Inhibition of EZH2 Promotes Human Embryonic Stem Cell Differentiation into Mesoderm by Reducing H3K27me3 [PDF]
Stem Cell Reports, 2017 Mesoderm derived from human embryonic stem cells (hESCs) is a major source of the mesenchymal stem/stromal cells (MSCs) that can differentiate into osteoblasts and chondrocytes for tissue regeneration.
Yongxin Yu +6 more
doaj +4 more sources
A system to enrich for primitive streak-derivatives, definitive endoderm and mesoderm, from pluripotent cells in culture [PDF]
, 2012 Two lineages of endoderm develop during mammalian embryogenesis, the primitive endoderm in the pre-implantation blastocyst and the definitive endoderm at gastrulation.
Familari, M. +6 more
core +15 more sources
Hox Genes Regulate Muscle Founder Cell Pattern Autonomously and Regulate Morphogenesis Through Motor Neurons [PDF]
, 2010 The differentiation of myoblasts to form functional muscle fibers is a consequence of interactions between the mesoderm and ectoderm. The authors examine the role of segment identity in directing these interactions by studying the role of Hox genes in ...
Dutta, Devkanya +4 more
core +1 more source
The occipital lateral plate mesoderm is a novel source for vertebrate neck musculature [PDF]
, 2010 In vertebrates, body musculature originates from somites, whereas head muscles originate from the cranial mesoderm. Neck muscles are located in the transition between these regions.
Christ, B. +9 more
core +1 more source
Cell Reports, 2020 Summary: Attempts to generate functional blood cells from human pluripotent stem cells (hPSCs) remain largely unsuccessful, mainly due to the lack of understanding of the regulatory network of human hematopoiesis.
Yu Wang +13 more
doaj +1 more source
Quantitative imaging of the collective cell movements shaping an embryo [PDF]
, 2009 The recent development of imaging and image processing techniques, such as 4D microscopy and 3D cell tracking, enables analysis through quantification of the movement of large cell populations in vivo.
Fraser, Scott E. +3 more
core +1 more source
Functionally distinct roles for T and Tbx6 during mouse development
Biology Open, 2020 The mouse T-box transcription factors T and Tbx6 are co-expressed in the primitive streak and have unique domains of expression; T is expressed in the notochord, while Tbx6 is expressed in the presomitic mesoderm.
Amy K. Wehn +4 more
doaj +1 more source
Gene regulatory network subcircuit controlling a dynamic spatial pattern of signaling in the sea urchin embryo [PDF]
, 2008 We dissect the transcriptional regulatory relationships coordinating the dynamic expression patterns of two signaling genes, wnt8 and delta, which are central to specification of the sea urchin embryo endomesoderm.
Alifragis +34 more
core +3 more sources
Fibroepithelial Polyp Originating from the Nasal Septum
Turkish Archives of Otorhinolaryngology, 2019 Fibroepithelial polyp (FEP) is a rare clinical condition of mesodermal origin, covered usually by squamous epithelium, originating most frequently from the skin, genitourinary and lower respiratory tract.
Marko Stoiljkov, Aleksandar Perić
doaj +1 more source
Early patterning and specification of cardiac progenitors in gastrulating mesoderm
eLife, 2014 Mammalian heart development requires precise allocation of cardiac progenitors. The existence of a multipotent progenitor for all anatomic and cellular components of the heart has been predicted but its identity and contribution to the two cardiac ...
W Patrick Devine +4 more
doaj +1 more source