Merkel cell polyomavirus and associated Merkel cell carcinoma
Tumour Virus Research, 2022 Merkel cell polyomavirus (MCPyV) is a ubiquitous skin infection that can cause Merkel cell carcinoma (MCC), a highly lethal form of skin cancer with a nearly 50% mortality rate.
June F. Yang, Jianxin You
doaj +3 more sources
Tumor virus–induced lineage survival circuit drives Merkel cell carcinogenesis [PDF]
The Journal of Clinical InvestigationApproximately 80% of Merkel cell carcinoma (MCC) cases are caused by Merkel cell polyomavirus (MCV), driven by its T antigen oncogene. Why MCV drives MCC, a skin cancer that displays the neuroendocrine Merkel cell phenotype, remains unclear.
Masahiro Shuda
doaj +2 more sources
From Merkel Cell Polyomavirus Infection to Merkel Cell Carcinoma Oncogenesis
Frontiers in Microbiology, 2021 Merkel cell polyomavirus (MCPyV) infection causes near-ubiquitous, asymptomatic infection in the skin, but occasionally leads to an aggressive skin cancer called Merkel cell carcinoma (MCC).
Nathan A. Krump, Jianxin You
doaj +3 more sources
Dermal appendage-dependent patterning of zebrafish atoh1a+ Merkel cells
eLife, 2023 Touch system function requires precise interactions between specialized skin cells and somatosensory axons, as exemplified by the vertebrate mechanosensory Merkel cell-neurite complex.
Tanya L Brown +9 more
doaj +1 more source
Merkel cell carcinoma in an immunosuppressed patient [PDF]
Anais Brasileiros de Dermatologia, 2017 Merkel cell carcinoma is an uncommon neuroendocrine carcinoma with a rising incidence and an aggressive behavior. It predominantly occurs in older patients, with onset occurring at a mean age of 75-80 years.
Heliana Freitas de Oliveira Góes +5 more
doaj +1 more source
Contemporary Literature Review of Clinical Characteristics and Management of Merkel Cell Carcinoma [PDF]
Liaquat National Journal of Cancer Care, 2022 Merkel cell carcinoma is a rare aggressive, non-melanomatous cutaneous malignancy with rising incidence. It has two distinct etiologies Merkel cell polyomavirus associated and non-associated, usually presents as painless, indurated, solitary violaceous
Laraib Khan +4 more
doaj +1 more source
Polycomb-Mediated Repression and Sonic Hedgehog Signaling Interact to Regulate Merkel Cell Specification during Skin Development. [PDF]
PLoS Genetics, 2016 An increasing amount of evidence indicates that developmental programs are tightly regulated by the complex interplay between signaling pathways, as well as transcriptional and epigenetic processes.
Carolina N Perdigoto +10 more
doaj +1 more source
Merkel Cell Polyomavirus Small T Antigen Induces Cancer and Embryonic Merkel Cell Proliferation in a Transgenic Mouse Model. [PDF]
PLoS ONE, 2015 Merkel cell polyomavirus (MCV) causes the majority of human Merkel cell carcinomas (MCC) and encodes a small T (sT) antigen that transforms immortalized rodent fibroblasts in vitro. To develop a mouse model for MCV sT-induced carcinogenesis, we generated
Masahiro Shuda +10 more
doaj +1 more source
Multiple gastrointestinal metastases of Merkel cell carcinoma
Medicina, 2016 Merkel cell carcinoma is an aggressive skin malignancy. Primary Merkel cell carcinomas are treated by wide radical excision with or without adjuvant radiotherapy, while benefits of adjuvant chemotherapy remain doubtful.
Eligijus Poškus +5 more
doaj +1 more source
Merkel cell carcinoma: epidemiology, clinical features, diagnosis and treatment of a rare disease
Anais Brasileiros de Dermatologia, 2023 Merkel cell carcinoma is a rare skin cancer with neuroendocrine differentiation. The risk factors include sun exposure, advanced age, immunosuppression (such as transplant recipients, patients with lymphoproliferative neoplasms, or patients with HIV ...
Stella Meireles Siqueira +4 more
doaj +1 more source