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The landscape of metabolic pathway dependencies in cancer cell lines.
PLoS Computational Biology, 2021 The metabolic reprogramming of cancer cells creates metabolic vulnerabilities that can be therapeutically targeted. However, our understanding of metabolic dependencies and the pathway crosstalk that creates these vulnerabilities in cancer cells remains ...
James H Joly +2 more
doaj +2 more sources
Gut microbes, 2021 Emerging evidence suggests that the gut microbiota may interact with the host brain and play pivotal roles in the pathogenesis of neuropsychiatric disorders. However, the mechanism underlying reciprocal interactions along the microbiota-gut-brain axis in
Yuanyuan Deng +8 more
semanticscholar +1 more source
Immune Influencers in Action: Metabolites and Enzymes of the Tryptophan-Kynurenine Metabolic Pathway
Biomedicines, 2021 The tryptophan (TRP)-kynurenine (KYN) metabolic pathway is a main player of TRP metabolism through which more than 95% of TRP is catabolized. The pathway is activated by acute and chronic immune responses leading to a wide range of illnesses including ...
Masaru Tanaka +5 more
semanticscholar +1 more source
WormPaths: Caenorhabditis elegans metabolic pathway annotation and visualization
Genetics, 2021 In our group, we aim to understand metabolism in the nematode Caenorhabditis elegans and its relationships with gene expression, physiology, and the response to therapeutic drugs.
Melissa D. Walker +17 more
semanticscholar +1 more source
Astrocyte metabolism and signaling pathways in the CNS
Frontiers in Neuroscience, 2023 Astrocytes comprise half of the cells in the central nervous system and play a critical role in maintaining metabolic homeostasis. Metabolic dysfunction in astrocytes has been indicated as the primary cause of neurological diseases, such as depression ...
Yong-mei Zhang +17 more
doaj +1 more source
Comput. Math. Methods Medicine, 2021 Metabolic pathway is an important type of biological pathways. It produces essential molecules and energies to maintain the life of living organisms.
Yuanyuan Zhu, Bin Hu, Lei Chen, Qi Dai
semanticscholar +1 more source
Metabolomics Analysis of Lettuce (Lactuca sativa L.) Affected by Low Potassium Supply
Agriculture, 2022 Lettuce is a commercially significant leafy vegetable worldwide. Potassium (K) is an essential macronutrient for lettuce growth and development and significantly impacts its metabolites.
Hongyan Gao +3 more
doaj +1 more source
Low-Cost Algorithms for Metabolic Pathway Pairwise Comparison
Biomimetics, 2022 Metabolic pathways provide key information for achieving a better understanding of life and all its processes; this is useful information for the improvement of medicine, agronomy, pharmacy, and other similar areas.
Esteban Arias-Méndez +2 more
doaj +1 more source
A metabolic pathway for bile acid dehydroxylation by the gut microbiome
Nature, 2020 The gut microbiota synthesize hundreds of molecules, many of which influence host physiology. Among the most abundant metabolites are the secondary bile acids deoxycholic acid (DCA) and lithocholic acid (LCA), which accumulate at concentrations of around
Masanori Funabashi +9 more
semanticscholar +1 more source
Isoprene oxidation by the gram-negative model bacterium variovorax sp. WS11 [PDF]
, 2020 Plant-produced isoprene (2-methyl-1,3-butadiene) represents a significant portion of global volatile organic compound production, equaled only by methane.
Crombie, Andrew T. +4 more
core +1 more source