Results 11 to 20 of about 574,220 (331)

Metabolic engineering of sesquiterpene metabolism in yeast [PDF]

Biotechnology and Bioengineering, 2006
AbstractTerpenes are structurally diverse compounds that are of interest because of their biological activities and industrial value. These compounds consist of chirally rich hydrocarbon backbones derived from terpene synthases, which are subsequently decorated with hydroxyl substituents catalyzed by terpene hydroxylases.
Shunji Takahashi, Bryan T. Greenhagen, Joseph P. Noel, Yunsoo Yeo, Tom McMullin, Linsheng Song, Reinhardt A. Rosson, Joseph Chappell, Julie Maurina-Brunker   +8 more
openaire   +3 more sources

Synthetic RNA Silencing of Actinorhodin Biosynthesis in Streptomyces coelicolor A3(2) [PDF]

, 2013
We demonstrate the first application of synthetic RNA gene silencers in Streptomyces coelicolor A3(2). Peptide nucleic acid and expressed antisense RNA silencers successfully inhibited actinorhodin production.
A Hesketh, Andrew Hesketh, CG Hebert, D D'alia, E Wagner, F Flett, Gabriel C. Uguru, GC Uguru, H Aiba, IL Hofacker, J Livny, J Livny, J Pánek, James E. M. Stach, JP Swiercz, L Good, L Good, Liam Good, LS Waters, M McArthur, M McArthur, Madhav Mondhe, Mark Isalan, Mervyn J. Bibb, MP Vockenhuber, MP Vockenhuber, MW Pfaffl, N Nakashima, N Nekhotiaeva, N Shen, NM Romero, NM Romero, P Hindra, R Dryselius, RP Desai, S Goh, S Herai, SG Kang, Shan Goh, T Morita, T Tezuka, TA Hjalt, W Minas, Y Chen   +43 more
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Microbial cell factories based on filamentous bacteria, yeasts, and fungi

Microbial Cell Factories, 2023
Background Advanced DNA synthesis, biosensor assembly, and genetic circuit development in synthetic biology and metabolic engineering have reinforced the application of filamentous bacteria, yeasts, and fungi as promising chassis cells for chemical ...
Qiang Ding, Chao Ye
doaj   +1 more source

Genomic and proteomic biases inform metabolic engineering strategies for anaerobic fungi. [PDF]

, 2020
Anaerobic fungi (Neocallimastigomycota) are emerging non-model hosts for biotechnology due to their wealth of biomass-degrading enzymes, yet tools to engineer these fungi have not yet been established.
Albà, Arazoe, Atasoglu, Bach, Beckham, Bezanson, Birdsell, Boch, Bonugli-Santos, Brownlee, Calkins, Camacho, Camiolo, Carlson, Chan, Chen, Cheng, Cheng, Chokhawala, Coker, Deshpande, Diener, Dollhofer, Duarte, Durand, Duret, Fondon, Galtier, Gasiunas, Gentzsch, Gerngross, Glass, Glémin, Greene, Grigoriev, Haitjema, Haitjema, Hamilton, Hanafy, Hartfield, Henske, Hershberg, Hildebrand, Hull, Jiang, Karlin, Kiktev, Kleinstiver, Kleinstiver, Knauer, Knight, Kuyper, Leberer, Li, Liggenstoffer, Liu, Magee, Mertens, Meunier, Morrison, Murphy, Nicholson, Nieuwenhuis, Nørholm, Orpin, Oyola, O’Malley, Podolsky, Raymond, Reichenberger, Ropars, Sadhu, Sammond, Sekowska, Seppälä, Seppälä, Solieri, Solomon, Sonan, Staben, Steensels, Steensels, Sukumaran, Theodorou, UniProt: a worldwide hub of protein knowledge, Videvall, Wang, Wang, Wright, Wu, Ximenes, Youssef, Zetsche   +92 more
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Considering Strain Variation and Non-Type Strains for Yeast Metabolic Engineering Applications

Life, 2022
A variety of yeast species have been considered ideal hosts for metabolic engineering to produce value-added chemicals, including the model organism Saccharomyces cerevisiae, as well as non-conventional yeasts including Yarrowia lipolytica, Kluyveromyces
Xiunan Yi, Hal S. Alper
doaj   +1 more source

The virus as metabolic engineer [PDF]

Biotechnology Journal, 2010
AbstractRecent genome‐wide screens of host genetic requirements for viral infection have reemphasized the critical role of host metabolism in enabling the production of viral particles. In this review, we highlight the metabolic aspects of viral infection found in these studies, and focus on the opportunities these requirements present for metabolic ...
Miriam V. Gutschow, Nathaniel D. Maynard, Markus W. Covert, Elsa W. Birch   +3 more
openaire   +3 more sources

Metabolic engineering of micronutrients in crop plants [PDF]

, 2016
Micronutrient deficiency is a widespread phenomenon, most prevalent in developing countries. Being causally linked to the occurrence of a range of diseases, it affects billions of people worldwide. Enhancing the content of micronutrients in crop products
Blancquaert, Dieter, De Steur, Hans, Gellynck, Xavier, Van Der Straeten, Dominique   +3 more
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Gene-to-metabolite network for biosynthesis of lignans in MeJA-elicited Isatis indigotica hairy root cultures. [PDF]

, 2015
Root and leaf tissue of Isatis indigotica shows notable anti-viral efficacy, and are widely used as "Banlangen" and "Daqingye" in traditional Chinese medicine.
Chen, Junfeng, Chen, Ruibing, Chen, Wansheng, Gao, Shouhong, Li, Qing, Ma, Ruifang, Tan, Hexin, Xiao, Ying, Zerbe, Philipp, Zhang, Lei   +9 more
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Advances in the optimization of central carbon metabolism in metabolic engineering

Microbial Cell Factories, 2023
Central carbon metabolism (CCM), including glycolysis, tricarboxylic acid cycle and the pentose phosphate pathway, is the most fundamental metabolic process in the activities of living organisms that maintains normal cellular growth.
Zhenke Wu, Xiqin Liang, Mingkai Li, Mengyu Ma, Qiusheng Zheng, Defang Li, Tianyue An, Guoli Wang   +7 more
doaj   +1 more source

Metabolic Engineering of Bacteria [PDF]

Indian Journal of Microbiology, 2011
Yield and productivity are critical for the economics and viability of a bioprocess. In metabolic engineering the main objective is the increase of a target metabolite production through genetic engineering. Metabolic engineering is the practice of optimizing genetic and regulatory processes within cells to increase the production of a certain ...
Ravi Ranjan Kumar, Satish Prasad
openaire   +3 more sources