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Merkel cell polyomavirus-specific and CD39⁺CLA⁺ CD8 T cells as blood-based predictive biomarkers for PD-1 blockade in Merkel cell carcinoma. [PDF]

Cell Rep Med
Ryu H, Bi TM, Pulliam TH, Sarkar K, Church CD, Kumar N, Mayer-Blackwell K, Jani S, Ramchurren N, Hansen UK, Hadrup SR, Fling SP, Koelle DM, Nghiem P, Newell EW.   +14 more
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Merkel Cell Polyomavirus and Human Merkel Cell Carcinoma

2020
Merkel cell polyomavirus (MCPyV) is the most recently discovered human oncogenic virus. MCPyV asymptomatically infects most of the human population. In the elderly and immunocompromised, however, it can cause a highly lethal form of human skin cancer called Merkel cell carcinoma (MCC).
Wei, Liu, Jianxin, You
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Merkel Cell Polyomavirus

2014
Merkel cell polyomavirus (MCV) is a recently discovered member of the polyomaviridae, a family of small DNA viruses that replicate in the nucleus of their host cell. MCV is one of at least 12 polyomaviruses that naturally infect humans, and furthermore one of four polyomaviruses that are known to cause severe human disease, predominantly in ...
Nicole Fischer, Adam Grundhoff
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Merkel Cell Polyomavirus

2011
Merkel cell carcinoma (MCC) is the most aggressive tumor of the skin. Nevertheless, until recently, almost only dermatologists were aware of MCC which was due to the rareness of this neuroendocrine carcinoma. This, however, changed in 2008 when a new polyomavirus, which was named Merkel cell polyomavirus (MCV or MCPyV), was found associated with MCC ...
David Schrama, Jürgen C. Becker
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Merkel Cell Polyomavirus (MCPyV)

2020
No abstract available.
Sofia, Asioli, Ricci, Costantino
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Detection of Merkel cell polyomavirus DNA in Merkel cell carcinomas

British Journal of Dermatology, 2009
Merkel cell carcinoma (MCC) is a rare, aggressive tumour for which an increasing incidence has been reported. A new human polyomavirus, Merkel cell polyomavirus (MCV), was recently isolated from these tumours by applying digital transcriptome subtraction methodology.To detect the presence or absence of MCV in MCCs and other, randomly selected neoplasms.
E, Varga, M, Kiss, K, Szabó, L, Kemény
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Merkel Cell Polyomavirus

American Journal of Surgical Pathology, 2009
The recently described Merkel cell polyomavirus (MCPyV) is reportedly present in 50% to 80% of Merkel cell carcinomas (MCC). Although the virus has been shown to be absent from other cutaneous neoplasms, its association with malignancies that are histologically similar to MCC, specifically small cell carcinoma of the lung and other high-grade ...
Eric J, Duncavage, Binh-Minh, Le, David, Wang, John D, Pfeifer   +3 more
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miRNA-34a underexpressed in Merkel cell polyomavirus-negative Merkel cell carcinoma

Virchows Archiv, 2014
Merkel cell polyomavirus (MCV) is frequently detectable in Merkel cell carcinoma (MCC) tumors, but the significance of MCV infection is not yet totally understood. Thus far, no key regulatory miRNA has been identified for MCC tumorigenesis. However, distinct miRNA expression profiles have been suggested for MCV-positive and MCV-negative tumors. We used
Sahi Helka, Mosakhani Neda, Knuutila Sakari, Bohling Tom, Koljonen Virve, Sahi Helka, Mosakhani Neda, Knuutila Sakari, Bohling Tom, Koljonen Virve   +9 more
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The Merkel Cell Polyomavirus and Its Involvement in Merkel Cell Carcinoma

Dermatologic Surgery, 2013
The discovery of the Merkel cell polyomavirus (MCV) in a large number of Merkel cell carcinomas (MCCs) has led to many investigations into its potential role as an oncovirus. Many studies have recently explored the differences between MCCs infected and not infected with MCV.To review the role of MCV in MCC and its potential to influence diagnosis ...
Kyle, Amber, Michael P, McLeod, Keyvan, Nouri   +2 more
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Merkel Cell Polyomavirus in Merkel Cell Carcinoma: Clinical and Therapeutic Perspectives

Seminars in Oncology, 2015
Merkel cell carcinoma (MCC) is a rare and often aggressive cutaneous cancer with a poor prognosis. The incidence of this cancer increases with age, immunodeficiency and sun exposure. Merkel cell polyomavirus (MCPyV), a new human polyomavirus identified in 2008, is detected in the majority of the MCCs and there is a growing body of evidence that healthy
Samimi-Gharaei, Mahtab, Gardair, Charlotte, Nicol, Jérôme, Arnold, Françoise, Touzé, Antoine, Coursaget, Pierre   +5 more
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