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Genetic-Metabolic Coupling for Targeted Metabolic Engineering [PDF]
Cell Reports, 2017 Summary: Production of chemicals in microbes often employs potent biosynthetic enzymes, which can interact with the microbial native metabolism to affect cell fitness and product yield.
Stefano Cardinale +2 more
doaj +10 more sources
Advances in the optimization of central carbon metabolism in metabolic engineering
Microbial Cell Factories, 2023 Central carbon metabolism (CCM), including glycolysis, tricarboxylic acid cycle and the pentose phosphate pathway, is the most fundamental metabolic process in the activities of living organisms that maintains normal cellular growth.
Zhenke Wu +7 more
doaj +2 more sources
Analytics for metabolic engineering [PDF]
Frontiers in Bioengineering and Biotechnology, 2015 Realizing the promise of metabolic engineering has been slowed by challenges related to moving beyond proof-of-concept examples to robust and economically viable systems. Key to advancing metabolic engineering beyond trial-and-error research is access to
Christopher J Petzold +4 more
doaj +4 more sources
Metabolic network modularity arising from simple growth processes [PDF]
Phys. Rev. E 86, 036107 (2012), 2012 Metabolic networks consist of linked functional components, or modules. The mechanism underlying metabolic network modularity is of great interest not only to researchers of basic science but also to those in fields of engineering. Previous studies have suggested a theoretical model, which proposes that a change in the evolutionary goal (system ...
Takemoto, Kazuhiro
arxiv +3 more sources
Reconstruction of metabolic networks from high-throughput metabolite profiling data: in silico analysis of red blood cell metabolism [PDF]
Ann. N.Y. Acad. Sci. 1115: 102\^a?"115 (2007), 2007 We investigate the ability of algorithms developed for reverse engineering of transcriptional regulatory networks to reconstruct metabolic networks from high-throughput metabolite profiling data. For this, we generate synthetic metabolic profiles for benchmarking purposes based on a well-established model for red blood cell metabolism.
Barbagallo M. +18 more
arxiv +3 more sources
Applied Microbiology and Biotechnology, 2001 Metabolic engineering has developed as a very powerful approach to optimising industrial fermentation processes through the introduction of directed genetic changes using recombinant DNA technology. Successful metabolic engineering starts with a careful analysis of cellular function; based on the results of this analysis, an improved strain is designed
中村 憲夫 +3 more
openaire +4 more sources
Plant Metabolic Engineering [PDF]
Plant Physiology, 2001 Metabolic engineering is generally defined as the redirection of one or more enzymatic reactions to produce new compounds in an organism, improve the production of existing compounds, or mediate the degradation of compounds.
Dean DellaPenna
openalex +4 more sources
Auxin-mediated protein depletion for metabolic engineering in terpene-producing yeast
Nature Communications, 2021 Loss-of-function experiments are used in metabolic engineering to understand and optimise metabolism. Here, the authors apply auxin inducible protein degradation to test different metabolic engineering strategies for improved terpenoid production in ...
Zeyu Lu +4 more
doaj +2 more sources
Integrative metabolic engineering
AIMS Bioengineering, 2015 Recent advances in experimental and computational synthetic biology are extremely useful for achieving metabolic engineering objectives. The integration of synthetic biology and metabolic engineering within an iterative design-build-test framework will ...
George H McArthur IV +3 more
doaj +3 more sources
METABOLIC ENGINEERING OF SOLVENTOGENIC Clostridia [PDF]
Biotechnologia Acta, 2019 Literary data on the organization of the genome, the connection of genes with the production and regulation of solvents, and the metabolic engineering of solventogenic clostridia are presented.
O. Tigunova +3 more
doaj +3 more sources