Results 31 to 40 of about 52,080 (250)

Homology of the cranial vault in birds: new insights based on embryonic fate-mapping and character analysis [PDF]

open access: yesRoyal Society Open Science, 2016
Bones of the cranial vault appear to be highly conserved among tetrapod vertebrates. Moreover, bones identified with the same name are assumed to be evolutionarily homologous. However, recent developmental studies reveal a key difference in the embryonic
Hillary C. Maddin   +3 more
doaj   +1 more source

Cardiac differentiation of human pluripotent stem cells using defined extracellular matrix proteins reveals essential role of fibronectin

open access: yeseLife, 2022
Research and therapeutic applications using human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) require robust differentiation strategies. Efforts to improve hPSC-CM differentiation have largely overlooked the role of extracellular matrix (ECM).
Jianhua Zhang   +9 more
doaj   +1 more source

Inverse agonism of retinoic acid receptors directs epiblast cells into the paraxial mesoderm lineage

open access: yesStem Cell Research, 2018
We have investigated the differentiation of paraxial mesoderm from mouse embryonic stem cells utilizing a Tbx6-EYFP/Brachyury (T)-Cherry dual reporter system.
Ryan P. Russell   +3 more
doaj   +1 more source

Targeted Disruption of TCF12 Reveals HEB as Essential in Human Mesodermal Specification and Hematopoiesis

open access: yesStem Cell Reports, 2017
Hematopoietic stem cells arise from mesoderm-derived hemogenic endothelium (HE) during embryogenesis in a process termed endothelial-hematopoietic transition (EHT).
Yang Li   +6 more
doaj   +1 more source

mNanog possesses dorsal mesoderm-inducing ability by modulating both BMP and Activin/nodal signaling in Xenopus ectodermal cells. [PDF]

open access: yesPLoS ONE, 2012
BACKGROUND:In Xenopus early embryogenesis, various genes are involved with mesoderm formation. In particular, dorsal mesoderm contains the organizer region and induces neural tissues through the inhibition of bone morphogenetic protein (BMP) signaling ...
Aya Miyazaki   +8 more
doaj   +1 more source

The Origin of Mesoderm in Phoronids

open access: yesDevelopmental Biology, 2002
Descriptive studies of phoronid development have concluded that the mesoderm of these animals originates from the endoderm during gastrulation. This interpretation has been tested by labeling one blastomere of 4- through 16-cell embryos and examining the position and germ layers occupied by the labeled clones of cells in the larva. No 2 injections gave
Freeman, Gary, Martindale, Mark Q.
openaire   +2 more sources

New Insights Into Cranial Synchondrosis Development: A Mini Review

open access: yesFrontiers in Cell and Developmental Biology, 2020
The synchondroses formed via endochondral ossification in the cranial base are an important growth center for the neurocranium. Abnormalities in the synchondroses affect cranial base elongation and the development of adjacent regions, including the ...
Noriko Funato, Noriko Funato
doaj   +1 more source

Rab7 is required for mesoderm patterning and gastrulation in Xenopus

open access: yesBiology Open, 2021
Early embryogenesis requires tightly controlled temporal and spatial coordination of cellular behavior and signaling. Modulations are achieved at multiple levels, from cellular transcription to tissue-scale behavior.
Jennifer Kreis   +2 more
doaj   +1 more source

Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis

open access: yesHepatology, EarlyView., 2022
Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog   +12 more
wiley   +1 more source

Early markers of induced pluripotent stem cell hematopoietic development

open access: yesМедицинская иммунология
The generation of immune cell populations from induced pluripotent stem cells (iPSCs) is a valuable model to study mechanisms that control hematopoietic development; it also is a promising approach to develop immunotherapeutic strategies to treat various
O. N. Sheveleva   +2 more
doaj   +1 more source

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