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Metabolic engineering has developed as a very powerful approach to optimising industrial fermentation processes through the introduction of directed genetic changes using recombinant DNA technology. Successful metabolic engineering starts with a careful analysis of cellular function; based on the results of this analysis, an improved strain is designed
中村 憲夫+3 more
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Plant Metabolic Engineering [PDF]
Metabolic engineering is generally defined as the redirection of one or more enzymatic reactions to produce new compounds in an organism, improve the production of existing compounds, or mediate the degradation of compounds.
Dean DellaPenna
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Introduction to Metabolic Engineering Communications
Ryan T. Gill, Vassily Hatzimanikatis
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Engineering Cellular Metabolism [PDF]
Metabolic engineering is the science of rewiring the metabolism of cells to enhance production of native metabolites or to endow cells with the ability to produce new products. The potential applications of such efforts are wide ranging, including the generation of fuels, chemicals, foods, feeds, and pharmaceuticals.
Jens Nielsen+3 more
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Metabolic engineering of sesquiterpene metabolism in yeast [PDF]
AbstractTerpenes are structurally diverse compounds that are of interest because of their biological activities and industrial value. These compounds consist of chirally rich hydrocarbon backbones derived from terpene synthases, which are subsequently decorated with hydroxyl substituents catalyzed by terpene hydroxylases.
Shunji Takahashi+8 more
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Metabolic engineering: Tools and applications
Yun Chen, Jiazhang Lian, Jin Hou
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The virus as metabolic engineer [PDF]
AbstractRecent genome‐wide screens of host genetic requirements for viral infection have reemphasized the critical role of host metabolism in enabling the production of viral particles. In this review, we highlight the metabolic aspects of viral infection found in these studies, and focus on the opportunities these requirements present for metabolic ...
Miriam V. Gutschow+3 more
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Advances in the optimization of central carbon metabolism in metabolic engineering
Central carbon metabolism (CCM), including glycolysis, tricarboxylic acid cycle and the pentose phosphate pathway, is the most fundamental metabolic process in the activities of living organisms that maintains normal cellular growth.
Zhenke Wu+7 more
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The future of metabolic engineering and synthetic biology: Towards a systematic practice [PDF]
Industrial biotechnology promises to revolutionize conventional chemical manufacturing in the years ahead, largely owing to the excellent progress in our ability to re-engineer cellular metabolism.
De Mey, Marjan+4 more
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