Results 31 to 40 of about 138,445 (169)

Immune niches orchestrated by intestinal mesenchymal stromal cells lining the crypt-villus

Frontiers in Immunology, 2022
The mammalian intestine is an organ that can be spatially defined by two axes: longitudinal and vertical. Such anatomical structure ensures the maintenance of a relatively immuno-quiescent and proliferation-promoting crypt for intestinal stem cell ...
Hongxiang Sun, Hongxiang Sun, Hongxiang Sun, Jianmei Tan, Jianmei Tan, Jianmei Tan, Hongqian Chen, Hongqian Chen, Hongqian Chen, Ningbo Wu, Ningbo Wu, Ningbo Wu, Bing Su, Bing Su, Bing Su, Bing Su, Bing Su   +16 more
doaj   +1 more source

Bone marrow mesenchymal stromal cells non-selectively protect chronic myeloid leukemia cells from imatinib-induced apoptosis via the CXCR4/CXCL12 axis

Haematologica, 2010
Background Residual chronic myeloid leukemia disease following imatinib treatment has been attributed to the presence of quiescent leukemic stem cells intrinsically resistant to imatinib.
Fabrizio Vianello, Federica Villanova, Veronica Tisato, Stefania Lymperi, Ka-Kei Ho, Ana R. Gomes, David Marin, Dominique Bonnet, Jane Apperley, Eric W.-F. Lam, Francesco Dazzi   +10 more
doaj   +1 more source

Mesenchymal Stromal Cells: New Directions [PDF]

Cell Stem Cell, 2012
Research into mesenchymal stromal/stem cells (MSCs) has been particularly exciting in the past five years. Our understanding of mechanisms of MSC-mediated tissue regeneration has undergone considerable evolution. Recent investigation of the primary in situ counterpart of cultured MSCs has led to fresh insights into MSC physiology and its role in the ...
openaire   +3 more sources

Aminobisphosphonates prevent the inhibitory effects exerted by lymph node stromal cells on anti-tumor Vδ 2 T lymphocytes in non-Hodgkin lymphomas

Haematologica, 2014
In this study, we analyzed the influence of mesenchymal stromal cells derived from lymph nodes of non-Hodgkin’s lymphomas, on effector functions and differentiation of Vdelta (δ)2 T lymphocytes.
Alessandra Musso, Silvia Catellani, Paolo Canevali, Sara Tavella, Roberta Venè, Silvia Boero, Ivana Pierri, Marco Gobbi, Annalisa Kunkl, Jean-Louis Ravetti, Maria Raffaella Zocchi, Alessandro Poggi   +11 more
doaj   +1 more source

Isolation of human bone marrow stromal cells from bone marrow biopsies for single-cell RNA sequencing

STAR Protocols, 2021
Summary: Bone marrow (BM) mesenchymal stromal cells play an important role in regulating stem cell quiescence and homeostasis; they are also key contributors to various hematological malignancies. However, human bone marrow stromal cells are difficult to
Hélène F.E. Gleitz, Inge A.M. Snoeren, Stijn N.R. Fuchs, Nils B. Leimkühler, Rebekka K. Schneider   +4 more
doaj   +1 more source

Oxygen tension plays a critical role in the hematopoietic microenvironment in vitro

Haematologica, 2012
Background In the bone marrow mesenchymal stromal cells and osteoblasts form functional niches for hematopoietic stem and progenitor cells. This microenvironment can be partially mimicked using in vitro co-culture systems.
Duohui Jing, Manja Wobus, David M. Poitz, Martin Bornhäuser, Gerhard Ehninger, Rainer Ordemann   +5 more
doaj   +1 more source

The cannabinoid receptor type 2 as mediator of mesenchymal stromal cell immunosuppressive properties. [PDF]

PLoS ONE, 2013
Mesenchymal stromal cells are non-hematopoietic, multipotent progenitor cells producing cytokines, chemokines, and extracellular matrix proteins that support hematopoietic stem cell survival and engraftment, influence immune effector cell development ...
Francesca Rossi, Maria Ester Bernardo, Giulia Bellini, Livio Luongo, Antonella Conforti, Iolanda Manzo, Francesca Guida, Luigia Cristino, Roberta Imperatore, Stefania Petrosino, Bruno Nobili, Vincenzo Di Marzo, Franco Locatelli, Sabatino Maione   +13 more
doaj   +1 more source

Mesenchymal stromal cells from pooled mononuclear cells of multiple bone marrow donors as rescue therapy in pediatric severe steroid-refractory graft-versus-host disease: a multicenter survey

Haematologica, 2016
To circumvent donor-to-donor heterogeneity which may lead to inconsistent results after treatment of acute graft-versus-host disease with mesenchymal stromal cells generated from single donors we developed a novel approach by generating these cells from ...
Zyrafete Kuçi, Halvard Bönig, Hermann Kreyenberg, Milica Bunos, Anna Jauch, Johannes W.G. Janssen, Marijana Škifić, Kristina Michel, Ben Eising, Giovanna Lucchini, Shahrzad Bakhtiar, Johann Greil, Peter Lang, Oliver Basu, Irene von Luettichau, Ansgar Schulz, Karl-Walter Sykora, Andrea Jarisch, Jan Soerensen, Emilia Salzmann-Manrique, Erhard Seifried, Thomas Klingebiel, Peter Bader, Selim Kuçi   +23 more
doaj   +1 more source

There is no transfer of mitochondria from donor hematopoietic cells to recipient mesenchymal stromal cells after allogeneic hematopoietic stem cells transplantation in humans

Hematology, Transfusion and Cell Therapy
Introduction: Multipotent mesenchymal stromal cells are progenitors of the bone marrow stromal microenvironment that support hematopoiesis. Mitochondria, which can be transferred between cells via nanotubes or extracellular vesicles, play a key role in ...
Natalya Sats, Vadim Surin, Tatiana Abramova, Aleksandra Sadovskaya, Nataliya Petinati, Nikolay Kapranov, Ksenia Nikiforova, Nina Drize, Luisa Karaseva, Olga Pokrovskaya, Larisa Kuzmina, Elena Parovichnikova   +11 more
doaj   +1 more source

Mesenchymal Stromal Cells for Transplant Tolerance [PDF]

Frontiers in Immunology, 2019
In solid organ transplantation lifelong immunosuppression exposes transplant recipients to life-threatening complications, such as infections and malignancies, and to severe side effects. Cellular therapy with mesenchymal stromal cells (MSC) has recently emerged as a promising strategy to regulate anti-donor immune responses, allowing immunosuppressive
Manuel Alfredo Podestà, Manuel Alfredo Podestà, Giuseppe Remuzzi, Federica Casiraghi   +3 more
openaire   +4 more sources