Graphene for Controlled and Accelerated Osteogenic Differentiation of Human Mesenchymal Stem Cells [PDF]
ACS Nano 5, 4670-4678 (2011), 2011 Modern tissue engineering strategies combine living cells and scaffold materials to develop biological substitutes that can restore tissue functions. Both natural and synthetic materials have been fabricated for transplantation of stem cells and their ...
Ahn, Jong-Hyun +10 more
core +2 more sources
Alginate-encapsulated brain-derived neurotrophic factor–overexpressing mesenchymal stem cells are a promising drug delivery system for protection of auditory neurons [PDF]
Journal of Tissue Engineering, 2020 The cochlear implant outcome is possibly improved by brain-derived neurotrophic factor treatment protecting spiral ganglion neurons. Implantation of genetically modified mesenchymal stem cells may enable the required long-term brain-derived neurotrophic ...
Jana Schwieger +6 more
doaj +2 more sources
Suicide-Gene Transfection of Tumor-tropic Placental Stem Cells employing Ultrasound-Responsive Nanoparticles [PDF]
Acta Biomaterialia. 83, 372-378 (2018), 2021 A Trojan-horse strategy for cancer therapy employing tumor-tropic mesenchymal stem cells transfected with a non-viral nanovector is here presented. In this sense, ultrasound-responsive mesoporous silica nanoparticles were coated with a polycation (using two different molecular weights), providing them with gene transfection capabilities that were ...
arxiv +1 more source
Human Mesenchymal Stem Cells Overexpressing Interleukin 2 Can Suppress Proliferation of Neuroblastoma Cells in Co-Culture and Activate Mononuclear Cells In Vitro [PDF]
, 2020 High-dose recombinant interleukin 2 (IL2) therapy has been shown to be successful in renal cell carcinoma and metastatic melanoma. However, systemic administration of high doses of IL2 can be toxic, causing capillary leakage syndrome and stimulating pro ...
Akhmetzyanova, Elvira R. +9 more
core +2 more sources
Low-intensity pulsed ultrasound promotes mesenchymal stem cell transplantation-based articular cartilage regeneration via inhibiting the TNF signaling pathway [PDF]
Stem Cell Res Ther 14, 93 (2023), 2021 Background: Mesenchymal stem cell (MSC) transplantation therapy is highly investigated for the regenerative repair of cartilage defects. Low-intensity pulsed ultrasound (LIPUS) has the potential to promote chondrogenic differentiation of MSCs. However, its underlying mechanism remains unclear.
arxiv +1 more source
Investigation of the limits of nanoscale filopodial interactions [PDF]
, 2014 Mesenchymal stem cells are sensitive to changes in feature height, order and spacing. We had previously noted that there was an inverse relationship between osteoinductive potential and feature height on 15-, 55- and 90 nm-high titania nanopillars, with ...
Dalby, Matthew J. +5 more
core +5 more sources
Mesenchymal stem cells and JIA [PDF]
Pediatric Rheumatology, 2011 Background Mesenchymal stem cells (MSC) are adult stem cells present in bone marrow (BM), fat and in many other tissues. MSC have strong immunosuppressive qualities in vitro. The immunosuppression seems to work both by paracrine action and cell-cell contact. MSC inhibit NKcells, B-cells, dendritic cells, Th1-cells and activate regulatory T-cells.
W. Kuis +7 more
openaire +3 more sources
Influencing the secretion of myogenic factors from mesenchymal stem cells. [PDF]
, 2014 Mounting evidence indicates that the regenerative effect of mesenchymal stem cells in skeletal muscle is related to the secretion of factors that stimulate resident myogenic cells.
Smith, Lucas R
core +1 more source
Caspases and p38 MAPK regulate endothelial cell adhesiveness for mesenchymal stem cells. [PDF]
PLoS ONE, 2013 Mesenchymal stem cells natively circulating or delivered into the blood stream home to sites of injury. The mechanism of mesenchymal stem cell homing to sites of injury is poorly understood.
Irina A Potapova +2 more
doaj +1 more source
Mesenchymal stem cell-based therapy for ischemic stroke [PDF]
, 2016 Ischemic stroke represents a major, worldwide health burden with increasing incidence. Patients affected by ischemic strokes currently have few clinically approved treatment options available.
Anderson, JD +20 more
core +2 more sources