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Regulation of drug resistance and virulence of Acinetobacter baumannii by quorum sensing system under antibiotic pressure [PDF]

Frontiers in Microbiology
IntroductionAcinetobacter baumannii is a formidable pathogen renowned for its role in hospital-acquired infections. In recent years, largely due to antibiotic abuse and other reasons, bacteria are frequently exposed to sub-minimum inhibitory ...
Xingyu Jiang, Xuchun Shan, Xiaomeng Yang, Xin Zhang, Yang Xiang, Yan Chen, Zhaohui Ni   +6 more
doaj   +2 more sources

Practical utility of meropenem therapeutic drug monitoring: a systematic review of evidence for clinical application [PDF]

Frontiers in Pharmacology
Background and purposeTherapeutic Drug Monitoring (TDM) is advocated to optimize antibiotic therapy, yet its efficacy remains debated. This systematic review and meta-analysis evaluates TDM’s impact on meropenem therapy, focusing on treatment efficacy ...
Yi-Chang Zhao, Yi-Chang Zhao, Jia-Yi Liu, Jia-Yi Liu, Jia-Kai Li, Jia-Kai Li, Huai-Yuan Liu, Huai-Yuan Liu, Zhi-Hua Sun, Zhi-Hua Sun, Bi-Kui Zhang, Bi-Kui Zhang, Miao Yan, Miao Yan   +13 more
doaj   +2 more sources

Comparison of Intravenous Microdialysis and Standard Plasma Sampling for Monitoring of Vancomycin and Meropenem Plasma Concentrations—An Experimental Porcine Study

Antibiotics, 2023
Microdialysis is a catheter-based method suitable for dynamic sampling of unbound antibiotic concentrations. Intravenous antibiotic concentration sampling by microdialysis has several advantages and may be a superior alternative to standard plasma ...
Johanne Gade Lilleøre, Sofus Vittrup, Sara Kousgaard Tøstesen, Pelle Hanberg, Maiken Stilling, Mats Bue   +5 more
doaj   +1 more source

Biapenem Activity Against Meropenem-Resistant Klebsiella pneumoniae and Pseudomonas aeruginosa

Антибиотики и Химиотерапия, 2022
Currently, the diversity of resistant strains with a certain set of resistance mechanisms is growing, and the frequency of their distribution is increasing.
E. M. Gordina, S. A. Bozhkova, V. V. Shabanova   +2 more
doaj   +1 more source

Fast and Sensitive Method for Simultaneous Quantification of Meropenem and Vaborbactam in Human Plasma Microsamples by Liquid Chromatography–Tandem Mass Spectrometry for Therapeutic Drug Monitoring

Antibiotics, 2023
Meropenem (MRP)-Vaborbactam (VBR) is a novel beta-lactam/beta-lactamase inhibitor used for the management of difficult-to-treat Gram-negative infections.
Rossella Barone, Matteo Conti, Beatrice Giorgi, Milo Gatti, Pier Giorgio Cojutti, Pierluigi Viale, Federico Pea   +6 more
doaj   +1 more source

Preparation, Physicochemical Characterization, Antimicrobial Effects, Biocompatibility and Cytotoxicity of Co-Loaded Meropenem and Vancomycin in Mesoporous Silica Nanoparticles

Biomedicines, 2023
Mesoporous silica nanoparticles (MSNPs) have been reported as an effective system to co-deliver a variety of different agents to enhance efficiency and improve biocompatibility.
Mina Yekani, Robab Azargun, Simin Sharifi, Javid Sadri Nahand, Alka Hasani, Hadi Ghanbari, Zahra Sadat Seyyedi, Mohammad Yousef Memar, Solmaz Maleki Dizaj   +8 more
doaj   +1 more source

Dried Plasma Spot Based LC–MS/MS Method for Monitoring of Meropenem in the Blood of Treated Patients

Molecules, 2022
Meropenem (MER) is widely used to treat complicated and serious infections. Therapeutic drug monitoring (TDM) provides a valid clinical tool to avoid suboptimal concentrations and dose–related adverse reactions.
Haiwei Cao, Yi Jiang, Shaomin Wang, Haihuan Cao, Yanyan Li, Jing Huang   +5 more
doaj   +1 more source

Evaluation of a Meropenem and Piperacillin Monitoring Program in Intensive Care Unit Patients Calls for the Regular Assessment of Empirical Targets and Easy-to-Use Dosing Decision Tools

Antibiotics, 2022
The drug concentrations targeted in meropenem and piperacillin/tazobactam therapy also depend on the susceptibility of the pathogen. Yet, the pathogen is often unknown, and antibiotic therapy is guided by empirical targets.
Ferdinand Anton Weinelt, Miriam Songa Stegemann, Anja Theloe, Frieder Pfäfflin, Stephan Achterberg, Franz Weber, Lucas Dübel, Agata Mikolajewska, Alexander Uhrig, Peggy Kiessling, Wilhelm Huisinga, Robin Michelet, Stefanie Hennig, Charlotte Kloft   +13 more
doaj   +1 more source

Effect of Different Approaches to Antimicrobial Therapy with Cefmetazole and Meropenem on the Time to Defervescence in Non-Severe Extended-Spectrum β-Lactamase-Producing Escherichia coli Bacteremia

Infectious Disease Reports, 2023
Carbapenems are antimicrobial agents commonly used to treat extended-spectrum β-lactamase (ESBL)-producing bacteria. Although cefmetazole (CMZ) is considered effective for ESBL-producing Escherichia coli (ESBL-EC) bacteremia, previous studies showed its ...
Takanobu Hoshi, Satoshi Fujii, Kei Watanabe, Yuta Fukumura, Koji Miyazaki, Madoka Takahashi, Sakae Taniguchi, Shingo Kimura, Arisa Saito, Naoki Wada, Masaji Saijo, Kazunori Yamada, Kuninori Iwayama, Marie Itaya, Hideki Sato   +14 more
doaj   +1 more source

Prevalence of Aerobic Organisms in Surgical Site and Ulcerations at a Tertiary Rural Hospital in Mandya, Karnataka, India

International Journal of Anatomy Radiology and Surgery, 2022
Introduction: In an era in which the cost of treatment is an increasing source of concern in wound management in surgery, wound infection increases costs and hospital stay.
Rochelle D’Souza, Shilpashree Channasandra Shekar, Suhas Narayanswamy Gowda, N Naveen   +3 more
doaj   +1 more source