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Cell Transplantation, 2011 Stem cells have two features: the ability to differentiate along different lineages and the ability of self-renewal. Two major types of stem cells have been described, namely, embryonic stem cells and adult stem cells. Embryonic stem cells (ESC) are obtained from the inner cell mass of the blastocyst and are associated with tumorigenesis, and the use ...
Dah-Ching Ding +2 more
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Human mesenchymal stem cells [PDF]
Cell Proliferation, 2021 AbstractMesenchymal stem cells (MSCs) have attracted great interest for cell therapy and tissue regeneration due to their self‐renewal capacity, multipotency and potent immunomodulatory effects on immune cells. However, heterogeneity of MSCs has become a prominent obstacle to limit their translation into practice, as cells from different tissue sources
Xiaoyong Chen +23 more
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Mesenchymal Stem/Stromal Cells Derived from Cervical Cancer Promote M2 Macrophage Polarization
Cells, 2023 Macrophages with the M2 phenotype promote tumor development through the immunosuppression of antitumor immunity. We previously demonstrated the presence of mesenchymal stem/stromal cells (MSCs) in cervical cancer (CeCa-MSCs), suggesting an immune ...
Víctor Adrián Cortés-Morales +10 more
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Inflammation and Regeneration, 2013 The multipotential progenitor cells called ,Mesenchymal Stem Cells" (MSC) are capable of differrentiation at least into bone, cartilage, and adipose tissues. The commonly recognized role of these cells is the formation of connective tissue which participates in formation of every organ.
Alun Wall, Tim Board
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Current Issues in Molecular Biology, 2022 Inside tumors, cancer cells display several mechanisms to create an immunosuppressive environment. On the other hand, by migration processes, mesenchymal stromal cells (MSCs) can be recruited by different cancer tumor types from tissues as distant as ...
Víctor M. Arenas-Luna +6 more
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European Journal of Histochemistry, 2022 Desmoplastic stroma (DS) and the epithelial-to-mesenchymal transition (EMT) play a key role in pancreatic ductal adenocarcinoma (PDAC) progression. To date, however, the combined expression of DS and EMT markers, and their association with variations in
Damián Sánchez-Ramírez +15 more
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The Beneficial Effects of Herbal Therapy (Zayesh Booalidaroo + Safoof-e Hefz + Royal Jelly) on Male Infertility [PDF]
Research in Molecular Medicine, 2023 Background: Several studies have recently been conducted on herbal plants due to their growing medicinal usage. Since it is estimated that male partner causes 40% of infertility, we aimed to examine the effects of herbal combinations, including Zayesh ...
Leila Naserpour +6 more
doaj
Journal of Immunology Research, 2020 Bone marrow mesenchymal stem/stromal cells (BM-MSCs) have immunoregulatory capacity; therefore, they have been used in different clinical protocols in which it is necessary to decrease the immune response.
Juan J. Montesinos +6 more
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Annals of Medicine, 2005 About 40 years ago Friedenstein described stromal cells in the bone marrow that were spindle shaped and proliferate to form colonies. These cells attach to plastic and are able to differentiate under defined in vitro conditions into multiple cell types present in many different tissues, e.g. osteoblasts, chondroblasts, adipocytes, etc.
Mark F Pittenger +4 more
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Caspases and p38 MAPK regulate endothelial cell adhesiveness for mesenchymal stem cells. [PDF]
PLoS ONE, 2013 Mesenchymal stem cells natively circulating or delivered into the blood stream home to sites of injury. The mechanism of mesenchymal stem cell homing to sites of injury is poorly understood.
Irina A Potapova +2 more
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