Results 1 to 10 of about 564,369 (192)

Genetic-Metabolic Coupling for Targeted Metabolic Engineering [PDF]

Cell Reports, 2017
Summary: Production of chemicals in microbes often employs potent biosynthetic enzymes, which can interact with the microbial native metabolism to affect cell fitness and product yield.
Stefano Cardinale, Felipe Gonzalo Tueros, Morten Otto Alexander Sommer   +2 more
doaj   +4 more sources

Synthetic RNA Silencing of Actinorhodin Biosynthesis in Streptomyces coelicolor A3(2) [PDF]

, 2013
We demonstrate the first application of synthetic RNA gene silencers in Streptomyces coelicolor A3(2). Peptide nucleic acid and expressed antisense RNA silencers successfully inhibited actinorhodin production.
A Hesketh, Andrew Hesketh, CG Hebert, D D'alia, E Wagner, F Flett, Gabriel C. Uguru, GC Uguru, H Aiba, IL Hofacker, J Livny, J Livny, J Pánek, James E. M. Stach, JP Swiercz, L Good, L Good, Liam Good, LS Waters, M McArthur, M McArthur, Madhav Mondhe, Mark Isalan, Mervyn J. Bibb, MP Vockenhuber, MP Vockenhuber, MW Pfaffl, N Nakashima, N Nekhotiaeva, N Shen, NM Romero, NM Romero, P Hindra, R Dryselius, RP Desai, S Goh, S Herai, SG Kang, Shan Goh, T Morita, T Tezuka, TA Hjalt, W Minas, Y Chen   +43 more
core   +5 more sources

METABOLIC ENGINEERING OF SOLVENTOGENIC Clostridia [PDF]

Biotechnologia Acta, 2019
Literary data on the organization of the genome, the connection of genes with the production and regulation of solvents, and the metabolic engineering of solventogenic clostridia are presented.
O. Tigunova, N. Beyko, G. Andriiash, S. Shulga   +3 more
doaj   +1 more source

Integrative metabolic engineering

AIMS Bioengineering, 2015
Recent advances in experimental and computational synthetic biology are extremely useful for achieving metabolic engineering objectives. The integration of synthetic biology and metabolic engineering within an iterative design-build-test framework will ...
George H McArthur IV, Pooja P Nanjannavar, Emily H Miller, Stephen S Fong   +3 more
doaj   +1 more source

Considering Strain Variation and Non-Type Strains for Yeast Metabolic Engineering Applications

Life, 2022
A variety of yeast species have been considered ideal hosts for metabolic engineering to produce value-added chemicals, including the model organism Saccharomyces cerevisiae, as well as non-conventional yeasts including Yarrowia lipolytica, Kluyveromyces
Xiunan Yi, Hal S. Alper
doaj   +1 more source

Metabolic engineering of micronutrients in crop plants [PDF]

, 2016
Micronutrient deficiency is a widespread phenomenon, most prevalent in developing countries. Being causally linked to the occurrence of a range of diseases, it affects billions of people worldwide. Enhancing the content of micronutrients in crop products
Blancquaert, Dieter, De Steur, Hans, Gellynck, Xavier, Van Der Straeten, Dominique   +3 more
core   +2 more sources

Genomic and proteomic biases inform metabolic engineering strategies for anaerobic fungi. [PDF]

, 2020
Anaerobic fungi (Neocallimastigomycota) are emerging non-model hosts for biotechnology due to their wealth of biomass-degrading enzymes, yet tools to engineer these fungi have not yet been established.
Albà, Arazoe, Atasoglu, Bach, Beckham, Bezanson, Birdsell, Boch, Bonugli-Santos, Brownlee, Calkins, Camacho, Camiolo, Carlson, Chan, Chen, Cheng, Cheng, Chokhawala, Coker, Deshpande, Diener, Dollhofer, Duarte, Durand, Duret, Fondon, Galtier, Gasiunas, Gentzsch, Gerngross, Glass, Glémin, Greene, Grigoriev, Haitjema, Haitjema, Hamilton, Hanafy, Hartfield, Henske, Hershberg, Hildebrand, Hull, Jiang, Karlin, Kiktev, Kleinstiver, Kleinstiver, Knauer, Knight, Kuyper, Leberer, Li, Liggenstoffer, Liu, Magee, Mertens, Meunier, Morrison, Murphy, Nicholson, Nieuwenhuis, Nørholm, Orpin, Oyola, O’Malley, Podolsky, Raymond, Reichenberger, Ropars, Sadhu, Sammond, Sekowska, Seppälä, Seppälä, Solieri, Solomon, Sonan, Staben, Steensels, Steensels, Sukumaran, Theodorou, UniProt: a worldwide hub of protein knowledge, Videvall, Wang, Wang, Wright, Wu, Ximenes, Youssef, Zetsche   +92 more
core   +1 more source

Analytics for metabolic engineering

Frontiers in Bioengineering and Biotechnology, 2015
Realizing the promise of metabolic engineering has been slowed by challenges related to moving beyond proof-of-concept examples to robust and economically viable systems. Key to advancing metabolic engineering beyond trial-and-error research is access to
Christopher J Petzold, Leanne Jade G Chan, Melissa eNhan, Paul D Adams, Paul D Adams   +4 more
doaj   +1 more source

Microbial cell factories based on filamentous bacteria, yeasts, and fungi

Microbial Cell Factories, 2023
Background Advanced DNA synthesis, biosensor assembly, and genetic circuit development in synthetic biology and metabolic engineering have reinforced the application of filamentous bacteria, yeasts, and fungi as promising chassis cells for chemical ...
Qiang Ding, Chao Ye
doaj   +1 more source

Gene-to-metabolite network for biosynthesis of lignans in MeJA-elicited Isatis indigotica hairy root cultures. [PDF]

, 2015
Root and leaf tissue of Isatis indigotica shows notable anti-viral efficacy, and are widely used as "Banlangen" and "Daqingye" in traditional Chinese medicine.
Chen, Junfeng, Chen, Ruibing, Chen, Wansheng, Gao, Shouhong, Li, Qing, Ma, Ruifang, Tan, Hexin, Xiao, Ying, Zerbe, Philipp, Zhang, Lei   +9 more
core   +2 more sources