Results 71 to 80 of about 26,579 (349)

Macrophages Mediate Mesoscale Brain Mechanical Homeostasis

Advanced Materials, EarlyView.
We investigated the role of infiltrating immune cells in sculpting the developing brain. Using Brillouin microscopy and active microrheology, we found microglia actively maintain tissue viscoelasticity. Moreover, colony stimulating factor one receptor (CSF1R)‐driven stromal remodeling alters brain mechanics in vivo. These findings link immune activity,
Woong Young So, Bailey Johnson, Patricia B. Gordon, Kevin S. Bishop, Hyeyeon Gong, Hannah A Burr, Jack Rory Staunton, Chenchen Handler, Khanh Loan Ly, Raman Sood, Giuliano Scarcelli, Kandice Tanner   +11 more
wiley   +1 more source

The CK1 gene family: expression patterning in zebrafish development

Biological Research, 2007
Protein kinase CK1 is a ser/thr protein kinase family which has been identified in the cytosol cell fraction, associated with membranes as well as in the nucleus.
AMELINA ALBORNOZ, JOSÉ M YÁÑEZ, CLAUDIA FOERSTER, CELESTE AGUIRRE, LUISA PEREIRO, VERÓNICA BURZIO, MAURICIO MORAGA, ARIEL E REYES, MARCELO ANTONELLI   +8 more
doaj  

Metformin Restores Mitochondrial Function and Neurogenesis in POLG Patient‐Derived Brain Organoids

Advanced Science, EarlyView.
Patient‐derived POLG‐mutant cortical organoids reveal neuronal subtype‐specific mitochondrial and synaptic defects, with dopaminergic neurons most affected. Metformin treatment restores neuronal identity, mitochondrial function, and excitability, increased mtDNA maintenance, and reprogrammed metabolism via TCA and redox pathways.
Zhuoyuan Zhang, Tsering Yangzom, Ning Lu, Shenglong Deng, Xianglu Xiao, Guang Yang, Kristina Xiao Liang   +6 more
wiley   +1 more source

Schmallenberg virus pathogenesis, tropism and interaction with the innate immune system of the host [PDF]

, 2013
Schmallenberg virus (SBV) is an emerging orthobunyavirus of ruminants associated with outbreaks of congenital malformations in aborted and stillborn animals.
A Bridgen, A Bridgen, A Kohl, AC Lowen, AJ Della-Porta, Alain Kohl, Andrew Shaw, Anna Janowicz, AR Elbers, B Hoffmann, B Xu, CA Evans, Catherine Lamm, Claudio Murgia, CM Southam, CT Walter, D Thomas, DH Cybinski, Esther Schnettler, Eva McGregor, F Arnaud, Friedemann Weber, G Barry, G Blakqori, G Blakqori, G Neumann, Gerald Barry, Ilaria M. Piras, JI Gillespie, JL Farmer, K Kupferschmidt, K Peperkamp, K Terasaki, K Wernike, KE Jones, Kerstin Hahn, KV Goller, LD Rasmussen, M Beer, M Bouloy, M Caporale, M Dominguez, M Palmarini, M Ratinier, M Spiegel, M Varela, Mandy Glass, Marco Caporale, Mariana Varela, Martin Beer, Massimo Palmarini, Melanie McFarlane, MJ Killip, MM Garigliany, MM Garigliany, NR Saunders, OR Causey, P Vialat, PJ Hotez, PT Leisnham, R Muller, RS Azevedo, S Shimshony, SE Randolph, T Ikegami, T Yanase, UJ Buchholz, V Herder, Vanessa Herder, VH Leonard, Wolfgang Baumgärtner, X Shi, Y Ogawa, YK Liao   +73 more
core   +9 more sources

The Effect of Exercise with and without Consumption of Hydroalcoholic Extract of Eriobotrya Japonica Flower on Mesencephalic Astrocyte-derived Neurotrophic Factor in the Cerebellum of Rats Subjected to6-Hydroxydopamine

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2015
Background and Objectives:Previous researchs has shown that exercise and antioxidants consumption have positive effect on oxidative stress. Therefore, this study was carried out aiming at investigating the effects of 12 weeks of exercise on a running ...
Raziyeh Mohammadi, Zia Fallah Mohammadi, Molook Mohammadi, Aboalghasem Taghavi Holagh   +3 more
doaj  

Comparison of gene expression profile in embryonic mesencephalon and neuronal primary cultures.

