Results 91 to 100 of about 159,394 (302)

Metabolic Changes in Zebrafish Larvae Infected with Mycobacterium marinum: A Widely Targeted Metabolomic Analysis

Metabolites
Objectives: To explore the metabolic changes in zebrafish larvae after infection with Mycobacterium marinum, this study adopted a widely targeted metabolomic approach to analyze the changes in the overall metabolic profiles of zebrafish larvae infected ...
Chongyuan Sima, Qifan Zhang, Xiaoli Yu, Bo Yan, Shulin Zhang   +4 more
doaj   +1 more source

Organic Materials of Tomorrow: Horizons of Artificial Intelligence

Advanced Materials, EarlyView.
This review examines machine learning techniques accelerating the discovery of organic semiconductors by linking molecular structure to properties. Key methods include graph neural networks, generative models, and active learning. Applications to organic photovoltaics demonstrate practical impact.
Harold Mena, J. Terence Blaskovits, Kun‐Han Lin, Denis Andrienko   +3 more
wiley   +1 more source

Targeted metabolomic profiling of acute ST-segment elevation myocardial infarction

Scientific Reports
Myocardial infarction is a major cause of morbidity and mortality worldwide. Metabolomic investigations may be useful for understanding the pathogenesis of ST-segment elevation myocardial infarction (STEMI).
Sergey S. Markin, E. A. Ponomarenko, Yu. A Romashova, T. O. Pleshakova, S. V. Ivanov, V. V. Beregovykh, S. L. Konstantinov, G. I. Stryabkova, Zh. Yu. Chefranova, Y. A. Lykov, I. M. Karamova, A. G. Koledinskii, K. M. Shestakova, P. A. Markin, N. E. Moskaleva, S. A. Appolonova   +15 more
doaj   +1 more source

Integrated Metabolomic and Transcriptomic Analysis of Nitraria Berries Indicate the Role of Flavonoids in Adaptation to High Altitude

Metabolites
Background: Plants of Nitraria, belonging to the Zygophyllaceae family, are not only widely distributed at an altitude of about 1000 m but also at an altitude of about 3000 m, which is a rare phenomenon.
Qing Zhao, Jie Zhang, Yanhong Li, Zufan Yang, Qian Wang, Qiangqiang Jia   +5 more
doaj   +1 more source

Insight into the role of grafting and arbuscular mycorrhiza on cadmium stress tolerance in tomato

Frontiers in Plant Science, 2015
Physiological, biochemical, metabolite changes and gene expression analysis of greenhouse tomato (Solanum lycopersicumL.) were investigated in two grafting combinations (self-grafted ‘Ikram’ and ‘Ikram’ grafted onto interspecific hybrid rootstock ...
Pradeep eKumar, Luigi eLucini, Youssef eRouphael, Mariateresa eCardarelli, Raviraj M Kalunke, Giuseppe eColla   +5 more
doaj   +1 more source

Ionic Gating of Liquid‐Crystal‐Like Pteridine Assemblies Enables Tunable Light Scattering

Advanced Materials, EarlyView.
Tunable optical properties emerge through developmentally regulated ionic gating, which transforms disordered, ultraviolet (UV)‐absorbing organelles into concentrically ordered, liquid‐crystal‐like light scatterers. By integrating analyses of pteridine composition, potassium‐dependent assembly, hierarchical ultrastructure, and optical behavior, the ...
Sourabh Bera, Zohar Eyal, Yael Noy, Yuval Barzilay, Siddharth Sahoo, Srikant Moharana, Avi Baram, Tali Lerer‐Goldshtein, Neta Varsano, Bar Bader, Lothar Houben, Uwe Heinig, Iddo Pinkas, Moshe Goldsmith, Tamar Unger, Shira Albeck, Andrea Sorrentino, Maxim Itkin, Sergey Malitsky, Ziv Porat, Ido Hadar, Venkata Jayasurya Yallapragada, Dvir Gur   +22 more
wiley   +1 more source

Metabolomic changes of the multi (-AGC-) kinase inhibitor AT13148 in cells, mice and patients are associated with NOS regulation [PDF]

, 2020
introduction: To generate biomarkers of target engagement or predictive response for multi-target drugs is challenging. One such compound is the multi-AGC kinase inhibitor AT13148.
Swales, Karen, Decordova, S, Collins, Ian, De Bono, J, Banerji, U, Eccles, Suzanne A ., Henley, Alan T., Asad, Y, Collins, I, Garrett, MD, Ruddle, R, Raynaud, FI, Ruddle, Ruth, Decordova, Shaun, Eccles, SA, Pal, Akos, Garrett, Michelle D., Raynaud, Florence I., De Bono, Johann, Henley, AT, Banerji, Udai, Asad, Yasmin, Swales, K, Pal, A   +23 more
core   +1 more source

HS-SPME-GC-MS Analysis of the Volatile Composition of Italian Honey for Its Characterization and Authentication Using the Genetic Algorithm

Separations
Honey’s chemical and sensory characteristics depend on several factors, including its botanical and geographic origins. The consumers’ increasing interest in monofloral honey and honey with a clear indication of geographic origin make these types of ...
Carlotta Breschi, Francesca Ieri, Luca Calamai, Alessandra Miele, Silvia D’Agostino, Fabrizio Melani, Bruno Zanoni, Nadia Mulinacci, Lorenzo Cecchi   +8 more
doaj   +1 more source

Metabolomics Reveal Induction of ROS Production and Glycosylation Events in Wheat Upon Exposure to the Green Leaf Volatile Z-3-Hexenyl Acetate

Frontiers in Plant Science, 2020
The activation and priming of plant defense upon perception of green leaf volatiles (GLVs) have often been reported. However, information as to which metabolic pathways in plants are affected by GLVs remains elusive.
Maarten Ameye, Maarten Ameye, Lieven Van Meulebroek, Bianca Meuninck, Lynn Vanhaecke, Guy Smagghe, Geert Haesaert, Kris Audenaert   +7 more
doaj   +1 more source

MASH Background Confers Enhanced Disease Susceptibility and Acetaminophen Toxicity in iPSC‐Derived Liver Organoids

Advanced Science, EarlyView.
This work establishes a novel method for generating multicellular liver organoids from control and MASH donor iPSCs. The model recapitulates several disease‐specific characteristics, with MASH donor‐derived organoids showing higher susceptibility. Lipidomic profiling of MASH organoids closely resembles MASH liver biopsies.
Ekta Minocha, Ashwani Kumar Gupta, Nate Schmidt, Richard M. Green, John G. Purdy, Jason A. Wertheim   +5 more
wiley   +1 more source