Results 1 to 10 of about 4,047,137 (345)
The landscape of metabolic pathway dependencies in cancer cell lines.
PLoS Computational Biology, 2021 The metabolic reprogramming of cancer cells creates metabolic vulnerabilities that can be therapeutically targeted. However, our understanding of metabolic dependencies and the pathway crosstalk that creates these vulnerabilities in cancer cells remains ...
James H Joly +2 more
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Astrocyte metabolism and signaling pathways in the CNS
Frontiers in Neuroscience, 2023 Astrocytes comprise half of the cells in the central nervous system and play a critical role in maintaining metabolic homeostasis. Metabolic dysfunction in astrocytes has been indicated as the primary cause of neurological diseases, such as depression ...
Yong-mei Zhang +17 more
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Metabolomics Analysis of Lettuce (Lactuca sativa L.) Affected by Low Potassium Supply
Agriculture, 2022 Lettuce is a commercially significant leafy vegetable worldwide. Potassium (K) is an essential macronutrient for lettuce growth and development and significantly impacts its metabolites.
Hongyan Gao +3 more
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Low-Cost Algorithms for Metabolic Pathway Pairwise Comparison
Biomimetics, 2022 Metabolic pathways provide key information for achieving a better understanding of life and all its processes; this is useful information for the improvement of medicine, agronomy, pharmacy, and other similar areas.
Esteban Arias-Méndez +2 more
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Gut Microbiome Alterations in Patients With Carotid Atherosclerosis
Frontiers in Cardiovascular Medicine, 2021 Carotid atherosclerosis (CAS) is a reflection of systemic atherosclerosis and the main pathological processes of cardiovascular disease (CVD), namely, carotid intima–media thickening, carotid plaque formation, and carotid stenosis.
Jingfeng Chen +10 more
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Metabolic reprogramming in osteosarcoma
Pediatric Discovery, 2023 Tumor cells undergo metabolic reprogramming to meet their energy and anabolic demands to maintain their malignant phenotype. Activation of oncogenes and deletion of tumor suppressors promotes metabolic reprogramming in cancer by directly or indirectly ...
Yulu Shi, Xiaohan Yue, Qing Luo
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Frontiers in Pharmacology, 2021 Andrographolide (Andro) has known to treat various illnesses such as colds, diarrhea, fever and infectious diseases. However, the effect mechanism of Andro is still unclear. Therefore, we used high-throughput metabolomics analysis to discover biomarkers,
Wen Luo +6 more
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A newton cooperative genetic algorithm method for in silico optimization of metabolic pathway production. [PDF]
PLoS ONE, 2015 This paper presents an in silico optimization method of metabolic pathway production. The metabolic pathway can be represented by a mathematical model known as the generalized mass action model, which leads to a complex nonlinear equations system.
Mohd Arfian Ismail +3 more
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Frontiers in Microbiology, 2021 Xiaoqu, one of three traditional jiuqu in China, is a saccharifying and fermenting agent used in Xiaoqu jiu brewing, with different ingredient compositions and preparation techniques used in various regions.
Chi Zhao +7 more
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Frontiers in Genetics, 2021 Cardiovascular diseases (CVDs) remain the main cause of morbidity and mortality worldwide. The pathological mechanism and underlying biological processes of these diseases with metabolites remain unclear.
Jiahao Qiao +8 more
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