Results 131 to 140 of about 4,032 (162)

Prevalence of Merkel cell polyomavirus in Merkel cell carcinoma [PDF]

open access: yesModern Pathology, 2009
It has recently been shown that Merkel cell carcinoma, a rare and often lethal cutaneous malignancy, frequently harbors a novel clonally integrated polyomavirus aptly named Merkel cell polyomavirus. We aimed to study the prevalence of Merkel cell polyomavirus in cases of Merkel cell carcinoma, using specimens from formalin-fixed, paraffin-embedded ...
, Eric Duncavage, Duncavage Eric J
exaly   +3 more sources

Epigenetic Dysregulations in Merkel Cell Polyomavirus-Driven Merkel Cell Carcinoma [PDF]

open access: yesInternational Journal of Molecular Sciences, 2021
Merkel cell polyomavirus (MCPyV) is a small DNA virus with oncogenic potential. MCPyV is the causative agent of Merkel Cell Carcinoma (MCC), a rare but aggressive tumor of the skin. The role of epigenetic mechanisms, such as histone posttranslational modifications (HPTMs), DNA methylation, and microRNA (miRNA) regulation on MCPyV-driven MCC has ...
John Charles Rotondo   +2 more
exaly   +4 more sources

Merkel Cell Polyomavirus and Human Merkel Cell Carcinoma

2020
Merkel cell polyomavirus (MCPyV) is the most recently discovered human oncogenic virus. MCPyV asymptomatically infects most of the human population. In the elderly and immunocompromised, however, it can cause a highly lethal form of human skin cancer called Merkel cell carcinoma (MCC).
Wei, Liu, Jianxin, You
openaire   +2 more sources

The Merkel Cell Polyomavirus and Its Involvement in Merkel Cell Carcinoma

Dermatologic Surgery, 2013
The discovery of the Merkel cell polyomavirus (MCV) in a large number of Merkel cell carcinomas (MCCs) has led to many investigations into its potential role as an oncovirus. Many studies have recently explored the differences between MCCs infected and not infected with MCV.To review the role of MCV in MCC and its potential to influence diagnosis ...
Kyle, Amber   +2 more
openaire   +2 more sources

Detection of Merkel cell polyomavirus DNA in Merkel cell carcinomas

British Journal of Dermatology, 2009
Merkel cell carcinoma (MCC) is a rare, aggressive tumour for which an increasing incidence has been reported. A new human polyomavirus, Merkel cell polyomavirus (MCV), was recently isolated from these tumours by applying digital transcriptome subtraction methodology.To detect the presence or absence of MCV in MCCs and other, randomly selected neoplasms.
E, Varga, M, Kiss, K, Szabó, L, Kemény
openaire   +2 more sources

Merkel Cell Polyomavirus

2014
Merkel cell polyomavirus (MCV) is a recently discovered member of the polyomaviridae, a family of small DNA viruses that replicate in the nucleus of their host cell. MCV is one of at least 12 polyomaviruses that naturally infect humans, and furthermore one of four polyomaviruses that are known to cause severe human disease, predominantly in ...
Nicole Fischer, Adam Grundhoff
openaire   +1 more source

Merkel Cell Polyomavirus

2011
Merkel cell carcinoma (MCC) is the most aggressive tumor of the skin. Nevertheless, until recently, almost only dermatologists were aware of MCC which was due to the rareness of this neuroendocrine carcinoma. This, however, changed in 2008 when a new polyomavirus, which was named Merkel cell polyomavirus (MCV or MCPyV), was found associated with MCC ...
David Schrama, Jürgen C. Becker
openaire   +1 more source

Merkel Cell Polyomavirus

American Journal of Surgical Pathology, 2009
The recently described Merkel cell polyomavirus (MCPyV) is reportedly present in 50% to 80% of Merkel cell carcinomas (MCC). Although the virus has been shown to be absent from other cutaneous neoplasms, its association with malignancies that are histologically similar to MCC, specifically small cell carcinoma of the lung and other high-grade ...
Eric J, Duncavage   +3 more
openaire   +2 more sources

Detection of Merkel cell polyomavirus in Merkel cell carcinoma and Kaposi's sarcoma

Journal of Medical Virology, 2009
AbstractMerkel cell carcinoma is a rare malignancy that sometimes occurs in the skin of elderly people. Recently, a new human polyomavirus, Merkel cell polyomavirus (MCPyV) was identified in Merkel cell carcinoma. In the present study, MCPyV‐DNA was detected in 6 of 11 (55%) cases of Merkel cell carcinoma by nested PCR and real‐time PCR. Histologically,
Harutaka Katano
exaly   +3 more sources

Merkel Cell Polyomavirus (MCPyV)

2020
No abstract available.
Sofia, Asioli, Ricci, Costantino
openaire   +2 more sources

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