Results 61 to 70 of about 13,982 (210)
The Journal of Dermatology, EarlyView.ABSTRACT Immune checkpoint inhibitor (ICI)‐driven alterations in the immune system can induce immune‐related adverse events (irAEs). Cutaneous irAEs are notable for being the most common and for their early onset; however, the risk factors underlying their development and severity remain unclear. In this study, we retrospectively analyzed 1224 Japanese
Tomoya Watanabe +4 more
wiley +1 more source
American Journal of Clinical Oncology, 2013 Merkel cell carcinoma (MCC) is a rare, clinically aggressive cutaneous neuroendocrine neoplasm with a high mortality rate. Though the etiology is not precisely known, Merkel cell polyomavirus DNA has been found recently in a large percentage of MCC tumors.
Emma, Ramahi +3 more
openaire +2 more sources
Selective reactivation of STING signaling to target Merkel cell carcinoma
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance The immune-dampened status of Merkel cell carcinoma (MCC) tumors presents a major obstacle to developing effective immunotherapies. We propose that STING silencing may cause the immunologically “cold” MCC tumor microenvironments by blocking ...
Wei Liu +5 more
semanticscholar +1 more source
ANZ Journal of Surgery, EarlyView.ABSTRACT Background Merkel cell carcinoma (MCC) is a rare, aggressive cutaneous neuroendocrine malignancy with a high risk of nodal metastasis. Sentinel lymph node biopsy (SLNB) is used to stage clinically node‐negative disease and to guide adjuvant therapy decisions.
Julie Ahn +2 more
wiley +1 more source
JAMA Oncology, 2018 Importance Merkel cell carcinoma (MCC) is an aggressive skin cancer that is associated with poor survival outcomes in patients with distant metastatic disease.
S. D’Angelo +12 more
semanticscholar +1 more source
Merkel Cell Carcinoma: Interdisciplinary Management of a Rare Disease
Journal of Skin Cancer, 2013 Background. The goal of this paper is to review contemporary multidisciplinary treatment with reference to Merkel cell carcinoma. Management of this rare but highly aggressive skin cancer is a complex undertaking that necessitates an understanding of its
Sven Schneider +2 more
doaj +1 more source
Oncogenic Role of an Epigenetic Reader of m6A RNA Modification: YTHDF1 in Merkel Cell Carcinoma
Cancers, 2020 Merkel cell carcinoma is a deadly skin cancer, which in the majority of cases is caused by the Merkel cell polyomavirus (MCPyV). The viral small T antigen is regarded as the dominant oncoprotein expressed in the tumor cells.
Elias Orouji +4 more
semanticscholar +1 more source
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Immune checkpoint inhibitors (ICI) have revolutionized cancer therapy, offering improvements in survival across various malignancies. However, their toxicities pose a major challenge for cardio‐oncology units. Despite their growing importance, data on effectiveness of such specialized units in mitigating ICI‐associated ...
Elias Haj‐Yehia +6 more
wiley +1 more source
Acta Dermato-VenereologicaMerkel cell carcinoma is a rare, aggressive skin cancer in which Merkel cell polyoma virus (MCPyV) is frequently pathogenically involved. After failure of anti-programmed cell death protein 1/programmed cell death ligand 1 immunotherapy, therapeutic ...
Ferdinand Toberer +8 more
doaj +1 more source
Merkel cell carcinoma with seborrheic keratosis: A unique association
Indian Journal of Pathology and Microbiology, 2018 Merkel cell carcinoma (MCC) is a rare, clinically aggressive neuroendocrine carcinoma of the skin; MCC is 40 times less common as compared to melanoma. The most frequently reported sites have been the head and neck, extremities, and trunk.
Murthy S Anand +3 more
doaj +1 more source