Results 1 to 10 of about 98,070 (189)

Inhibition of EZH2 Promotes Human Embryonic Stem Cell Differentiation into Mesoderm by Reducing H3K27me3 [PDF]

Stem Cell Reports, 2017
Mesoderm derived from human embryonic stem cells (hESCs) is a major source of the mesenchymal stem/stromal cells (MSCs) that can differentiate into osteoblasts and chondrocytes for tissue regeneration.
Yongxin Yu, Peng Deng, Bo Yu, John M. Szymanski, Tara Aghaloo, Christine Hong, Cun-Yu Wang   +6 more
doaj   +8 more sources

Brachyury co-operates with polycomb protein RYBP to regulate gastrulation and axial elongation in vitro [PDF]

Frontiers in Cell and Developmental Biology
Early embryonic development is a complex process where undifferentiated cells lose their pluripotency and start to gastrulate. During gastrulation, three germ layers form, giving rise to different cell lineages and organs.
Lilla Kokity, Lilla Kokity, Zsolt Czimmerer, Bernadett Benyhe-Kis, Bernadett Benyhe-Kis, Anna Poscher, Anna Poscher, Emese Belai, Emese Belai, Gábor Steinbach, Zoltan Lipinszki, Zoltan Lipinszki, Melinda Katalin Pirity   +12 more
doaj   +2 more sources

Age-associated changes in lineage composition of the enteric nervous system regulate gut health and disease

eLife, 2023
The enteric nervous system (ENS), a collection of neural cells contained in the wall of the gut, is of fundamental importance to gastrointestinal and systemic health.
Subhash Kulkarni, Monalee Saha, Jared Slosberg, Alpana Singh, Sushma Nagaraj, Laren Becker, Chengxiu Zhang, Alicia Bukowski, Zhuolun Wang, Guosheng Liu, Jenna M Leser, Mithra Kumar, Shriya Bakhshi, Matthew J Anderson, Mark Lewandoski, Elizabeth Vincent, Loyal A Goff, Pankaj Jay Pasricha   +17 more
doaj   +1 more source

Rapid Generation of Pulmonary Organoids from Induced Pluripotent Stem Cells by Co-Culturing Endodermal and Mesodermal Progenitors for Pulmonary Disease Modelling

Biomedicines, 2023
Differentiation of induced pluripotent stem cells to a range of target cell types is ubiquitous in monolayer culture. To further improve the phenotype of the cells produced, 3D organoid culture is becoming increasingly prevalent.
Adam Mitchell, Chaowen Yu, Xiangjun Zhao, Laurence Pearmain, Rajesh Shah, Karen Piper Hanley, Timothy Felton, Tao Wang   +7 more
doaj   +1 more source

Mature Mediastinal Teratoma [PDF]

Journal of Clinical and Diagnostic Research, 2015
A teratoma is a tumour with tissue or organ components resembling normal derivatives of more than one germ layer. We present a case of mediastinal mature teratoma as they have a low incidence rate.
Chikka Narasimhaiah Anushree, Vissa Shanti   +1 more
doaj   +1 more source

Visceral organ morphogenesis via calcium-patterned muscle constrictions

eLife, 2022
Organ architecture is often composed of multiple laminar tissues arranged in concentric layers. During morphogenesis, the initial geometry of visceral organs undergoes a sequence of folding, adopting a complex shape that is vital for function.
Noah P Mitchell, Dillon J Cislo, Suraj Shankar, Yuzheng Lin, Boris I Shraiman, Sebastian J Streichan   +5 more
doaj   +1 more source

Examining the Characteristics and Applications of Mesenchymal, Induced Pluripotent, and Embryonic Stem Cells for Tissue Engineering Approaches across the Germ Layers

Pharmaceuticals, 2020
The field of regenerative medicine utilizes a wide array of technologies and techniques for repairing and restoring function to damaged tissues. Among these, stem cells offer one of the most potent and promising biological tools to facilitate such goals.
Caitlin Priester, Amber MacDonald, Madhu Dhar, Austin Bow   +3 more
doaj   +1 more source

Insights from Amphioxus into the Evolution of Vertebrate Cartilage [PDF]

, 2007
Central to the story of vertebrate evolution is the origin of the vertebrate head, a problem difficult to approach using paleontology and comparative morphology due to a lack of unambiguous intermediate forms. Embryologically, much of the vertebrate head
A Beverdam, AJ Barlow, AK Wenke, AL Rychel, AL Rychel, C Gans, C Tribioli, CA Ettensohn, CA Yoshida, CT Miller, CT Miller, CV Baker, D Meulemans, D Meulemans, D Meulemans, D ten Berge, Daniel Meulemans, DM Bell, DW McCauley, FS Jones, G Amore, G Zhang, GF Couly, GJ Zhang, H Rahr, H Wada, I Rodrigo, J Azariah, J Mallatt, J Walshe, J Wilson, Jean-Nicolas Volff, JK Yu, JR Martinez-Morales, JR Stone, JS Kang, K Soo, K Yasui, LA Lettice, M Cheung, Marianne Bronner-Fraser, MD Stokes, MV Flores, ND Hopwood, P Smits, Q Zhao, R Meech, RF Spokony, RG Northcutt, S Bruneau, S Perez-Alcala, SA Tahtakran, SH Settle, V Lefebvre, V Lefebvre, WR Jeffery, YL Yan, YL Yan   +57 more
core   +16 more sources

Early patterning and specification of cardiac progenitors in gastrulating mesoderm

eLife, 2014
Mammalian heart development requires precise allocation of cardiac progenitors. The existence of a multipotent progenitor for all anatomic and cellular components of the heart has been predicted but its identity and contribution to the two cardiac ...
W Patrick Devine, Joshua D Wythe, Matthew George, Kazuko Koshiba-Takeuchi, Benoit G Bruneau   +4 more
doaj   +1 more source

Homology of the cranial vault in birds: new insights based on embryonic fate-mapping and character analysis [PDF]

Royal Society Open Science, 2016
Bones of the cranial vault appear to be highly conserved among tetrapod vertebrates. Moreover, bones identified with the same name are assumed to be evolutionarily homologous. However, recent developmental studies reveal a key difference in the embryonic
Hillary C. Maddin, Nadine Piekarski, Elizabeth M. Sefton, James Hanken   +3 more
doaj   +1 more source