Results 41 to 50 of about 9,412 (255)

Preformulation Considerations Development and Evaluation of Mesalamine Loaded Polysaccharide-Based Complex Mucoadhesive Beads for Colon Targeting

, 2021
Background: Inflammatory bowel disease (IBD) is a chronic inflammatory disease of large intestine consisting of ulcerative colitis and Crohn’s disease. Mesalamine is a first line drug use for the treatment but it has drawback of low water solubility and ...
Rohitas Deshmukh, Ranjit Kumar
semanticscholar   +1 more source

A Randomized Single Blind Parallel Group Study Comparing Monoherbal Formulation Containing Holarrhena antidysenterica Extract with Mesalamine in Chronic Ulcerative Colitis Patients

Ancient Science of Life, 2016
Background: Incidences of side effects and relapses are very common in chronic ulcerative colitis patients after termination of the treatment. Aims and Objectives: This study aims to compare the treatment with monoherbal formulation of Holarrhena ...
Sarika Johari, Tejal Gandhi
doaj   +1 more source

Variability in intestinal drug metabolizing enzymes and transporters in Crohn's disease and potential impact on oral drug absorption

British Journal of Clinical Pharmacology, EarlyView.
Aims The aim of study was to generate quantitative data on the abundance of drug‐metabolizing enzymes and transporters (DMETs) in inflamed and non‐inflamed Crohn's disease (CD) ileum and colon, for incorporation into physiologically based pharmacokinetic (PBPK) models, enabling prediction of oral drugs' pharmacokinetics (PK) perturbation in CD patients.
Sarah Alrubia, Brahim Achour, Zubida M. Al‐Majdoub, Amin Rostami‐Hodjegan, Jill Barber   +4 more
wiley   +1 more source

Mesalamine-induced myopericarditis - A case report [PDF]

Revista Española de Enfermedades Digestivas, 2016
Myopericarditis has occasionally been reported as a side effect of mesalamine in patients with inflammatory bowel disease. We present a 20-year-old woman with ulcerative colitis admitted with chest pain. After thorough investigation she was diagnosed with myopericarditis potentially related to mesalamine.
Luís Araújo-Correia, Samuel Raimundo Fernandes, S Bernardo   +2 more
openaire   +4 more sources

Efficacy and Tolerance of 5-Aminosalicylic Acid Suppositories in the Treatment of Ulcerative Proctitis: A Review of Two Double-Blind, Placebo Controlled Trials

Canadian Journal of Gastroenterology, 1990
The efficacy and tolerance of 500 mg 5-aminosalicylic acid (mesalamine) suppositories in the treatment of ulcerative proctitis were assessed in two double-blind, placebo controlled studies of six weeks' duration, involving a total of 173 patients.
CN Williams
doaj   +1 more source

Mesalamine induced hepatotoxicity. Is mesalamine safe?

Revista Española de Enfermedades Digestivas
Dear Editor: Mesalamine is a medication used widely in the treatment of patients with inflammatory bowel disease. Although mesalamine is considered safe, hepatotoxicity has been reported with an incidence of 0-4%. We present the clinical picture of a patient with hepatotoxicity due to mesalamine.
Javier, Pérez-Valenzuela, Lorena, Castro Solari, Rodrigo, Quera, Luis, Contreras   +3 more
openaire   +2 more sources

Prevalence and trend of anemia in children with inflammatory bowel disease: A national register‐based cohort study

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives We determined the prevalence of anemia and its characteristics in children with newly diagnosed inflammatory bowel disease (IBD) and investigated its trend during follow‐up. Methods An observational, multicenter cohort study of IBD children with anemia at the diagnosis enrolled in the Italian Society of Pediatric Gastroenterology ...
Giulia D'Arcangelo, Marco Brecciaroli, Giulia Gagliostro, Dalila Auletta, Salvatore Pellegrino, Serena Arrigo, Francesco Graziano, Erasmo Miele, Maria Teresa Illiceto, Patrizia Alvisi, Dario Dilillo, Costantino De Giacomo, Paolo Lionetti, Maria Pastore, Mara Cananzi, Matteo Bramuzzo, Roberto Panceri, Lorenzo Norsa, Marina Aloi, The SIGENP IBD Working Group   +19 more
wiley   +1 more source

Medication adherence and persistence in the treatment of Canadian ulcerative colitis patients: analyses with the RAMQ database

BMC Gastroenterology, 2013
Background Although high non-adherence to medication has been noticed for ulcerative colitis (UC), little is known about adherence to mesalamine treatments and determinants that can predict adherence.
Lachaine Jean, Yen Linnette, Beauchemin Catherine, Hodgkins Paul   +3 more
doaj   +1 more source

The Polyphosphate Kinase of Escherichia coli Is Required for Full Production of the Genotoxin Colibactin

mSphere, 2020
Colibactin induces DNA damage in mammalian cells and has been linked to the virulence of Escherichia coli and the promotion of colorectal cancer (CRC). By looking for mutants attenuated in the promoter activity of clbB encoding one of the key enzymes for
Min Tang-Fichaux, Camille V. Chagneau, Nadège Bossuet-Greif, Jean-Philippe Nougayrède, Éric Oswald, Priscilla Branchu   +5 more
doaj   +1 more source

Differential diagnosis problem of pulmonary changes in ulcerative colitis [PDF]

Vojnosanitetski Pregled, 2010
Introduction. Inflammatory intestinal diseases are often accompanied with extraintestinal and even pulmonary manifestations. The treatment of these intestinal diseases includes sulphasalazine and mesalazine, which may have undesirable allergic and other ...
Đurić Mirna, Považan Đorđe, Sečen Svetozar, Jović Jelena   +3 more
doaj   +1 more source