Results 11 to 20 of about 290,662 (155)
Advances in the optimization of central carbon metabolism in metabolic engineering
Microbial Cell Factories, 2023 Central carbon metabolism (CCM), including glycolysis, tricarboxylic acid cycle and the pentose phosphate pathway, is the most fundamental metabolic process in the activities of living organisms that maintains normal cellular growth.
Zhenke Wu +7 more
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Characterizing and engineering promoters for metabolic engineering of Ogataea polymorpha
Synthetic and Systems Biotechnology, 2022 Bio-manufacturing via microbial cell factory requires large promoter library for fine-tuned metabolic engineering. Ogataea polymorpha, one of the methylotrophic yeasts, possesses advantages in broad substrate spectrum, thermal-tolerance, and capacity to ...
Chunxiao Yan +6 more
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Plant Metabolic Engineering [PDF]
Plant Physiology, 2001 Metabolic engineering is generally defined as the redirection of one or more enzymatic reactions to produce new compounds in an organism, improve the production of existing compounds, or mediate the degradation of compounds.
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The LASER database: Formalizing design rules for metabolic engineering
Metabolic Engineering Communications, 2015 The ability of metabolic engineers to conceptualize, implement, and evaluate strain designs has dramatically increased in the last decade. Unlike other engineering fields, no centralized, open-access, and easily searched repository exists for cataloging ...
James D. Winkler +2 more
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Advanced Strategies for Production of Natural Products in Yeast
iScience, 2020 Natural products account for more than 50% of all small-molecule pharmaceutical agents currently in clinical use. However, low availability often becomes problematic when a bioactive natural product is promising to become a pharmaceutical or leading ...
Ruibing Chen +3 more
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Expanding metabolic engineering algorithms using feasible space and shadow price constraint modules
Metabolic Engineering Communications, 2014 While numerous computational methods have been developed that use genome-scale models to propose mutants for the purpose of metabolic engineering, they generally compare mutants based on a single criteria (e.g., production rate at a mutant׳s maximum ...
Christopher J. Tervo, Jennifer L. Reed
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Biology, 2021 β-alanine is widely used as an intermediate in industrial production. However, the low production of microbial cell factories limits its further application.
Jian Xu, Li Zhou, Zhemin Zhou
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Synthetic and Systems Biotechnology, 2018 Advances in metabolic engineering and synthetic biology have facilitated the manufacturing of many valuable-added compounds and commodity chemicals using microbial cell factories in the past decade.
Lihong Jiang +3 more
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Systems Metabolic Engineering of Industrial Microorganisms
Microorganisms, 2023 The green and sustainable production of chemicals, materials, fuels, food, and pharmaceuticals has become a key solution to the global energy and environmental crisis [...]
Xueqin Lv +3 more
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Advances on systems metabolic engineering of Bacillus subtilis as a chassis cell
Synthetic and Systems Biotechnology, 2020 The Gram-positive model bacterium Bacillus subtilis, has been broadly applied in various fields because of its low pathogenicity and strong protein secretion ability, as well as its well-developed fermentation technology. B.
Mengjie Xiang, Qian Kang, Dawei Zhang
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