Results 1 to 10 of about 94,714 (283)

Age-associated changes in lineage composition of the enteric nervous system regulate gut health and disease

eLife, 2023
The enteric nervous system (ENS), a collection of neural cells contained in the wall of the gut, is of fundamental importance to gastrointestinal and systemic health.
Subhash Kulkarni, Monalee Saha, Jared Slosberg, Alpana Singh, Sushma Nagaraj, Laren Becker, Chengxiu Zhang, Alicia Bukowski, Zhuolun Wang, Guosheng Liu, Jenna M Leser, Mithra Kumar, Shriya Bakhshi, Matthew J Anderson, Mark Lewandoski, Elizabeth Vincent, Loyal A Goff, Pankaj Jay Pasricha   +17 more
doaj   +1 more source

Rapid Generation of Pulmonary Organoids from Induced Pluripotent Stem Cells by Co-Culturing Endodermal and Mesodermal Progenitors for Pulmonary Disease Modelling

Biomedicines, 2023
Differentiation of induced pluripotent stem cells to a range of target cell types is ubiquitous in monolayer culture. To further improve the phenotype of the cells produced, 3D organoid culture is becoming increasingly prevalent.
Adam Mitchell, Chaowen Yu, Xiangjun Zhao, Laurence Pearmain, Rajesh Shah, Karen Piper Hanley, Timothy Felton, Tao Wang   +7 more
doaj   +1 more source

Mature Mediastinal Teratoma [PDF]

Journal of Clinical and Diagnostic Research, 2015
A teratoma is a tumour with tissue or organ components resembling normal derivatives of more than one germ layer. We present a case of mediastinal mature teratoma as they have a low incidence rate.
Chikka Narasimhaiah Anushree, Vissa Shanti   +1 more
doaj   +1 more source

Evidence for a Role of the Lateral Ectoderm in Drosophila Mesoderm Invagination

Frontiers in Cell and Developmental Biology, 2022
The folding of two-dimensional epithelial sheets into specific three-dimensional structures is a fundamental tissue construction mechanism in animal development.
Hanqing Guo, Shicheng Huang, Bing He
doaj   +1 more source

Examining the Characteristics and Applications of Mesenchymal, Induced Pluripotent, and Embryonic Stem Cells for Tissue Engineering Approaches across the Germ Layers

Pharmaceuticals, 2020
The field of regenerative medicine utilizes a wide array of technologies and techniques for repairing and restoring function to damaged tissues. Among these, stem cells offer one of the most potent and promising biological tools to facilitate such goals.
Caitlin Priester, Amber MacDonald, Madhu Dhar, Austin Bow   +3 more
doaj   +1 more source

Therapeutic correction of hemophilia A by transplantation of hPSC-derived liver sinusoidal endothelial cell progenitors

Cell Reports, 2022
Summary: Liver sinusoidal endothelial cells (LSECs) form the predominant microvasculature in the liver where they carry out many functions including the secretion of coagulation factor VIII (FVIII).
Blair K. Gage, Simone Merlin, Cristina Olgasi, Antonia Follenzi, Gordon M. Keller   +4 more
doaj   +1 more source

Visceral organ morphogenesis via calcium-patterned muscle constrictions

eLife, 2022
Organ architecture is often composed of multiple laminar tissues arranged in concentric layers. During morphogenesis, the initial geometry of visceral organs undergoes a sequence of folding, adopting a complex shape that is vital for function.
Noah P Mitchell, Dillon J Cislo, Suraj Shankar, Yuzheng Lin, Boris I Shraiman, Sebastian J Streichan   +5 more
doaj   +1 more source

Distinct mesoderm migration phenotypes in extra-embryonic and embryonic regions of the early mouse embryo

eLife, 2019
In mouse embryo gastrulation, epiblast cells delaminate at the primitive streak to form mesoderm and definitive endoderm, through an epithelial-mesenchymal transition.
Bechara Saykali, Navrita Mathiah, Wallis Nahaboo, Marie-Lucie Racu, Latifa Hammou, Matthieu Defrance, Isabelle Migeotte   +6 more
doaj   +1 more source

Recognition of H2AK119ub plays an important role in RSF1-regulated early Xenopus development

Frontiers in Cell and Developmental Biology, 2023
Polycomb group (PcG) proteins are key regulators of gene expression and developmental programs via covalent modification of histones, but the factors that interpret histone modification marks to regulate embryogenesis are less studied.
Saeid Mohammad Parast, Deli Yu, Chunxu Chen, Chunxu Chen, Chunxu Chen, Amanda J. Dickinson, Chenbei Chang, Hengbin Wang, Hengbin Wang, Hengbin Wang   +9 more
doaj   +1 more source

Inhibition of IKK/NF-κB Signaling Enhances Differentiation of Mesenchymal Stromal Cells from Human Embryonic Stem Cells

Stem Cell Reports, 2016
Embryonic stem cell-derived mesenchymal stromal cells (MSCs; also known as mesenchymal stem cells) represent a promising source for bone regenerative medicine.
Peng Deng, Chenchen Zhou, Ruth Alvarez, Christine Hong, Cun-Yu Wang   +4 more
doaj   +1 more source