Results 61 to 70 of about 574,220 (331)

Back to the future: Why we need enzymology to build a synthetic metabolism of the future

Beilstein Journal of Organic Chemistry, 2019
Biology is turning from an analytical into a synthetic discipline. This is especially apparent in the field of metabolic engineering, where the concept of synthetic metabolism has been recently developed.
Tobias J. Erb
doaj   +1 more source

Goodbye flat lymphoma biology

FEBS Letters, EarlyView.
Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria, Cèlia Dobaño‐López, Patricia Pérez‐Galán, Christine Bezombes   +3 more
wiley   +1 more source

Grounding knowledge and normative valuation in agent-based action and scientific commitment [PDF]

, 2018
Philosophical investigation in synthetic biology has focused on the knowledge-seeking questions pursued, the kind of engineering techniques used, and on the ethical impact of the products produced.
A Clark, A Clark, A Clark, A Minelli, A Pickering, B Calcott, B Goodwin, C Kendig, C Kendig, C Kendig, C Swanton, D Dellomonaco, D Endy, D Erwin, D Gibson, D Sprinzak, EF Keller, EJ Lowe, G Wagner, H Chang, H Chang, H Chang, H Chang, H Longino, H-J Rheinberger, I Hacking, I Hacking, J Dupré, J Dupré, J Hornsby, J Rouse, J Rouse, Latour, B./Johnson, J, M Grene, M Grene, M Kirschner, M Morange, M Morange, M O’Malley, M O’Malley, M Polanyi, M West-Eberhard, M West-Eberhard, P Mullins, P Schyfter, R Brent, R Georgianna, R Wilson, TT Eckdahl, VJ Martin, Weihua Wang   +50 more
core   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Plant cell packs: a scalable platform for recombinant protein production and metabolic engineering [PDF]

, 2019
Industrial plant biotechnology applications include the production of sustainable fuels, complex metabolites and recombinant proteins, but process development can be impaired by a lack of reliable and scalable screening methods. Here, we describe a rapid
Arfi, Bendandi, Buyel, Buyel, Buyel, Buyel, Buyel, Buyel, Fradkov, Geli, Goojani, Holland, Howat, Kingsbury, Matz, Munro, Muster, Noe, Pennings, Piotrzkowski, Prasher, Sangwan, Simmons, Spiegel, Staniek, Trkola, Turpen, Wong, Zhong   +28 more
core   +1 more source

Mycobacterium tuberculosis sulfurtransferase SseA is activated by its neighboring gene product Rv3284

FEBS Letters, EarlyView.
Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli, Alex Fissore, Edoardo Salladini, Eleonora Raccuia, Simonetta Oliaro‐Bosso, Alessia Ruggiero, Rita Berisio, Milagros Medina, Adrian Velazquez‐Campoy, Salvatore Adinolfi, Mauro Marengo   +10 more
wiley   +1 more source

The LASER database: Formalizing design rules for metabolic engineering

Metabolic Engineering Communications, 2015
The ability of metabolic engineers to conceptualize, implement, and evaluate strain designs has dramatically increased in the last decade. Unlike other engineering fields, no centralized, open-access, and easily searched repository exists for cataloging ...
James D. Winkler, Andrea L. Halweg-Edwards, Ryan T. Gill   +2 more
doaj  

Division of Metabolic Engineering [PDF]

, 2008
この論文は国立情報学研究所の学術雑誌公開支援事業により電子化されまし
Ali MahmoudEl-Halawany, 服部 征雄, 鄭 美和, 馬 超美   +3 more
core   +1 more source

Algorithms for Molecular Biology / Designing minimal microbial strains of desired functionality using a genetic algorithm [PDF]

, 2015
Background: The rational, in silico prediction of gene-knockouts to turn organisms into efficient cell factories is an essential and computationally challenging task in metabolic engineering.
Hanscho, Michael, Jungreuthmayer, Christian, Nair, Govind, Zanghellini, J\ufcrgen   +3 more
core   +1 more source

Erythrocytes as Carriers of Therapeutic Enzymes. [PDF]

, 2020
Therapeutic enzymes are administered for the treatment of a wide variety of diseases. They exert their effects through binding with a high affinity and specificity to disease-causing substrates to catalyze their conversion to a non-noxious product, to ...
Bax, BE
core   +1 more source