Results 31 to 40 of about 13,982 (210)

Avelumab in patients with previously treated metastatic Merkel cell carcinoma: long-term data and biomarker analyses from the single-arm phase 2 JAVELIN Merkel 200 trial

Journal for ImmunoTherapy of Cancer, 2020
Background Merkel cell carcinoma (MCC) is a rare, aggressive skin cancer associated with a high risk of metastasis. In 2017, avelumab (anti–programmed death-ligand 1 (PD-L1)) became the first approved treatment for patients with metastatic MCC (mMCC ...
S. D’Angelo, S. Bhatia, A. Brohl, O. Hamid, J. Mehnert, P. Terheyden, K. Shih, I. Brownell, C. Lebbé, K. Lewis, G. Linette, M. Milella, Sara Georges, Parantu K. Shah, B. Ellers-Lenz, M. Bajars, G. Güzel, P. Nghiem   +17 more
semanticscholar   +1 more source

Avelumab in patients with chemotherapy-refractory metastatic Merkel cell carcinoma: a multicentre, single-group, open-label, phase 2 trial

The Lancet Oncology, 2016
Summary Background Merkel cell carcinoma is a rare, aggressive skin cancer with poor prognosis in patients with advanced disease. Current standard care uses various cytotoxic chemotherapy regimens, but responses are seldom durable.
H. Kaufman, J. Russell, O. Hamid, S. Bhatia, P. Terheyden, S. D’Angelo, K. Shih, C. Lebbé, G. Linette, M. Milella, I. Brownell, K. Lewis, J. Lorch, K. Chin, L. Mahnke, A. von Heydebreck, J. Cuillerot, P. Nghiem   +17 more
semanticscholar   +1 more source

Merkel cell carcinoma

Cellular and Molecular Life Sciences, 2008
Merkel cell carcinoma (MCC) is a highly aggressive neuroendocrine carcinoma of the skin. More than one-third of MCC patients will die from this cancer, making it twice as lethal as malignant melanoma. Despite the fact that MCC is still a very rare tumor, its incidence is rapidly increasing; the American Cancer Society estimates for 2008 almost 1,500 ...
J C, Becker, D, Schrama, R, Houben
  +7 more sources

Merkel Cell Carcinoma of Unknown Primary: Immunohistochemical and Molecular Analyses Reveal Distinct UV-Signature/MCPyV-Negative and High Immunogenicity/MCPyV-Positive Profiles

Cancers, 2021
Simple Summary Merkel cell carcinomas (MCCs) of unknown primary are defined as deep-seated tumors without an associated cutaneous tumor. Although the distinction has important clinical implications, it remains unclear whether these tumors represent ...
P. Donizy, J. Wróblewska, D. Dias-Santagata, K. Woźnica, P. Biecek, M. Mochel, Cheng-Lin Wu, J. Kopczyński, Małgorzata Pieniążek, J. Ryš, A. Marszałek, M. Hoang   +11 more
semanticscholar   +1 more source

Extensive central nervous system involvement in Merkel cell carcinoma: a case report and review of the literature

Journal of Medical Case Reports, 2011
Introduction Merkel cell carcinoma is a rare malignant cutaneous neoplasm that is locally invasive and frequently metastasizes to lymph nodes, liver, lungs, bone and brain.
Söderström Kristina, Abul-Kasim Kasim, Hallsten Lennart   +2 more
doaj   +1 more source

Kidney metastasis in a case of Merkel cell carcinoma

Urology Case Reports, 2021
Merkel cell carcinoma is a rare neuroendocrine skin tumor with a poor prognosis. Metastasis is frequent and is seen in the first few years after diagnosis.
Abdessamade Motaouakil, Ibrahim Boukhannous, Mehdi Chennoufi, Anouar El Moudane, Mohamed Mokhtari, Ali Barki   +5 more
doaj   +1 more source

Merkel cell carcinoma metastasis and dermatofibrosarcoma protuberans presenting as a collision tumour: a case report and review of the literature

Journal of Medical Case Reports, 2009
Introduction Merkel cell carcinoma and dermatofibrosarcoma protuberans are two very rare neoplasms. The simultaneous occurrence of two different tumour entities at the same anatomical site, collision tumours, is a rare phenomenon.
Tilkorn Daniel-Johannes, Lehnhardt Marcus, Hauser Jörg, Daigler Adrien, Homann Heinz, Steinau Hans, Kuhnen Cornelius   +6 more
doaj   +1 more source

Merkel cell carcinoma with axillary metastasis; a case report of a rare disease

Journal of Oncological Sciences, 2018
Merkel cell carcinoma is a rare primer neuroendocrine carcinoma of the skin. It is an extremely aggressive tumor. This rare carcinoma is seen with high local and regional recurrence ratios and distant metastasis.
Serdar Culcu, Aydan Eroglu, Aylin Heper
doaj   +1 more source

YouTube as a source of information on Merkel cell carcinoma

Turkderm Turkish Archives of Dermatology and Venereology, 2023
Background and Design: To evaluate the content and reliability of Merkel cell carcinoma videos on YouTube, the most frequently used videosharing platform to access information.
Abdullah Evren Yetişir
doaj   +1 more source

Survival outcomes and epidemiology of Merkel cell carcinoma of the lower limb and hip: A Surveillance, Epidemiology, and End Results analysis 2000-2018Capsule Summary

JAAD International, 2022
Background: Merkel cell carcinoma of lower limb and hip skin is a rare skin tumor that has a high recurrence rate. Objective: To assess epidemiology and survival outcomes of the lower limb and hip Merkel cell carcinoma, which are less addressed in the ...
Matteo Scampa, MS, Rastine Merat, MD, PhD, Evangelia Tzika, MD, Daniel F. Kalbermatten, MD, PhD, Carlo M. Oranges, MD, PhD   +4 more
doaj   +1 more source