Results 41 to 50 of about 4,047,137 (345)
Pathway analysis of NAD+ metabolism [PDF]
Biochemical Journal, 2011 NAD+ is well known as a crucial cofactor in the redox balance of metabolism. Moreover, NAD+ is degraded in ADP-ribosyl transfer reactions, which are important components of multitudinous signalling reactions. These include reactions linked to DNA repair and aging.
Toni I. Gossmann +5 more
openaire +4 more sources
A deep learning architecture for metabolic pathway prediction
Bioinform., 2019 Motivation Understanding the mechanisms and structural mappings between molecules and pathway classes are critical for design of reaction predictors for synthesizing new molecules.
Mayank Baranwal +5 more
semanticscholar +1 more source
Frontiers in Pharmacology, 2020 Chronic glomerulonephritis (CGN) as the culprit of kidney failure can increase the mortality of critically ill patients and seriously threatens people’s health all over the world.
Wei Yu +3 more
doaj +1 more source
Scientific Reports, 2018 Curcumin has been reported to exhibit anti-tumorigenic activity; however, since its precise actions remain unclear, its effects are considered to be deceptive.
Y. Larasati +5 more
semanticscholar +1 more source
Restoring a Metabolic Pathway [PDF]
ACS Chemical Biology, 2008 Gluconeogenesis is blocked in a strain of Escherichia coli that is deficient in triosephosphate isomerase, but it was restored by the insertion of a plasmid coding for an L-glyceraldehyde 3-phosphate reductase (YghZ). This reductase provides a "bypass" that produces dihydroxyacetone phosphate (DHAP) by the consecutive enzyme-catalyzed reduction of L ...
openaire +3 more sources
Metabolic pathways for the whole community [PDF]
BMC Genomics, 2014 Background. A convergence of high-throughput sequencing and computational power is transforming biology into information science. Despite these technological advances, converting bits and bytes of sequence information into meaningful insights remains a challenging enterprise.
Hanson, Niels W +5 more
openaire +4 more sources
The Brain NGF Metabolic Pathway in Health and in Alzheimer’s Pathology
Frontiers in Neuroscience, 2019 Emerging research has re-emphasized the role of the cortical cholinergic system in the symptomology and progression of Alzheimer’s disease (AD). Basal forebrain (BF) cholinergic nuclei depend on target-derived NGF for survival during development and for ...
A. Cuello, R. Pentz, H. Hall
semanticscholar +1 more source
Metabolic Pathways of Acylcarnitine Synthesis
Physiological Research, 2023 Acylcarnitines are important markers in metabolic studies of many diseases, including metabolic, cardiovascular, and neurological disorders. We reviewed analytical methods for analyzing acylcarnitines with respect to the available molecular structural information, the technical limitations of legacy methods, and the potential of new mass spectrometry ...
Jana Brejchova +2 more
openaire +3 more sources
Frontiers in Microbiology, 2019 Although the biological processes of organism under hypoxic stress had been elucidated, the whole physiological changes of Saccharomyces cerevisiae are still unclear. In this work, we investigated the changes of biological process of S.
Zhengchao Xia +9 more
semanticscholar +1 more source
Glutamine supports pancreatic cancer growth through a Kras-regulated metabolic pathway
Nature, 2013 Cancer cells have metabolic dependencies that distinguish them from their normal counterparts. Among these dependencies is an increased use of the amino acid glutamine to fuel anabolic processes.
J. Son +17 more
semanticscholar +1 more source