Results 51 to 60 of about 13,982 (210)

Vulvar neuroendocrine carcinoma that is independent of merkel cell polyomavirus and human papillomavirus suggests endometrial cancer recurrence: a case report

BMC Endocrine Disorders, 2022
Background Vulvar neuroendocrine carcinomas with small cell morphology need an appropriate differential diagnosis with respect to primary Merkel cell carcinomas, primary small cell neuroendocrine carcinomas, and secondary/metastatic carcinomas.
Tomoko Hirakawa, Mitsutake Yano, Haruto Nishida, Shimpei Sato, Kaei Nasu   +4 more
doaj   +1 more source

CCL3 and IL‐7 Synergistically Enhance CAR‐T Efficacy in Solid Tumors

Advanced Science, EarlyView.
Synergistic delivery of CCL3 and IL‐7 by CAR‐T cells overcomes the immunosuppressive tumor microenvironment by enhancing cell infiltration, survival, and local immune reprogramming. This also establishes positive feedback that amplifies anti‐tumor activity and memory responses in both CAR‐T and endogenous T cells, presenting a robust therapeutic ...
Huanpeng Chen, Xiaoyun Luo, Huixin Gao, Yujing Ke, Yu Zhan, Xiaoting Xu, Xiaoxiao Xiong, Fengjiao Wei, Si Yang, Zhonghua Liu, Bolan Yu, Zhaofeng Huang, Yingjie Bian   +12 more
wiley   +1 more source

Merkel-Cell Carcinoma

New England Journal of Medicine
Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine skin cancer that is highly radiosensitive and immunogenic. Immunotherapy is the primary treatment of advanced disease, and immune checkpoint inhibitors show promise as neoadjuvant or adjuvant therapy in patients with high-risk resectable MCC.
Zunaid Ahmed, Willem Visser
  +8 more sources

Concomitant chronic lymphocytic leukemia and Merkel cell carcinoma

Dermatologica Sinica, 2015
We present the case of a 69-year-old Caucasian man with a 5-year history of untreated chronic lymphocytic leukemia who presented with Merkel cell carcinoma on the right gluteal region.
Darko Antic, Jelena Jelicic, Vojin Vukovic, Gordana Pupic, Zorka Milovanovic, Biljana Mihaljevic   +5 more
doaj   +1 more source

The 9th Edition of the UICC TNM Classification of Malignant Tumours: Updates and Rationale for Change

International Journal of Cancer, EarlyView.
ABSTRACT The standard for assessing and recording the extent of the tumour, a necessity for most malignancies, is the Tumour Node Metastases (TNM) classification. The Union for International Cancer Control (UICC) TNM committee has defined this since the early 1950s.
James D. Brierley, Liesbet J. Van Eycken, Meredith E. Giuliani, Brian A. Rous, Shao Hui Huang, Hisao Asamura, Mary K. Gospodarowicz, Anne W. Lee, Brian O'Sullivan   +8 more
wiley   +1 more source

Durable Tumor Regression and Overall Survival in Patients With Advanced Merkel Cell Carcinoma Receiving Pembrolizumab as First-Line Therapy.

Journal of Clinical Oncology, 2018
PURPOSE Merkel cell carcinoma (MCC) is an aggressive skin cancer often caused by the Merkel cell polyomavirus. Clinical trials of programmed cell death-1 pathway inhibitors for advanced MCC (aMCC) demonstrate increased progression-free survival (PFS ...
P. Nghiem, S. Bhatia, E. Lipson, W. Sharfman, R. Kudchadkar, A. Brohl, P. Friedlander, A. Daud, H. Kluger, S. Reddy, B. Boulmay, A. Riker, M. Burgess, B. Hanks, T. Olencki, K. Margolin, Lisa M Lundgren, A. Soni, N. Ramchurren, C. Church, Song Y Park, M. Shinohara, Bob A. Salim, J. Taube, S. Bird, N. Ibrahim, S. Fling, B. Homet Moreno, E. Sharon, M. Cheever, S. Topalian   +30 more
semanticscholar   +1 more source

Efficacy and safety of avelumab treatment in patients with metastatic Merkel cell carcinoma: experience from a global expanded access program

Journal for ImmunoTherapy of Cancer, 2020
Background Avelumab, a human anti–programmed death-ligand 1 immunoglobulin G1 monoclonal antibody, showed favorable efficacy and safety in patients with metastatic Merkel cell carcinoma (mMCC) in the phase II JAVELIN Merkel 200 trial, leading to approval
J. Walker, C. Lebbé, G. Grignani, P. Nathan, L. Dirix, E. Fenig, P. Ascierto, S. Sandhu, R. Munhoz, E. Benincasa, Sarah Flaskett, J. Reed, A. Engelsberg, S. Hariharan, V. Kasturi   +14 more
semanticscholar   +1 more source

MERKEL CELL CARCINOMA – PRO AND CONS ASPECTS FOR SENTINEL LYMPH NODE BIOPSY [PDF]

Romanian Medical Journal, 2019
Merkel cell carcinoma represents an aggressive histopathological subtype of skin cancer with a high propensity to spread via lymphatic route. Once the benefits of the sentinel lymph node detection have been proven in malignant melanoma, the effectiveness
Nicolae Bacalbasa, Irina Balescu, Mihai Dimitriu, Mihaela Vilcu, Iulian Brezean   +4 more
doaj   +1 more source

LSD1 inhibition induces differentiation and cell death in Merkel cell carcinoma

EMBO Molecular Medicine, 2020
Merkel cell carcinoma (MCC) is a highly aggressive, neuroendocrine skin cancer that lacks actionable mutations, which could be utilized for targeted therapies.
L. Leiendecker, P. Jung, Izabela Krecioch, Tobias Neumann, A. Schleiffer, K. Mechtler, T. Wiesner, A. Obenauf   +7 more
semanticscholar   +1 more source

Merkel cell carcinoma and sarcoidosis — an association like no other

Oncology in Clinical Practice
The association between Merkel cell carcinoma of unknown origin and sarcoidosis is rarely documented, pos­ing a significant challenge in distinguishing between these two conditions with drastically different prognoses.
Maaroufi Abdelkhaleq, Benameur Yasser, Essaoudi Amine Mohamed, Fatihi Jamal   +3 more
doaj   +1 more source