs. This work reveals EVs‐associated lncOSLMT as a key driver of lung fibroblast activation via m6A‐dependent PTGS2 stabilization.
Hongbo Li, Zehao Guo, Yutong Zou, Jiongfeng Zhang, Jixiang Shi, Xihong Fu, Jian Tu, Hao Yao, Xuanxuan Lu, Lili Wen, Xianbiao Xie   +10 more
wiley   +1 more source

The N6-methyladenosine Epitranscriptomic Landscape of Lung Adenocarcinoma. [PDF]

Comprehensive N6-methyladenosine (m6A) epitranscriptomic profiling of primary tumors remains largely uncharted. Here, we profiled the m6A epitranscriptome of 10 nonneoplastic lung tissues and 51 lung adenocarcinoma (LUAD) tumors, integrating the ...
Ahmed, Musaddeque, Boutros, Paul, Cai, Zongwei, Chen, Moliang, Chen, Sujun, Chen, Wei, Cheng, Chao, Guan, Jiansheng, He, Housheng, Ke, Zunfu, Khan, Aafaque, Liu, Ni, Liu, Yanming, Luo, Weishan, Moran, Michael, Pham, Nhu-An, Sakashita, Shingo, Slobodyanyuk, Mykhaylo, Su, Peiran, Tsao, Ming, Wang, Lina, Wang, Shiyan, Xie, Zhongpeng, Xu, Xin, Yang, Weixiong, Yu, Jun, Zeng, Yong, Zhang, Min, Zhang, Wen, Zhang, Xinyue, Zhou, Lei, Zhu, Helen, Zhu, Lin   +32 more
core   +1 more source

Prediction of RNA Methylation Status From Gene Expression Data Using Classification and Regression Methods [PDF]

, 2020
RNA N6-methyladenosine (m6A) has emerged as an important epigenetic modification for its role in regulating the stability, structure, processing, and translation of RNA. Instability of m6A homeostasis may result in flaws in stem cell regulation, decrease
Chen, Kunqi, Meng, Jia, Su, Jionglong, Tang, Yujiao, Wei, Zhen, Wu, Xiangyu, Xue, Hao   +6 more
core   +1 more source

Targeting WTAP/ROR1/WNT5A‐Mediated Crosstalk Between Glioma Stem Cells and Macrophages to Normalize Tumor Vasculature and Enhance Chemotherapy

Advanced Science, EarlyView.
In hypoxic microenvironment, WNT5A is predominantly secreted by tumor‐associated macrophages. Hypoxia‐induced WTAP mediates ROR1 stability by m6A modifications in a HuR‐dependent manner in Glioma stem cells (GSCs). WNT5A activates the WNT pathway via ROR1 binding on GSCs, driving glioma‐derived endothelial cells (GDECs) differentiation.
Xiaoyong Chen, Bo Pang, Yun Liu, Jiangwei Wang, Lanhui Zheng, Yuzhou Chang, Yingxuan Sun, Haoyuan Sun, Huiyuan Chen, Jiawei Cai, Zanyi Wu, Qing Chang, Yongzhi Wang, Dezhi Kang, Tao Jiang, Ruichao Chai   +15 more
wiley   +1 more source

Global m6A methylation and gene expression patterns in human microglial HMC3 cells infected with HIV-1

Heliyon, 2023
N6-methyladenosine (m6A) methylation of human immunodeficiency virus type 1 (HIV-1) RNA regulates viral replication, and the m6A of host RNA is affected by HIV-1 infection, but its global pattern and function are still unclear.
Qian Peng, Jialu Qiao, Weiling Li, Qiang You, Song Hu, Yuchen Liu, Wei Liu, Kanghong Hu, Binlian Sun   +8 more
doaj   +1 more source

Additional file 1 of MoAIMS: efficient software for detection of enriched regions of MeRIP-Seq

, 2020
Additional file 1 Supplementary materials for "MoAIMS: efficient software for detection of enriched regions of MeRIP-Seq".
Yiqian Zhang, Hamada, Michiaki
openaire   +1 more source