Results 31 to 40 of about 623,308 (344)

Advances on systems metabolic engineering of Bacillus subtilis as a chassis cell

Synthetic and Systems Biotechnology, 2020
The Gram-positive model bacterium Bacillus subtilis, has been broadly applied in various fields because of its low pathogenicity and strong protein secretion ability, as well as its well-developed fermentation technology. B.
Mengjie Xiang, Qian Kang, Dawei Zhang
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Aromatic Plants Metabolic Engineering: A Review

Agronomy, 2022
Secondary metabolites of aromatic plants are used in many health applications as drugs, pheromones, insecticides, fragrances, and antioxidants. Due to the huge commercial demand for these secondary metabolites, the need to overcome the insufficient ...
Olga V. Shelepova, Ekaterina N. Baranova, Ekaterina V. Tkacheva, Yulia B. Evdokimenkova, Aleksandr A. Ivanovskii, Ludmila N. Konovalova, Alexander A. Gulevich   +6 more
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Metabolic network modularity arising from simple growth processes

, 2012
Metabolic networks consist of linked functional components, or modules. The mechanism underlying metabolic network modularity is of great interest not only to researchers of basic science but also to those in fields of engineering.
Takemoto, Kazuhiro
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The Studies in Constructing Yeast Cell Factories for the Production of Fatty Acid Alkyl Esters

Frontiers in Bioengineering and Biotechnology, 2022
Fatty acid alkyl esters have broad applications in biofuels, lubricant formulas, paints, coatings, and cosmetics. Traditionally, these esters are mostly produced through unsustainable and energy-intensive processes.
Yang Zhang, Yang Zhang, Xiao Guo, Huaiyi Yang, Shuobo Shi   +4 more
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Reconstruction of metabolic networks from high-throughput metabolite profiling data: in silico analysis of red blood cell metabolism

, 2007
We investigate the ability of algorithms developed for reverse engineering of transcriptional regulatory networks to reconstruct metabolic networks from high-throughput metabolite profiling data.
Barbagallo M., Butte A.J., C. J. UNKEFER, Frenkel E., G. S. ESCOLA, Garay R., I. NEMENMAN, Jacobasch G., Katz L., Kemp G., Kirk K., M. E. WALL, Mendes P., P. J. UNKEFER, Rose I., Steinhauser D., W. S. HLAVACEK, Walser M., Wang K.   +18 more
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Unleashing the power of energy storage: Engineering β-oxidation pathways for polyketide production

Synthetic and Systems Biotechnology, 2020
Overproduction of polyketides has been a challenge for metabolic engineering for decades. However, recent studies have demonstrated that in both native host and heterologous host, engineering β -oxidation pathways can lead to dramatic improvement of ...
Bin Wang, Huimin Zhao
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Metabolic engineering of roseoflavin-overproducing microorganisms

Microbial Cell Factories, 2019
Background Roseoflavin, a promising broad-spectrum antibiotic, is naturally produced by the bacteria Streptomyces davaonensis and Streptomyces cinnabarinus.
Rodrigo Mora-Lugo, Julian Stegmüller, Matthias Mack   +2 more
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Algorithms for Molecular Biology / Designing minimal microbial strains of desired functionality using a genetic algorithm [PDF]

, 2015
Background: The rational, in silico prediction of gene-knockouts to turn organisms into efficient cell factories is an essential and computationally challenging task in metabolic engineering.
Hanscho, Michael, Jungreuthmayer, Christian, Nair, Govind, Zanghellini, J\ufcrgen   +3 more
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CRISPR/Cas9 advances engineering of microbial cell factories [PDF]

, 2016
One of the key drivers for successful metabolic engineering in microbes is the efficacy by which genomes can be edited. As such there are many methods to choose from when aiming to modify genomes, especially those of model organisms like yeast and ...
Jakociunas, Tadas, Jensen, Michael Krogh, Keasling, Jay D.   +2 more
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Genomic and proteomic biases inform metabolic engineering strategies for anaerobic fungi. [PDF]

, 2020
Anaerobic fungi (Neocallimastigomycota) are emerging non-model hosts for biotechnology due to their wealth of biomass-degrading enzymes, yet tools to engineer these fungi have not yet been established.
Albà, Arazoe, Atasoglu, Bach, Beckham, Bezanson, Birdsell, Boch, Bonugli-Santos, Brownlee, Calkins, Camacho, Camiolo, Carlson, Chan, Chen, Cheng, Cheng, Chokhawala, Coker, Deshpande, Diener, Dollhofer, Duarte, Durand, Duret, Fondon, Galtier, Gasiunas, Gentzsch, Gerngross, Glass, Glémin, Greene, Grigoriev, Haitjema, Haitjema, Hamilton, Hanafy, Hartfield, Henske, Hershberg, Hildebrand, Hull, Jiang, Karlin, Kiktev, Kleinstiver, Kleinstiver, Knauer, Knight, Kuyper, Leberer, Li, Liggenstoffer, Liu, Magee, Mertens, Meunier, Morrison, Murphy, Nicholson, Nieuwenhuis, Nørholm, Orpin, Oyola, O’Malley, Podolsky, Raymond, Reichenberger, Ropars, Sadhu, Sammond, Sekowska, Seppälä, Seppälä, Solieri, Solomon, Sonan, Staben, Steensels, Steensels, Sukumaran, Theodorou, UniProt: a worldwide hub of protein knowledge, Videvall, Wang, Wang, Wright, Wu, Ximenes, Youssef, Zetsche   +92 more
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