Results 81 to 90 of about 26,322 (346)

Human midbrain precursors activate the expected developmental genetic program and differentiate long-term to functional A9 dopamine neurons in vitro. Enhancement by Bcl-XL [PDF]

, 2012
Understanding the molecular programs of the generation of human dopaminergic neurons (DAn) from their ventral mesencephalic (VM) precursors is of key importance for basic studies, progress in cell therapy, drug screening and pharmacology in the context ...
Abeliovich, Alavian, Alberto Martínez-Serrano, Almqvist, Andersson, Andersson, Ang, Arenas, Bayer, Bonilla, Brundin, Brundin, Burbach, Cacci, Christophersen, Chung, Courtois, Donato, Elise T. Courtois, Emma G. Seiz, Ferri, Freeman, Gale, Garcia-Garcia, Hebsgaard, Isabel Liste Noya, Jacobs, Jan Tønnesen, Jensen, Kadkhodaei, Kallur, Kele, Khan, Kim, Kim, Kim, Ko, Krabbe, Lepski, Li, Lin, Lindvall, Lindvall, Lindvall, Lindvall, Liste, Liste, Lotharius, Maciaczyk, Martinat, Martínez-Serrano, Merab Kokaia, Milagros Ramos-Gómez, Miljan, Mo, Nakatani, Nelander, Olanow, Omodei, Ono, Orme, Ostenfeld, Osumi, Papanikolaou, Park, Perlmann, Popko, Prakash, Prakash, Pruszak, Puelles, Puelles, Roybon, Rubio, Sgado, Sgado, Smidt, Smidt, Sonnier, Tonnesen, Tzschentke, Vernay, Villa, Yan, Zhang   +84 more
core   +4 more sources

Neural Response Reliability as a Marker of the Transition of Neural Codes along Auditory Pathways

Advanced Science, EarlyView.
Decoding sound from neural activity in mice reveals a striking shift in how the brain encodes sound: from precise but redundant timing codes in early auditory areas to efficient, synergistic rate‐based codes in the cortex. This transformation highlights a robust neural strategy for turning complex acoustic input into coherent perception across the ...
Alexa Buck, Typhaine Dupont, Rupert Andrews Cavanagh, Olivier Postal, Jérôme Bourien, Jean‐Luc Puel, Nicolas Michalski, Boris Gourévitch   +7 more
wiley   +1 more source

The Effect of Exercise with and without Consumption of Hydroalcoholic Extract of Eriobotrya Japonica Flower on Mesencephalic Astrocyte-derived Neurotrophic Factor in the Cerebellum of Rats Subjected to6-Hydroxydopamine

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2015
Background and Objectives:Previous researchs has shown that exercise and antioxidants consumption have positive effect on oxidative stress. Therefore, this study was carried out aiming at investigating the effects of 12 weeks of exercise on a running ...
Raziyeh Mohammadi, Zia Fallah Mohammadi, Molook Mohammadi, Aboalghasem Taghavi Holagh   +3 more
doaj  

Expression of three GnRH receptors in specific tissues in male and female sea lampreys Petromyzon marinus at three distinct life stages [PDF]

, 2013
Two recently cloned gonadotropin-releasing hormone (GnRH) receptors (lamprey GnRH-R-2 and lamprey GnRH-R-3) along with lamprey (l) GnRH-R-1 were shown to share similar structural features and amino acid motifs common to other vertebrate receptors.
Daukss, Dana M., Decatur, Wayne A., Hall, Jeffrey A., Hayes, Mary K.   +3 more
core   +1 more source

Possible multiple evolution of indirect telencephalo-cerebellar pathways in teleosts: studies in Carassius auratus and Pantodon buchholzi [PDF]

, 1993
Among vertebrates, telencephalo-pontine systems exist only in birds and mammals. However, three nuclei in the diencephalon and mesencephalon of teleost fishes have been indicated — analogous to the pons — to represent relay stations between telencephalon
Meyer, Dietrich L., Wullimann, Mario F.
core   +1 more source

SpaBatch: Deep Learning‐Based Cross‐Slice Integration and 3D Spatial Domain Identification in Spatial Transcriptomics

Advanced Science, EarlyView.
SpaBatch is an end‐to‐end multi‐slice spatial transcriptomics data integration framework. It simultaneously performs embedding learning, spatial feature denoising and reconstruction, batch effect correction, and spatial domain optimization, effectively correcting batch effects and achieving accurate 3D spatial domain identification.
Jinyun Niu, Donghai Fang, Jinyu Chen, Yi Xiong, Juan Liu, Wenwen Min   +5 more
wiley   +1 more source

Expression of TRPM8 in the distal cerebrospinal fluid-contacting neurons in the brain mesencephalon of rats

Cerebrospinal Fluid Research, 2009
Background It has been shown that distal cerebrospinal fluid-contacting neurons (dCSF-CNs) exist near the ventral midline of the midbrain aqueduct and also in the grey matter of the inferior third ventricle and the fourth ventricle floor in the superior ...
Zhang Licai, Yang Xinwei, Du Jing, Zeng Yin-ming   +3 more
doaj   +1 more source

Synaptic Dysfunction in the Anterior Cingulate Cortex Underlies Pain‐Anxiety Comorbidity in a Mandibular Asymmetry Mouse Model

Advanced Science, EarlyView.
This study establishes a mandibular asymmetry (MA) mouse model that recapitulates chronic orofacial pain and anxiety comorbidity. Anterior cingulate cortex (ACC) hyperactivation and synaptic dysfunction are identified as central neural mechanisms underlying these pathologies, with chemogenetic inhibition of ACC CaMKII+ neurons effectively reversing ...
Zhaoyichun Zhang, Yanran Zhang, Jialin Si, Honghui Mao, Feng He, Jin Ning, Guaiguai Ma, Xiaohua Chen, Haoxiang Xiao, Yuanyuan Zhu, Haifeng Zhang, Yifan Lu, Qian Liu, Meng Nian, Shiquan Sun, Shibin Yu, Shengxi Wu, Ze Fan, Zuolin Jin, Jing Huang   +19 more
wiley   +1 more source

Fetal Porcine Dopaminergic Cell Survival in Vitro and its Relationship to Embryonic Age

Cell Transplantation, 1999
One of the critical factors in the survival of embryonic neural grafts is the age at which the population of donor neurons is harvested. This is especially the case for the developing dopaminergic neurons in the embryonic ventral mesencephalon, which are
Roger A. Barker, Emma Ratcliffe, Andrew Richards, Stephen B. Dunnett   +3 more
doaj   +1 more source

Treating Hearing Loss: From Cochlear Implantation to Gene Therapy

Advanced Science, EarlyView.
Cochlear implantation is the primary treatment for deafness, restoring functional hearing in over a million people. Recently, gene therapy has enabled biological hearing restoration in a small number of patients with OTOF‐related mutations. This perspective evaluates both approaches, concluding that cochlear implants will remain the standard for most ...
Fan‐Gang Zeng, Jieyu Qi, Chen‐Chi Wu, Yilai Shu, Renjie Chai   +4 more
wiley   +1 more source