Results 61 to 70 of about 2,951 (216)

Natural Products as Modulators of ABC Transporters in Breast Cancer

Phytotherapy Research, Volume 40, Issue 7, Page 4611-4637, July 2026.
ABSTRACT Breast cancer remains a significant global health challenge, with high incidence and mortality rates despite advancements in early detection and treatment. Multidrug resistance (MDR), particularly in aggressive subtypes like triple‐negative breast cancer (TNBC), continues to hinder effective therapy.
Yoganishalini Sagadevan, Reyhaneh Farghadani, Ammu K. Radhakrishnan   +2 more
wiley   +1 more source

Cationic amphiphilic meroterpenoids: synthesis, antibacterial, antifungal and mutagenic activity

Chimica Techno Acta
In this research, using the thia-Michael reaction, cationic amphiphilic meroterpenoids containing fragments of mono- and sesquiterpenoids were synthesized.
Alan Akhmedov, Rustem Gamirov, Yulia Panina, Alina Baklagina, Evgenia Sokolova, Pavel Zelenikhin, Olga Babaeva, Vasily Babaev, Dmitriy Shurpik, Ivan Stoikov   +9 more
doaj   +1 more source

Asperversins A and B, Two Novel Meroterpenoids with an Unusual 5/6/6/6 Ring from the Marine-Derived Fungus Aspergillus versicolor

Marine Drugs, 2018
Asperversins A (1) and B (2), two novel meroterpenoids featuring an uncommon 5/6/6/6 ring system, along with five new analogues (3–7) and a known compound asperdemin (8), were obtained from the marine-derived fungus Aspergillus versicolor.
Huaqiang Li, Weiguang Sun, Mengyi Deng, Changxing Qi, Chunmei Chen, Hucheng Zhu, Zengwei Luo, Jianping Wang, Yongbo Xue, Yonghui Zhang   +9 more
doaj   +1 more source

The Potential Alleviating Property Against NAFLD by Ganoderma lucidum With Bacteria‐Enzyme Synergistic Fermentation

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
A bacteria‐enzyme synergistic fermentation process using Lactobacillus rhamnosus was developed to produce fermented Ganoderma lucidum broth (FBG), which significantly enriched ganoderic acid F compared to water extraction. In FFA‐induced HepG2 cells, FBG alleviated NAFLD‐related damage by reducing lipid deposition, ROS, MDA, TC, TG, and LDL‐C, while ...
Manhui Sun, Kecheng Li, Zhenzhen Wang, Jing Dai, Jianwei Mao, Min Cai, Ruyi Sha   +6 more
wiley   +1 more source

Bioactive Prenyl- and Terpenyl-Quinones/Hydroquinones of Marine Origin †

Marine Drugs, 2018
The sea is a rich source of biological active compounds, among which terpenyl-quinones/hydroquinones constitute a family of secondary metabolites with diverse pharmacological properties.
Pablo A. García, Ángela P. Hernández, Arturo San Feliciano, Mª Ángeles Castro   +3 more
doaj   +1 more source

Meroterpenoids and alkaloids from Ganoderma australe

Natural Product Research, 2019
Two new mertoterpenoids, australins A (1) and B (2), and a new alkaloid, australine (4), together with five known compounds (3, 5–8) were isolated from the fruiting bodies of Ganoderma australe. Their structures including absolute configurations were assigned by using spectroscopic methods and electronic circular dichroism (ECD) calculations.
Jiao-Jiao, Zhang, Yun, Dong, Fu-Ying, Qin, Yong-Ming, Yan, Yong-Xian, Cheng   +4 more
openaire   +2 more sources

Design, Optimization and Mechanistic Insights Into Terpenoid‐Derived Inhibitors of Protein Kinase C Iota

Chemical Biology &Drug Design, Volume 107, Issue 6, June 2026.
In this study, we identified a synthetic naphthoquinone merosesquiterpene as a potent PKCι inhibitor, emerging as the most strongly inhibited kinase within a panel of 410 human kinases. Structure–activity relationship (SAR) studies using a focused library of terpenoid analogues highlighted the critical role of the naphthoquinone core and the aromatic ...
Rachid Chahboun, Fernando Rodríguez‐Serrano, Ángel Bueno, Nuria Mut‐Salud, Ramón Alvarez‐Manzaneda, Enrique Alvarez‐Manzaneda, Antonio Fernández   +6 more
wiley   +1 more source

Depicting the Chemical Diversity of Bioactive Meroterpenoids Produced by the Largest Organism on Earth.

Angewandte Chemie
In this investigation, we explored the diversity of melleolide-type meroterpenoids produced by Armillaria ostoyae, one of the largest and oldest organisms on Earth, using extracts from liquid and solid fermentation media.
Sebastian Pfütze, E. Charria-Girón, Esther Schulzke, Rita Toshe, A. Khonsanit, Raimo Franke, F. Surup, M. Brönstrup, Marc Stadler   +8 more
semanticscholar   +1 more source

Mitochondrial Homeostasis in Pancreatic β Cell Function: Mechanisms and Therapeutic Targets for Diabetes

Journal of Diabetes, Volume 18, Issue 5, May 2026.
This review highlights mitochondrial dysfunction as a central driver of pancreatic β cell failure in diabetes, caused by disrupted mitochondrial quality control (MQC), oxidative stress, and impaired organelle communication. Emerging therapies, such as DRAK2 inhibitors and metabolic reprogramming agents, show promise in restoring β cell function by ...
Ruihan Li, Bingqian Zhang, Yuxin Zhang, Yang Yang, Yuting Lu, Jingya Li   +5 more
wiley   +1 more source

Context‐Dependent Chemoselectivity of Aromatic C‐Methyltransferases

ChemBioChem, Volume 27, Issue 8, April 2026.
Chemoselectivity is context‐dependent: The SAM‐dependent C‐MTs SfmM2 and NapB5 from streptomycetes catalyze the C‐ and/or O‐dimethylation of aromatic substrates, including l‐tyrosine and flavonoids. C‐methylation activity requires precise substrate recognition and positioning to ensure proximity between the target carbon nucleophile and the methyl ...
Juliane Breiltgens, Ziruo Zou, Sascha Ferlaino, Jennifer N. Andexer, Michael Müller   +4 more
wiley   +1 more source