Results 61 to 70 of about 595,354 (350)

Department of Metabolic Engineering [PDF]

, 2002
薬物代謝工学部門は和漢薬の薬効，毒性発現に関与する代謝系の分子生物学的研究を発展させることを設置目的とし，①和漢薬の薬効発現に関与する腸内細菌遺伝子の解析，②薬物代謝機能調節遺伝子の解明とその応用，③腎毒性物質産生機構の分子生物学的解明とその制御に関する研究を課題として取りあげ，和漢薬の薬効発現機構，生体へのレスポンスなどの基礎的研究を通じて，和漢薬の科学的評価や臨床応用をはかることを目指している。主な研究題目を以下に示す。1.
中村 憲夫, 宮代 博継, 服部 征雄, 横澤 隆子   +3 more
core   +2 more sources

The future of metabolic engineering and synthetic biology: Towards a systematic practice [PDF]

, 2012
Industrial biotechnology promises to revolutionize conventional chemical manufacturing in the years ahead, largely owing to the excellent progress in our ability to re-engineer cellular metabolism.
De Mey, Marjan, Kumaran Ajikumar, Parayil, Lim, Chin Giaw, Stephanopoulos, Gregory, Yadav, Vikramaditya G.   +4 more
core   +1 more source

Genetic and metabolic engineering in diatoms [PDF]

Philosophical Transactions of the Royal Society B: Biological Sciences, 2017
Diatoms have attracted considerable attention due to their success in diverse environmental conditions, which probably is a consequence of their complex origins. Studies of their metabolism will provide insight into their adaptation capacity and are a prerequisite for metabolic engineering.
Weichao Huang, Fayza Daboussi
openaire   +4 more sources

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

FEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan, Victoria Scarpelli, Marten Exterkate   +2 more
wiley   +1 more source

The automated Galaxy-SynBioCAD pipeline for synthetic biology design and engineering

Nature Communications, 2022
Automated design and build processes can rapidly accelerate work in synthetic biology and metabolic engineering. Here the authors present Galaxy-SynBioCAD, a toolshed for synthetic biology, metabolic engineering, and industrial biotechnology that they ...
Joan Hérisson, Thomas Duigou, Melchior du Lac, Kenza Bazi-Kabbaj, Mahnaz Sabeti Azad, Gizem Buldum, Olivier Telle, Yorgo El Moubayed, Pablo Carbonell, Neil Swainston, Valentin Zulkower, Manish Kushwaha, Geoff S. Baldwin, Jean-Loup Faulon   +13 more
doaj   +1 more source

Reconstruction of an in silico metabolic model of _Arabidopsis thaliana_ through database integration [PDF]

, 2009
The number of genome-scale metabolic models has been rising quickly in recent years, and the scope of their utilization encompasses a broad range of applications from metabolic engineering to biological discovery.
Albert Gevorgyan, Jean-Marc Schwartz, Karin Radrich, Neil Swainston, Paul Dobson, Yoshimasa Tsuruoka   +5 more
core   +1 more source

Synthetic RNA Silencing of Actinorhodin Biosynthesis in Streptomyces coelicolor A3(2) [PDF]

, 2013
We demonstrate the first application of synthetic RNA gene silencers in Streptomyces coelicolor A3(2). Peptide nucleic acid and expressed antisense RNA silencers successfully inhibited actinorhodin production.
A Hesketh, Andrew Hesketh, CG Hebert, D D'alia, E Wagner, F Flett, Gabriel C. Uguru, GC Uguru, H Aiba, IL Hofacker, J Livny, J Livny, J Pánek, James E. M. Stach, JP Swiercz, L Good, L Good, Liam Good, LS Waters, M McArthur, M McArthur, Madhav Mondhe, Mark Isalan, Mervyn J. Bibb, MP Vockenhuber, MP Vockenhuber, MW Pfaffl, N Nakashima, N Nekhotiaeva, N Shen, NM Romero, NM Romero, P Hindra, R Dryselius, RP Desai, S Goh, S Herai, SG Kang, Shan Goh, T Morita, T Tezuka, TA Hjalt, W Minas, Y Chen   +43 more
core   +4 more sources

Computational Approaches in Metabolic Engineering [PDF]

Journal of Biomedicine and Biotechnology, 2010
Metabolic engineering involves the adjustment of metabolic and regulatory processes to improve desired cellular behaviors, such as the production of proteins and chemicals. Since cellular metabolic and regulatory networks are often large and complex, the construction and analysis of computational models of these networks can be useful for identifying ...
Jennifer L. Reed, Jamey D. Young, Ryan S. Senger, Maciek R. Antoniewicz   +3 more
openaire   +2 more sources

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

FEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile, Daniela Ratto, Giorgia Rastelli, Ottavia Eleonora Ferraro, Caterina Temporini, Sunil Kumar, Simona Boncompagni, Paola Rossi, Monica Canepari   +8 more
wiley   +1 more source

Comprehensive evaluation of the capacities of microbial cell factories

Nature Communications
Systems metabolic engineering is facilitating the development of high-performing microbial cell factories for producing chemicals and materials. However, constructing an efficient microbial cell factory still requires exploring and selecting various host
Gi Bae Kim, Ha Rim Kim, Sang Yup Lee
doaj   +1 more source