Results 21 to 30 of about 13,982 (210)

Merkel Cell Carcinoma [PDF]

Journal of the National Comprehensive Cancer Network, 2009
(Staging for Merkel Cell of the eyelid [C44.1] is not included in this chapter – see Chap. 48, “Carcinoma of the Eyelid” in the AJCC Cancer Staging Manual)
Stanley J, Miller, Murad, Alam, James, Andersen, Daniel, Berg, Christopher K, Bichakjian, Glen, Bowen, Richard T, Cheney, L Frank, Glass, Roy C, Grekin, Dennis E, Hallahan, Anne, Kessinger, Nancy Y, Lee, Nanette, Liegeois, Daniel D, Lydiatt, Jeff, Michalski, William H, Morrison, Kishwer S, Nehal, Kelly C, Nelson, Paul, Nghiem, Thomas, Olencki, Allan R, Oseroff, Clifford S, Perlis, E William, Rosenberg, Ashok R, Shaha, Marshall M, Urist, Linda C, Wang   +25 more
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Diagnosis and treatment of Merkel cell carcinoma: European consensus-based interdisciplinary guideline - Update 2022.

European Journal of Cancer, 2022
Merkel cell carcinoma (MCC) is a rare skin cancer, accounting for less than 1% of all cutaneous malignancies. It is found predominantly in white populations and risk factors include advanced age, ultraviolet exposure, male sex, immunosuppression, such as
Marie-Léa Gauci, C. Aristei, J. Becker, A. Blom, V. Bataille, B. Dréno, V. del Marmol, A. Forsea, M. Fargnoli, J. Grob, F. Gomes, A. Hauschild, C. Hoeller, C. Harwood, N. Kelleners-Smeets, R. Kaufmann, A. Lallas, J. Malvehy, D. Moreno-Ramírez, K. Peris, G. Pellacani, P. Saiag, A. Stratigos, R. Vieira, I. Zalaudek, A. V. Van Akkooi, P. Lorigan, C. Garbe, C. Lebbé   +28 more
semanticscholar   +1 more source

Merkel Cell Polyomavirus: Infection, Genome, Transcripts and Its Role in Development of Merkel Cell Carcinoma

Cancers, 2023
Simple Summary By studying the cancer-inducing ability of polyomaviruses, several milestones in cancer research crucially contributing to our current understanding of, e.g., the tumor suppressor proteins p53 and RB1 have been achieved. However, only with
R. Houben, Büke Celikdemir, T. Kervarrec, D. Schrama   +3 more
semanticscholar   +1 more source

S2k Guideline – Merkel cell carcinoma (MCC, neuroendocrine carcinoma of the skin) – Update 2022

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 2023
Merkel cell carcinoma (MCC, ICD‐O M8247/3) is a rare, malignant, primary skin tumor with epithelial and neuroendocrine differentiation. The tumor cells share many morphologic, immunohistochemical, and ultrastructural features with cutaneous Merkel cells.
Jürgen C. Becker, A. Beer, V. DeTemple, T. Eigentler, M. Flaig, T. Gambichler, S. Grabbe, U. Höller, B. Klumpp, S. Lang, C. Pföhler, C. Posch, V. Prasad, P. Schlattmann, S. Schneider-Burrus, J. Ter‐Nedden, P. Terheyden, K. Thoms, D. Vordermark, S. Ugurel   +19 more
semanticscholar   +1 more source

From Merkel Cell Polyomavirus Infection to Merkel Cell Carcinoma Oncogenesis

Frontiers in Microbiology, 2021
Merkel cell polyomavirus (MCPyV) infection causes near-ubiquitous, asymptomatic infection in the skin, but occasionally leads to an aggressive skin cancer called Merkel cell carcinoma (MCC).
Nathan A. Krump, Jianxin You
semanticscholar   +1 more source

Epigenetic Dysregulations in Merkel Cell Polyomavirus-Driven Merkel Cell Carcinoma

International Journal of Molecular Sciences, 2021
Merkel cell polyomavirus (MCPyV) is a small DNA virus with oncogenic potential. MCPyV is the causative agent of Merkel Cell Carcinoma (MCC), a rare but aggressive tumor of the skin.
J. Rotondo, C. Mazziotta, C. Lanzillotti, M. Tognon, F. Martini   +4 more
semanticscholar   +1 more source

Merkel Cell Carcinoma: New Trends

Cancers, 2021
Simple Summary In this review, we discuss a rare skin cancer that occurs mostly in elderly people called “Merkel cell carcinoma” (MCC). The incidence is increasing due to ageing of the population, increased sun exposure, and the use of medication that ...
E. Zwijnenburg, S. Lubeek, J. Werner, A. Amir, W. Weijs, R. Takes, S. Pegge, C. V. van Herpen, G. Adema, J. Kaanders   +9 more
semanticscholar   +1 more source

Neoadjuvant Therapy for Non-melanoma Skin Cancer: Updated Therapeutic Approaches for Basal, Squamous, and Merkel Cell Carcinoma

Current Treatment Options in Oncology, 2021
Recently introduced systemic therapies for locally advanced and metastatic non-melanoma skin cancers (NMSCs) are paving the way for neoadjuvant approach.
E. Zelin, I. Zalaudek, M. Agozzino, C. Dianzani, A. Dri, N. di Meo, R. Giuffrida, G. Marangi, N. Neagu, P. Persichetti, L. Toffoli, C. Conforti   +11 more
semanticscholar   +1 more source

Merkel cell polyomavirus-negative -Merkel cell carcinoma originating from in situ squamous cell carcinoma: a keratinocytic tumor with neuroendocrine differentiation.

Journal of Investigative Dermatology, 2021
While virus-negative Merkel cell carcinoma (MCC) is characterized by high frequency of UV-induced mutations, expression of two viral oncoproteins is regarded as key mechanism driving Merkel cell polyomavirus (MCPyV)-positive MCC. The cells in which these
T. Kervarrec, S. Appenzeller, M. Samimi, B. Sarma, Eva-Maria Sarosi, P. Berthon, Y. Le Corre, Ewa Hainaut-Wierzbicka, A. Blom, Nathalie Benethon, G. Bens, Charline Nardin, F. Aubin, M. Dinulescu, M. Jullie, Ágnes Pekár-Lukacs, E. Calonje, Soumanth Thanguturi, A. Tallet, M. Wobser, A. Touzé, S. Guyétant, R. Houben, D. Schrama   +23 more
semanticscholar   +1 more source

Neoadjuvant Nivolumab for Patients With Resectable Merkel Cell Carcinoma in the CheckMate 358 Trial.

Journal of Clinical Oncology, 2020
PURPOSE Merkel cell carcinoma (MCC) is a rare, aggressive skin cancer commonly driven by the Merkel cell polyomavirus (MCPyV). The programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1) immunosuppressive pathway is often upregulated in MCC, and ...
S. Topalian, S. Bhatia, A. Amin, R. Kudchadkar, W. Sharfman, C. Lebbé, J. Delord, L. Dunn, M. Shinohara, R. Kulikauskas, C. Chung, U. Martens, R. Ferris, Julie E. Stein, Elizabeth L. Engle, L. Devriese, C. Lao, Junchen Gu, Bin Li, Tian Chen, A. Barrows, A. Horváth, J. Taube, P. Nghiem   +23 more
semanticscholar   +1 more source