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Mesenchymal stem cells and their microenvironment
Stem Cell Research & Therapy, 2022 Mesenchymal stem cells (MSCs), coming from a wide range of sources, have multi-directional differentiation ability. MSCs play vital roles in immunomodulation, hematopoiesis and tissue repair.
Jiaxi Liu +6 more
semanticscholar +4 more sources
Human mesenchymal stem cells [PDF]
Cell Proliferation, 2021 Mesenchymal stem cells (MSCs) have attracted great interest for cell therapy and tissue regeneration due to their self‐renewal capacity, multipotency and potent immunomodulatory effects on immune cells.
Xiaoyong Chen +23 more
semanticscholar +3 more sources
Cell Transplantation, 2011 Stem cells have two features: the ability to differentiate along different lineages and the ability of self-renewal. Two major types of stem cells have been described, namely, embryonic stem cells and adult stem cells. Embryonic stem cells (ESC) are obtained from the inner cell mass of the blastocyst and are associated with tumorigenesis, and the use ...
Dah-Ching Ding +2 more
openaire +5 more sources
Mesenchymal Stem/Stromal Cells Derived from Cervical Cancer Promote M2 Macrophage Polarization
Cells, 2023 Macrophages with the M2 phenotype promote tumor development through the immunosuppression of antitumor immunity. We previously demonstrated the presence of mesenchymal stem/stromal cells (MSCs) in cervical cancer (CeCa-MSCs), suggesting an immune ...
Víctor Adrián Cortés-Morales +10 more
doaj +1 more source
Suicide-Gene Transfection of Tumor-tropic Placental Stem Cells employing Ultrasound-Responsive Nanoparticles [PDF]
Acta Biomaterialia. 83, 372-378 (2018), 2021 A Trojan-horse strategy for cancer therapy employing tumor-tropic mesenchymal stem cells transfected with a non-viral nanovector is here presented. In this sense, ultrasound-responsive mesoporous silica nanoparticles were coated with a polycation (using two different molecular weights), providing them with gene transfection capabilities that were ...
arxiv +1 more source
Current Issues in Molecular Biology, 2022 Inside tumors, cancer cells display several mechanisms to create an immunosuppressive environment. On the other hand, by migration processes, mesenchymal stromal cells (MSCs) can be recruited by different cancer tumor types from tissues as distant as ...
Víctor M. Arenas-Luna +6 more
doaj +1 more source
European Journal of Histochemistry, 2022 Desmoplastic stroma (DS) and the epithelial-to-mesenchymal transition (EMT) play a key role in pancreatic ductal adenocarcinoma (PDAC) progression. To date, however, the combined expression of DS and EMT markers, and their association with variations in
Damián Sánchez-Ramírez +15 more
doaj +1 more source
Low-intensity pulsed ultrasound promotes mesenchymal stem cell transplantation-based articular cartilage regeneration via inhibiting the TNF signaling pathway [PDF]
Stem Cell Res Ther 14, 93 (2023), 2021 Background: Mesenchymal stem cell (MSC) transplantation therapy is highly investigated for the regenerative repair of cartilage defects. Low-intensity pulsed ultrasound (LIPUS) has the potential to promote chondrogenic differentiation of MSCs. However, its underlying mechanism remains unclear.
arxiv +1 more source
Adipose Tissue-Derived Mesenchymal Stem Cells
Cells, 2021 The long-held belief about adipose tissue was that it was relatively inert in terms of biological activity. It was believed that its primary role was energy storage; however, that was shattered with the discovery of adipokines.
B. Bunnell
semanticscholar +1 more source
Mesenchymal Stem Cells for Neurological Disorders
Advancement of science, 2021 Neurological disorders are becoming a growing burden as society ages, and there is a compelling need to address this spiraling problem. Stem cell‐based regenerative medicine is becoming an increasingly attractive approach to designing therapies for such ...
A. Andrzejewska +3 more
semanticscholar +1 more source