PLoS ONE, 2009
In the mammalian central nervous system (CNS) an important contingent of dopaminergic neurons are localized in the substantia nigra and in the ventral tegmental area of the ventral midbrain.
Dario Greco, Floriana Volpicelli, Antonio Di Lieto, Damiana Leo, Carla Perrone-Capano, Petri Auvinen, Umberto di Porzio   +6 more
doaj   +1 more source

Early- and late-migrating cranial neural crest cell populations have equivalent developmental potential in vivo [PDF]

, 1997
We present the first in vivo study of the long-term fate and potential of early-migrating and late-migrating mesencephalic neural crest cell populations, by performing isochronic and heterochronic quail-to-chick grafts.
Baker, Clare V. H., Bronner-Fraser, Marianne, Le Douarin, Nicole M., Teillet, Marie-Aimée   +3 more
core  

Human midbrain precursors activate the expected developmental genetic program and differentiate long-term to functional A9 dopamine neurons in vitro. Enhancement by Bcl-XL [PDF]

, 2012
Understanding the molecular programs of the generation of human dopaminergic neurons (DAn) from their ventral mesencephalic (VM) precursors is of key importance for basic studies, progress in cell therapy, drug screening and pharmacology in the context ...
Abeliovich, Alavian, Alberto Martínez-Serrano, Almqvist, Andersson, Andersson, Ang, Arenas, Bayer, Bonilla, Brundin, Brundin, Burbach, Cacci, Christophersen, Chung, Courtois, Donato, Elise T. Courtois, Emma G. Seiz, Ferri, Freeman, Gale, Garcia-Garcia, Hebsgaard, Isabel Liste Noya, Jacobs, Jan Tønnesen, Jensen, Kadkhodaei, Kallur, Kele, Khan, Kim, Kim, Kim, Ko, Krabbe, Lepski, Li, Lin, Lindvall, Lindvall, Lindvall, Lindvall, Liste, Liste, Lotharius, Maciaczyk, Martinat, Martínez-Serrano, Merab Kokaia, Milagros Ramos-Gómez, Miljan, Mo, Nakatani, Nelander, Olanow, Omodei, Ono, Orme, Ostenfeld, Osumi, Papanikolaou, Park, Perlmann, Popko, Prakash, Prakash, Pruszak, Puelles, Puelles, Roybon, Rubio, Sgado, Sgado, Smidt, Smidt, Sonnier, Tonnesen, Tzschentke, Vernay, Villa, Yan, Zhang   +84 more
core   +4 more sources

Isthmus organizer and regionalization of the mesencephalon and metencephalon

The International Journal of Developmental Biology, 2005
The brain vesicles that are formed at an early stage of neural development are the fundamentals of the brain plan. Heterotopic transplantation revealed that the diencephalon could change its fate when juxtaposed to the isthmus (mes-metencephalic boundary), which indicated that the isthmus functions as an organizer for the mesencephalon and ...
Harukazu, Nakamura, Yuji, Watanabe
openaire   +3 more sources

Cortico‐Striatal‐Midbrain Circuit Dysregulation Underlying MK‐801 Induced Impulsivity and the Ameliorative Effects of SEP

Advanced Science, EarlyView.
Impulsivity is a symptom across multiple psychiatric disorders, yet its neural basis remains elusive. This study shows that the NMDAR antagonist MK‐801 elevates dopamine release and disrupts neuronal selectivity in the nucleus accumbens, leading to impulsive behavior.
Xueru Wang, Qinyu Li, Zijie Li, Xuejiao Wang, Hui Yuan, Pingting Yang, Ling Qin   +6 more
wiley   +1 more source