Results 121 to 130 of about 168,925 (309)

Gastroesophageal Reflux Aspiration in the Post Lung Transplant Patient: a Targeted Bile Acid Metabolomic and Lipidomic Approach.

, 2015
Gastroesophageal Reflux Aspiration in the Post Lung Transplant Patient: a Targeted Bile Acid Metabolomic and Lipidomic ...
Kim C, Shah L, Cremens S, Naroji S, Sonett J, Lederer D, Aramini B, Zhou B, Gilbert DP, D'Ovidio F, Raza K, Arcasoy S, Chan R, Robbins H   +13 more
core  

Metabolic Reprogramming in Glioblastoma Stem Cells Promotes Radiation Resistance Through a H3K18la/USP30/MBOAT2 Axis

Advanced Science, EarlyView.
LDHA‐driven lactate production in mesenchymal glioma stem cells promotes p300‐dependent H3K18 lactylation, activates USP30 transcription, and stabilizes MBOAT2 to remodel phosphatidylethanolamines toward ferroptosis‐resistant PE‐MUFA species. Disrupting this metabolic–epigenetic–lipid circuit enhances ferroptosis and sensitizes glioblastoma to ...
Zong Miao, Wei Gu, Yimin Ren, Chenfei Lu, Wanzhi Cai, Junnan Lu, Zhongyuan Bao, Yanan Zhou, Rong Li, Ke Jin, Chao Chen, Hongxiang Wang, Lei Xu, Juxiang Chen   +13 more
wiley   +1 more source

Comprehensive analysis of faecal metagenomic and serum metabolism revealed the role of gut microbes and related metabolites in detecting colorectal lateral spreading tumours

Virulence
Colorectal lateral spreading tumours (LST), early-stage lesions of colorectal cancer (CRC), are associated with gut microbiota dysbiosis. However, the functional alterations in gut microbiota and their metabolic pathways remain inadequately understood ...
Hao Lin, Yudai Chen, Ming Zhou, Hongli Wang, Lichun Chen, Li Zheng, Zhixin Wang, Xiaoling Zheng, Shiyun Lu   +8 more
doaj   +1 more source

Modification‐Selective Inhibition of Succinate Dehydrogenase a Enables Tumor‐Restricted Mitochondrial Modulation

Advanced Science, EarlyView.
This work identifies acetylation‐dependent SDHA homeostasis as a determinant of tumor‐specific metabolic vulnerability. Guided by this mechanism, a modification‐selective inhibitor, ZPI‐3, selectively targets non‐acetylated SDHA, achieving tumor‐restricted SDH inhibition and effective bladder cancer control. Differential responses in clinical specimens
Kaikai Xu, Lulu Kong, Kebin Ye, Xinlu Bao, Haowen Liu, Ning Wang, Yongming Deng, Wei Wang, Shaohua Wei, Lin Zhou   +9 more
wiley   +1 more source

Biochemically Constrained Multi‐Omics Integration Reveals Protein–Metabolite Dependencies Across Diseases

Advanced Science, EarlyView.
ProMetNet introduces a biologically constrained deep learning framework for proteo‐metabolomic integration by embedding Reactome‐derived pathway topology into neural networks. It captures non‐linear molecular dependencies and pathway‐level metabolic reorganization, enabling interpretable discrimination.
Minghui Zhao, Na Zhou, Ruotong Liu, Xiaofei Li, Jian Li, Fuzhong Xue, Qingzhen Hou   +6 more
wiley   +1 more source

Emerging analytical techniques for lipid profiling in food products: insights into processing effects and quality control

Food Chemistry: X
Lipids are essential components of foods which include fatty acids, glycolipids, sphingolipids, sterols, vitamin D, isoprenoids, etc. It possesses bioactive properties that exhibit desirable impact on human health.
Deepika Kathuria, Sonal Aggarwal, Akanksha Negi, Riya Barthwal, Aroma Joshi, Narpinder Singh   +5 more
doaj   +1 more source

NMR metabolomic modeling of age and lifespan:A multicohort analysis [PDF]

