Results 51 to 60 of about 363,947 (345)

Phylophenetic properties of metabolic pathway topologies as revealed by global analysis

BMC Bioinformatics, 2006
Background As phenotypic features derived from heritable characters, the topologies of metabolic pathways contain both phylogenetic and phenetic components.
Sun Shiwei, Zhang Zefeng, Zhu Xiaopeng, Zhang Zhihua, Skogerbø Geir, Li Shaojuan, Zhang Yong, Lu Hongchao, Shi Baochen, Chen Runsheng   +9 more
doaj   +1 more source

Flux-based classification of reactions reveals a functional bow-tie organization of complex metabolic networks

, 2012
Unraveling the structure of complex biological networks and relating it to their functional role is an important task in systems biology. Here we attempt to characterize the functional organization of the large-scale metabolic networks of three ...
Giri, Varun, Jain, Sanjay, Krishna, Sandeep, Raghuram, Nandula, Samal, Areejit, Singh, Shalini   +5 more
core   +3 more sources

Quantitative proteomic characterization of human sperm cryopreservation: using data-independent acquisition mass spectrometry

BMC Urology, 2019
Background Human sperm cryopreservation is a simple and effective approach for male fertility preservation. Methods To identify potential proteomic changes in this process, data-independent acquisition (DIA), a technology with high quantitative accuracy ...
Longlong Fu, Qi An, Kaishu Zhang, Ying Liu, Yue Tong, Jianfeng Xu, Fang Zhou, Xiaowei Wang, Ying Guo, Wenhong Lu, Xiaowei Liang, Yiqun Gu   +11 more
doaj   +1 more source

A genome scale metabolic network for rice and accompanying analysis of tryptophan, auxin and serotonin biosynthesis regulation under biotic stress [PDF]

, 2013
Background Functional annotations of large plant genome projects mostly provide information on gene function and gene families based on the presence of protein domains and gene homology, but not necessarily in association with gene expression or ...
Amarasinghe, V., Dharmawardhana, P., Jaiswal, P., McCouch, S., Monaco, M., Ravenscroft, D., Ren, L. Y., Thomason, J., Ware, D.   +8 more
core   +2 more sources

Organellar carbon metabolism is co-ordinated with distinct developmental phases of secondary xylem [PDF]

, 2019
Subcellular compartmentation of plant biosynthetic pathways in the mitochondria and plastids requires coordinated regulation of nuclear encoded genes, and the role of these genes has been largely ignored by wood researchers. In this study, we constructed
Fierro Gutierrez, Ana Carolina Elisa, Marchal, Kathleen, Mizrachi, Eshchar, Myburg, Alexander A, Pinard, Desré   +4 more
core   +2 more sources

Cancer metabolism: a modeling perspective

Frontiers in Physiology, 2015
Tumor cells alter their metabolism to maintain unregulated cellular proliferation and survival, but this transformation leaves them reliant on constant supply of nutrients and energy.
Pouyan eGhaffari Nouran, Adil eMardinoglu, Adil eMardinoglu, Jens eNielsen, Jens eNielsen, Jens eNielsen   +5 more
doaj   +1 more source

Role of Proton-Coupled Monocarboxylate Transporters in Cancer: From Metabolic Crosstalk to Therapeutic Potential

Frontiers in Cell and Developmental Biology, 2020
Proton-coupled monocarboxylate transporters (MCTs), representing the first four isoforms of the SLC16A gene family, mainly participate in the transport of lactate, pyruvate, and other monocarboxylates.
Xiangyu Sun, Mozhi Wang, Mengshen Wang, Litong Yao, Xinyan Li, Haoran Dong, Meng Li, Tie Sun, Xing Liu, Yang Liu, Yingying Xu   +10 more
doaj   +1 more source

Improved Network Performance via Antagonism: From Synthetic Rescues to Multi-drug Combinations [PDF]

, 2010
Recent research shows that a faulty or sub-optimally operating metabolic network can often be rescued by the targeted removal of enzyme-coding genes--the exact opposite of what traditional gene therapy would suggest.
Adilson E. Motter, Baba, Blagosklonny, Bollenbach, Bourgeois, Burgard, Burgard, Cagatay, Chait, Cun, Dancey, Duarte, Edwards, Feist, Fischer, Fong, Fong, Fong, Fong, Fraenkel, Gerdes, Giaever, Goebl, Harrison, Hashimoto, Hegreness, Henry, Herring, Hilgetag, Hilgetag, Hillenmeyer, Hopkins, Huttenlocher, Huttenlocher, Isalan, Kauffman, Keiser, Kim, Kitano, Kupiec, Ma, Miller, Motter, Motter, Nishikawa, Olson, Palsson, Papp, Pharkya, Reguly, Segre, Segre, Shlomi, Timmermans, Wagner, Yeh, Yildirim, Yngvadottir, Zamboni   +58 more
core   +3 more sources

CircRNA-Associated ceRNA Network Reveals Focal Adhesion and Metabolism Pathways in Neuropathic Pain

Journal of Oncology, 2022
Background. Increasing evidence has shown that noncoding RNAs perform a remarkable function in neuropathic pain (NP); nonetheless, the mechanisms underlying the modulation of competitive endogenous RNA in NP remain uncertain. The goal of this research was to investigate the molecular processes underlying NP. Methods.
Kun Wang, Jun-Ping Bao, Zhi-Min Zhou, Lu Mao, Xiao-Tao Wu   +4 more
openaire   +2 more sources

MicroRNA regulation of bovine monocyte inflammatory and metabolic networks in an in vivo infection model. [PDF]

, 2014
peer-reviewedBovine mastitis is an inflammation-driven disease of the bovine mammary gland that costs the global dairy industry several billion dollars per annum.
Baker, Mike, Bryan, Kenneth, Lawless, Nathan, Lippolis, John D., Lynn, David J, O'Farrelly, Cliona, Pesch, Bruce, Reinhardt, Timothy A., Sonstegard, Tad, Zimmerman, Duane, Zuelke, Kurt   +10 more
core   +1 more source