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Cell Transplantation, 2011 Stem cells have two features: the ability to differentiate along different lineages and the ability of self-renewal. Two major types of stem cells have been described, namely, embryonic stem cells and adult stem cells. Embryonic stem cells (ESC) are obtained from the inner cell mass of the blastocyst and are associated with tumorigenesis, and the use ...
Dah-Ching Ding +2 more
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Mesenchymal Stem/Stromal Cells Derived from Cervical Cancer Promote M2 Macrophage Polarization
Cells, 2023 Macrophages with the M2 phenotype promote tumor development through the immunosuppression of antitumor immunity. We previously demonstrated the presence of mesenchymal stem/stromal cells (MSCs) in cervical cancer (CeCa-MSCs), suggesting an immune ...
Víctor Adrián Cortés-Morales +10 more
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Current Issues in Molecular Biology, 2022 Inside tumors, cancer cells display several mechanisms to create an immunosuppressive environment. On the other hand, by migration processes, mesenchymal stromal cells (MSCs) can be recruited by different cancer tumor types from tissues as distant as ...
Víctor M. Arenas-Luna +6 more
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European Journal of Histochemistry, 2022 Desmoplastic stroma (DS) and the epithelial-to-mesenchymal transition (EMT) play a key role in pancreatic ductal adenocarcinoma (PDAC) progression. To date, however, the combined expression of DS and EMT markers, and their association with variations in
Damián Sánchez-Ramírez +15 more
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The Beneficial Effects of Herbal Therapy (Zayesh Booalidaroo + Safoof-e Hefz + Royal Jelly) on Male Infertility [PDF]
Research in Molecular Medicine, 2023 Background: Several studies have recently been conducted on herbal plants due to their growing medicinal usage. Since it is estimated that male partner causes 40% of infertility, we aimed to examine the effects of herbal combinations, including Zayesh ...
Leila Naserpour +6 more
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Mesenchymal stem cells and their microenvironment
Stem Cell Research & Therapy, 2022 AbstractMesenchymal stem cells (MSCs), coming from a wide range of sources, have multi-directional differentiation ability. MSCs play vital roles in immunomodulation, hematopoiesis and tissue repair. The microenvironment of cells often refers to the intercellular matrix, other cells, cytokines and humoral components.
Jiaxi Liu +6 more
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Experimental Biology and Medicine, 2001 Within the bone marrow stroma there exists a subset of nonhematopoietic cells referred to as mesenchymal stem or mesenchymal progenitor cells. These cells can be ex vivo expanded and induced, either in vitro or in vivo, to terminally differentiate into osteoblasts, chondrocytes, adipocytes, tenocytes, myotubes, neural cells, and hematopoietic ...
Minguell, JJ, Erices, A, Conget, P
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Journal of Immunology Research, 2020 Bone marrow mesenchymal stem/stromal cells (BM-MSCs) have immunoregulatory capacity; therefore, they have been used in different clinical protocols in which it is necessary to decrease the immune response.
Juan J. Montesinos +6 more
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Immunobiology of mesenchymal stem cells [PDF]
Cell Death & Differentiation, 2013 Mesenchymal stem cells (MSCs) can be isolated from almost all tissues and effectively expanded in vitro. Although their true in situ properties and biological functions remain to be elucidated, these in vitro expanded cells have been shown to possess potential to differentiate into specific cell lineages.
Ying Wang +5 more
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Human mesenchymal stem cells [PDF]
Cell Proliferation, 2021 AbstractMesenchymal stem cells (MSCs) have attracted great interest for cell therapy and tissue regeneration due to their self‐renewal capacity, multipotency and potent immunomodulatory effects on immune cells. However, heterogeneity of MSCs has become a prominent obstacle to limit their translation into practice, as cells from different tissue sources
Xiaoyong Chen +23 more
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