Results 61 to 70 of about 2,271 (197)

Biomimetic Synthesis of Meroterpenoids by Dearomatization‐Driven Polycyclization

Angewandte Chemie, 2019
AbstractA biomimetic route to farnesyl pyrophosphate and dimethyl orsellinic acid (DMOA)‐derived meroterpenoid scaffolds has yet to be reported despite great interest from the chemistry and biomedical research communities. A concise synthetic route with the potential to access DMOA‐derived meroterpenoids is highly desirable to create a library of ...
Zachary Powers, Adam Scharf, Andrea Cheng, Feng Yang, Martin Himmelbauer, Takaaki Mitsuhashi, Lena Barra, Yoshimasa Taniguchi, Takashi Kikuchi, Makoto Fujita, Ikuro Abe, John A. Porco   +11 more
openaire   +5 more sources

Shikonin: From Biosynthesis and Pharmacological Mechanisms to Translational Safety and Drug Delivery

ChemBioChem, Volume 27, Issue 21, 12 November 2026.
Shikonin, biosynthesised in Boraginaceae roots from phenylalanine‐derived PHB and isoprenoid GPP, modulates redox balance, cellular stress, signalling pathways, and regulated cell death. Preclinical studies support diverse pharmacological activities, while nanocarriers improve dispersion and delivery.
Namini Joshi, Prabhakar Semwal, Balwant Rawat, Ravendra Kumar, Mozaniel Santana de Oliveira, Nishant Rai, Janhvi Mishra Rawat   +6 more
wiley   +1 more source

Bioactive Compounds from Terrestrial and Marine-Derived Fungi of the Genus Neosartorya †

Molecules, 2022
Fungi comprise the second most species-rich organism group after that of insects. Recent estimates hypothesized that the currently reported fungal species range from 3.5 to 5.1 million types worldwide. Fungi can grow in a wide range of habitats, from the
Joana D. M. de Sá, Decha Kumla, Tida Dethoup, Anake Kijjoa   +3 more
doaj   +1 more source

Structure and Biosynthesis of Mangotoxin Produced by the Plant Pathogen Pseudomonas syringae

Angewandte Chemie International Edition, Volume 65, Issue 45, 2 November 2026.
The structure of mangotoxin remained elusive for over two decades. Here, mangotoxin was isolated from the native producer, Pseudomonas syringae pv. syringae, and was determined to be an alkyne‐containing dipeptide. Mangotoxin inhibited the growth of multidrug‐resistant human pathogen Klebsiella pneumoniae.
Alexis H. Murray, Sohan Hazra, Ryan W. Mull, Erinn M. O'Neill, Bo Li   +4 more
wiley   +1 more source

Recent Chemical Methodology Advances in the Total Synthesis of Meroterpenoids

Acta Chimica Slovenica, 2021
Heterogeneity of meroterpenoids arising from their dual biosynthetic origins is constantly provoking synthetic chemists to utilize their ingenuity and revise their retrosynthetic logic.
David Sarlah, Jan Petrovčič, Chad Nicholas Ungarean   +2 more
doaj   +1 more source

Investigations of the Evolved Molecular Basis for Terpenoid Biosynthesis in Marine Sponges

Advanced Science, Volume 13, Issue 62, 9 November 2026.
Confirming and extending a previous observation in another Bubarida sponge, genomic and functional analyses of A. cavernosa reveal that sponges retain the mevalonate pathway and employ single α‐domain T1TSs and UbiA‐type TSs for terpenoid biosynthesis. The absence of T1TSs clustering with other biosynthetic genes tentatively suggests, based on limited ...
Fangyan Chen, Bao Chen, Wenhui Zhang, Guifang Sun, Yao Zhao, Jianpeng Zhang, Baofu Xu   +6 more
wiley   +1 more source

Marine-Derived Penicillium purpurogenum Reduces Tumor Size and Ameliorates Inflammation in an Erlich Mice Model

Marine Drugs, 2020
Background: This study addresses the antitumoral properties of Penicillium purpurogenum isolated from a polluted lagoon in Northeastern Brazil. Methods: Ethyl Acetate Extracellular Extract (EAE) was used.
Amanda Mara Teles, Leticia Prince Pereira Pontes, Sulayne Janayna Araújo Guimarães, Ana Luiza Butarelli, Gabriel Xavier Silva, Flavia Raquel Fernandes do Nascimento, Geusa Felipa de Barros Bezerra, Carla Junqueira Moragas-Tellis, Rui Miguel Gil da Costa, Marcos Antonio Custódio Neto da Silva, Fernando Almeida-Souza, Kátia da Silva Calabrese, Ana Paula Silva Azevedo-Santos, Maria do Desterro Soares Brandão Nascimento   +13 more
doaj   +1 more source

Two Separate Gene Clusters Encode the Biosynthetic Pathway for the Meroterpenoids Austinol and Dehydroaustinol in Aspergillus nidulans [PDF]

, 2012
Meroterpenoids are a class of fungal natural products that are produced from polyketide and terpenoid precursors. An understanding of meroterpenoid biosynthesis at the genetic level should facilitate engineering of second-generation molecules and ...
Entwistle, Ruth A., Jui-Hsiang Hung (313316), Hsien-Chun Lo (2022889), Edyta Szewczyk (2103619), Clay C. C. Wang (313310), Manmeet Ahuja (1956250), Chiang, Yi-Ming, Wang, Clay C. C., Hung, Jui-Hsiang, Chun-Jun Guo (401559), Yi-Ming Chiang (1312392), Guo, Chun-Jun, Berl R. Oakley (183341), Lo, Hsien-Chun, Ahuja, Manmeet, Szewczyk, Edyta, Ruth Entwistle (1951291), Oakley, Berl R.   +17 more
core   +1 more source

Biosynthetic Pathways and Regulation of Antibacterial Compounds From Endophytic Fungi: From Chemistry to Genomics and Biotechnology

Chemistry &Biodiversity, Volume 23, Issue 11, November 2026.
Endophytic fungi encode abundant cryptic biosynthetic gene clusters that remain largely silent under conventional cultivation. This review highlights how genome mining, multi‐omics, and cluster activation strategies bridge the BGC‐to‐metabolite gap, enabling the discovery of structurally diverse antibacterial natural products with activity against ...
Farkhod Eshboev, Abubakar Siddiq Salihu, Lobar Khayrullaeva, Doniyor Khamdamov, Alex X. Gao, Kamila Mardieva, Wan Mohd Nuzul Hakimi Wan Salleh, Shakhnoz Azimova, Karl W. K. Tsim   +8 more
wiley   +1 more source

Drychampones A–C: Three Meroterpenoids from Dryopteris championii

, 2016
Three novel sesquiterpenoid-based meroterpenoids, drychampones A–C (1–3, respectively), were isolated from Dryopteris championii. Compounds 1 and 3 possessed a novel carbon skeleton which was constructed by an 11/6/6 ring system coupled with a pyronone ...
Neng-Hua Chen (1472803), Yu-Bo Zhang (1472812), Guo-Qiang Li (625328), Lin Jiang (217766), Yao-Lan Li (1472815), Guo-Cai Wang (625329), Si-Qi Jiang (3117123), Xiao-Jun Huang (1447690)   +7 more
core   +1 more source