Metabolomic age models have been proposed for the study of biological aging, however, they have not been widely validated. We aimed to assess the performance of newly developed and existing nuclear magnetic resonance spectroscopy (NMR) metabolomic age ...
Kivimäki, M, Marttila, S, Vineis, Paolo, Schmidt, F, Markozannes, G, Providencia, R, Tzoulaki, I, Manou, Maria, Järvelin, M-R, Palaniswamy, Saranya, Wong, A, Ben-Shlomo, Y, Munroe, Patricia B, Engmann, J, Järvelin, Marjo-Riitta, Gentry-Maharaj, Aleksandra, Raitakari, Olli, Chaturvedi, N, Markozannes, Georgios, Lehtimäki, T, Lau, Chung Ho E., Marttila, Saara, Robinson, O, Lehtimäki, Terho, Schmidt, Amand Floriaan, Munroe, Patricia B., Schmidt, Floriaan, Sebert, S, Ala-Korpela, M, Ben-Shlomo, Yoav, Menon, Usha, Menon, U, Kivimäki, Mika, Herzig, Karl Heinz, Manou, M, Kähönen, Mika, Järvelin, Marjo Riitta, Kähönen, M, Palaniswamy, S, Tzoulaki, Ioanna, Chaturvedi, Nish, Providencia, Rui, Sebert, Sylvain, Raitakari, O, Ala-Korpela, Mika, Hingorani, A, Lau, C-HE, Robinson, Oliver, Lau, Chung-Ho E, Herzig, K-H, Wong, Andrew, Vineis, P, Engmann, Jorgen, Herzig, Karl-Heinz, Munroe, PB, Gentry-Maharaj, A, Schmidt, AF, Hingorani, Aroon   +57 more
core   +1 more source

The Landscape of Long Non‐Coding RNAs Provides Insights Into the Domestication and Improvement of Pear Fruit

Advanced Science, EarlyView.
This study reveals that long non‐coding RNAs represent important regulatory components underlying pear domestication and improvement. Integrative multi‐omics analyses identify selected lncRNAs associated with fruit traits, while functional validation uncovers a lignin‐related lncRNA, lncRNA‐pys, that promotes lignin accumulation.
Bobo Song, Peilin Han, Jiaming Li, Xiaolong Li, Xiang Zhang, Jing Fan, Dongliang Liu, Jianfa Cai, Lingchao Zhang, Jun Wu   +9 more
wiley   +1 more source

Conditionally Significant eQTL and TWAS Analyses Identify MsRD26 as a Major Candidate Positive Regulator of Salt Tolerance in Medicago sativa L

Advanced Science, EarlyView.
Salt stress significantly impacts plant growth. Through population transcriptome, eQTL and TWAS analyses, we identified several candidate genes potentially associated with salt stress response. Functional assays suggested that some of these genes may contribute to salt tolerance.
Lin Chen, Yuqi Zhang, Xinyue Ma, Jinpeng Bi, Fei He, Li Zhao, Haiyue Lei, Zhengqin Xiao, Xue Wang, Tiejun Zhang, Ruicai Long, Junmei Kang, Qingchuan Yang   +12 more
wiley   +1 more source

MetaboSense: An Integrated Quantum Dot‐Mediated Aptamer Assay and Modular Microfluidic Platform for Continuous In‐Line Monitoring of Lung Metabolism During Ex Vivo Perfusion

Advanced Science, EarlyView.
MetaboSense is a first‐of‐its‐kind microfluidic platform enabling continuous, in‐line monitoring of glucose and lactate during ex vivo lung perfusion. Combining a quantum dot–mediated aptamer assay with mixing, depletion, and optofluidic detection modules, it achieves 60–s temporal resolution and shows strong agreement with standard blood gas analyzers,
Sanjana Srikant, Pouyan Keshavarz Motamed, Thomas Borrillo, Lielle Ronen, Gabriel Siebiger, Guillermo Garza, Hesam Abouali, Md Fahim Al Fattah, Ines Jaber, Dayan Ban, Marcelo Cypel, Mingyao Liu, Shaf Keshavjee, Andrew T. Sage, Mahla Poudineh   +14 more
wiley   +1 more source