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The Concept of Mesenchymal Stem Cells
Regenerative Medicine, 2006In this chapter we examine whether criteria usually defining adult tissue stem cells apply to mesenchymal stem cells (MSCs) that give rise to cells of the skeletal connective tissues. MSCs appear to constitute a heterogeneous population of undifferentiated and committed, lineage-primed cells, capable of: homing upon engraftment to a number of growth ...
Bruno, Delorme +2 more
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Mesenchymal Stem Cells in Asthma
2019Asthma is one of the worldwide respiratory health problem that affect children and adult. Current treatment strategies such as conventional and allergen immunotherapy still fall behind. Mesenchymal stem cells (MSCs) have wide regenerative capacity and immunoregulatory activity with their wide range of secretions and contact dependent manner.
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Cryobanking Mesenchymal Stem Cells
2017Cryopreservation and storage of culture-expanded mesenchymal stem cells (MSCs) is essential for a biobank to maintain a collection of cell lines for research and clinical use. Optimization of cryopreservation protocols and methods to minimize damage to cells during freezing and thawing is critical to ensure reliable availability of viable cells ...
Andrés, Pavón +3 more
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Perivascular cells as mesenchymal stem cells
Expert Opinion on Biological Therapy, 2010Mesenchymal stem cells are multipotent adult stem cell populations that have broad differentiation plasticity and immunosuppressive potential that render them of great importance in cell-based therapies. They are identified by in vitro characteristics based on their differentiation potential for clinical approaches while their biological properties and
Feng, Jifan +2 more
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Mesenchymal Stem Cells in Cancer
Stem Cell Reviews, 2008It is becoming increasingly evident that stromal cells such as macrophages, mast cells, adipocytes and mesenchymal cells associated with tumors significantly contribute to tumorigenesis. Some types of cancer indeed profoundly rely on extrinsic signals afforded by infiltrating or neighbouring cells for survival, proliferation and dissemination.
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Mesenchymal Stem Cell Engineering
2018Mesenchymal stem cells (MSC) are multipotent stem cells that display the capacity to generate the tissue in which they reside. MSC have been used as progenitor cells to engineer cartilage implants that can be used to repair chondral and osteochondral lesions, or as trophic producers of bioactive factors to initiate endogenous regenerative activities in
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Mesenchymal Stem Cells and Hematopoietic Stem Cell Transplantation
Annals of the New York Academy of Sciences, 2003Abstract: Techniques have recently beome available to isolate and grow mesenchymal progenitors and to manipulate their growth under defined in vitro culture conditions. As a result mesenchymal stem cells can be rapidly expanded to numbers that are required for clinical application.
Willem E, Fibbe, Willy A, Noort
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MicroRNAs and Mesenchymal Stem Cells
2011In the adult body, mesenchymal stem cells (MSCs) represent a population with self-renewal ability and multipotent differentiation capabilities. The phenotype of these cells is modulated by a dynamic interplay of signals within a defined microenvironment.
Federica, Collino +4 more
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Mesenchymal Stem Cells: Promising for Myocardial Regeneration?
Current Stem Cell Research & Therapy, 2013The pandemic of cardiovascular disease is continuously expanding as the result of changing life styles and diets throughout the Old and New World. Immediate intervention therapy saves the lives of many patients after acute myocardial infarction (MI). However, for many this comes at the price of adverse cardiac remodeling and heart failure.
Przybyt, Ewa, Harmsen, Martin C.
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Mesenchymal stem cells in osteoarthritis
Current Opinion in Rheumatology, 2004Accumulating evidence indicates that every tissue contains stem cells. Our understanding of the biology of stem cells reveals that these cell populations have a critical role in the homeostasis and repair of tissues. Besides the local stem cell niches, additional compartments in the body such as the bone marrow may serve as reservoirs for stem cell ...
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