Merkel cell polyomavirus and associated Merkel cell carcinoma
Tumour Virus Research, 2022 Merkel cell polyomavirus (MCPyV) is a ubiquitous skin infection that can cause Merkel cell carcinoma (MCC), a highly lethal form of skin cancer with a nearly 50% mortality rate.
June F. Yang, Jianxin You
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Dermal appendage-dependent patterning of zebrafish atoh1a+ Merkel cells
eLife, 2023 Touch system function requires precise interactions between specialized skin cells and somatosensory axons, as exemplified by the vertebrate mechanosensory Merkel cell-neurite complex.
Tanya L Brown +9 more
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Merkel cell carcinoma in an immunosuppressed patient [PDF]
Anais Brasileiros de Dermatologia, 2017 Merkel cell carcinoma is an uncommon neuroendocrine carcinoma with a rising incidence and an aggressive behavior. It predominantly occurs in older patients, with onset occurring at a mean age of 75-80 years.
Heliana Freitas de Oliveira Góes +5 more
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Polycomb-Mediated Repression and Sonic Hedgehog Signaling Interact to Regulate Merkel Cell Specification during Skin Development. [PDF]
PLoS Genetics, 2016 An increasing amount of evidence indicates that developmental programs are tightly regulated by the complex interplay between signaling pathways, as well as transcriptional and epigenetic processes.
Carolina N Perdigoto +10 more
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Merkel Cell Polyomavirus Small T Antigen Induces Cancer and Embryonic Merkel Cell Proliferation in a Transgenic Mouse Model. [PDF]
PLoS ONE, 2015 Merkel cell polyomavirus (MCV) causes the majority of human Merkel cell carcinomas (MCC) and encodes a small T (sT) antigen that transforms immortalized rodent fibroblasts in vitro. To develop a mouse model for MCV sT-induced carcinogenesis, we generated
Masahiro Shuda +10 more
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Merkel cell carcinoma: epidemiology, clinical features, diagnosis and treatment of a rare disease
Anais Brasileiros de Dermatologia, 2023 Merkel cell carcinoma is a rare skin cancer with neuroendocrine differentiation. The risk factors include sun exposure, advanced age, immunosuppression (such as transplant recipients, patients with lymphoproliferative neoplasms, or patients with HIV ...
Stella Meireles Siqueira +4 more
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Multiple gastrointestinal metastases of Merkel cell carcinoma
Medicina, 2016 Merkel cell carcinoma is an aggressive skin malignancy. Primary Merkel cell carcinomas are treated by wide radical excision with or without adjuvant radiotherapy, while benefits of adjuvant chemotherapy remain doubtful.
Eligijus Poškus +5 more
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Dual innervation of neonatal Merkel cells in mouse touch domes. [PDF]
PLoS ONE, 2014 Merkel cell-neurite complexes are specialized mechanosensory end organs that mediate discriminative touch sensation. It is well established that type I slowly adapting (SAI) mechanoreceptors, which express neural filament heavy chain (NFH), innervate ...
Jingwen Niu, Anna Vysochan, Wenqin Luo
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Treatment and Outcome of Merkel Cell Carcinoma in A Single Center
Zhongliu Fangzhi Yanjiu, 2023 Objective To investigate the clinical features, treatment, and outcome characteristics of patients with Merkel cell carcinoma. Methods The clinical manifestations, laboratory tests, diagnosis and treatment, and follow-up data of six patients with Merkel ...
REN Mengwei, XUE Xuemin, LIU Peng
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Primary Merkel cell carcinoma of the salivary gland: a clinicopathologic study of four cases with a review of literature [PDF]
Journal of Pathology and Translational MedicineBackground Primary Merkel cell carcinoma of the salivary gland is currently not listed in the World Health Organization classification. However, cases of Merkel cell type neuroendocrine carcinomas of the salivary gland with perinuclear cytokeratin 20 ...
Gyuheon Choi +6 more
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