Results 21 to 30 of about 94,714 (283)

Cohesin Components Stag1 and Stag2 Differentially Influence Haematopoietic Mesoderm Development in Zebrafish Embryos

Frontiers in Cell and Developmental Biology, 2020
Cohesin is a multiprotein complex made up of core subunits Smc1, Smc3, and Rad21, and either Stag1 or Stag2. Normal haematopoietic development relies on crucial functions of cohesin in cell division and regulation of gene expression via three-dimensional
Sarada Ketharnathan, Anastasia Labudina, Julia A. Horsfield, Julia A. Horsfield   +3 more
doaj   +1 more source

The early stages of heart development: insights from chicken embryos [PDF]

, 2016
The heart is the first functioning organ in the developing embryo and the detailed understanding of the molecular and cellular mechanisms involved in its formation provides insights into congenital malformations affecting its function and therefore the ...
Alsan, Arguello, de la Cruz, de La Cruz, de la Cruz, DeHaan, Hatada, Kitajima, Le Lievre, Needham, Plein, Psychoyos, Rosenquist, Schultheiss, Stern, Tam, Vincent, Waldo, Yatskievych, Zhang   +19 more
core   +2 more sources

Gene profiling of head mesoderm in early zebrafish development: insights into the evolution of cranial mesoderm

EvoDevo, 2019
Background The evolution of the head was one of the key events that marked the transition from invertebrates to vertebrates. With the emergence of structures such as eyes and jaws, vertebrates evolved an active and predatory life style and radiated into ...
Huijia Wang, Peter W. H. Holland, Tokiharu Takahashi   +2 more
doaj   +1 more source

Homology of the cranial vault in birds: new insights based on embryonic fate-mapping and character analysis [PDF]

Royal Society Open Science, 2016
Bones of the cranial vault appear to be highly conserved among tetrapod vertebrates. Moreover, bones identified with the same name are assumed to be evolutionarily homologous. However, recent developmental studies reveal a key difference in the embryonic
Hillary C. Maddin, Nadine Piekarski, Elizabeth M. Sefton, James Hanken   +3 more
doaj   +1 more source

Cardiac differentiation of human pluripotent stem cells using defined extracellular matrix proteins reveals essential role of fibronectin

eLife, 2022
Research and therapeutic applications using human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) require robust differentiation strategies. Efforts to improve hPSC-CM differentiation have largely overlooked the role of extracellular matrix (ECM).
Jianhua Zhang, Zachery R Gregorich, Ran Tao, Gina C Kim, Pratik A Lalit, Juliana L Carvalho, Yogananda Markandeya, Deane F Mosher, Sean P Palecek, Timothy J Kamp   +9 more
doaj   +1 more source

Generation of an expandable intermediate mesoderm restricted progenitor cell line from human pluripotent stem cells. [PDF]

, 2015
The field of tissue engineering entered a new era with the development of human pluripotent stem cells (hPSCs), which are capable of unlimited expansion whilst retaining the potential to differentiate into all mature cell populations.
Brafman, David, Bush, Kevin T, Cutts, Josh, Gaasterland, Terry, Kumar, Nathan, Nigam, Sanjay K, Richter, Jenna, Trujillo, Cleber, Willert, Karl   +8 more
core   +3 more sources

Inverse agonism of retinoic acid receptors directs epiblast cells into the paraxial mesoderm lineage

Stem Cell Research, 2018
We have investigated the differentiation of paraxial mesoderm from mouse embryonic stem cells utilizing a Tbx6-EYFP/Brachyury (T)-Cherry dual reporter system.
Ryan P. Russell, Yu Fu, Yaling Liu, Peter Maye   +3 more
doaj   +1 more source

mNanog possesses dorsal mesoderm-inducing ability by modulating both BMP and Activin/nodal signaling in Xenopus ectodermal cells. [PDF]

PLoS ONE, 2012
BACKGROUND:In Xenopus early embryogenesis, various genes are involved with mesoderm formation. In particular, dorsal mesoderm contains the organizer region and induces neural tissues through the inhibition of bone morphogenetic protein (BMP) signaling ...
Aya Miyazaki, Kentaro Ishii, Satoshi Yamashita, Susumu Nejigane, Shinya Matsukawa, Yuzuru Ito, Yasuko Onuma, Makoto Asashima, Tatsuo Michiue   +8 more
doaj   +1 more source

Targeted Disruption of TCF12 Reveals HEB as Essential in Human Mesodermal Specification and Hematopoiesis

Stem Cell Reports, 2017
Hematopoietic stem cells arise from mesoderm-derived hemogenic endothelium (HE) during embryogenesis in a process termed endothelial-hematopoietic transition (EHT).
Yang Li, Patrick M. Brauer, Jastaranpreet Singh, Sintia Xhiku, Kogulan Yoganathan, Juan Carlos Zúñiga-Pflücker, Michele K. Anderson   +6 more
doaj   +1 more source

Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis

Hepatology, EarlyView., 2022
Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog, Reika Fujiwara, Stephanie Q. Pan, Khairat B. El‐Baradie, Hye Yeon Choi, Sonal Sinha, Qihong Yang, Kinji Asahina, Yibu Chen, Meng Li, Matthew Salomon, Stanley W.‐K. Ng, Hidekazu Tsukamoto   +12 more
wiley   +1 more source