Results 211 to 220 of about 184,184 (276)

Metabolomic signatures connect and mediate sedentary time-driven mortality risk in patients with cardiovascular disease. [PDF]

Front Sports Act Living
Zhu M, Ding K, Luo P, Peng X, Shi R, Wang R, Chen T.   +6 more
europepmc   +1 more source

Nanoparticle‐Mediated Immunometabolic‐Epigenetic Remodeling Enhances Schwann Cell‐Macrophage Interaction for Sciatic Nerve Regeneration

Advanced Science, EarlyView.
A biomimetic Prussian White nanoparticle (PW) is engineered to achieve long‐term local retention and orchestrate immunometabolic‐epigenetic remodeling for sciatic nerve regeneration. PW directly targets hexokinase 2 to suppress glycolysis, thereby elevating α‐ketoglutarate and driving Kdm4a/b‐mediated demethylation of H3K9me3.
Wenying Xu, Rongrong Wu, Zhicheng Liu, Hongyu Yan, Huan Zhang, Yuanyi Zheng, Xiaojun Cai   +6 more
wiley   +1 more source

Plasma metabolomic signatures in patients with multidrug-resistant bacterial sepsis. [PDF]

Metabolomics
Wang J, Luo G, Lv P, Li Q, Yu S, Chen Y, Yu L, Li K.   +7 more
europepmc   +1 more source

Integrating Human Intestinal Organoids into FDA'S New Approach Methodologies for Drug Discovery

Advanced Science, EarlyView.
Illustration summarizes how human intestinal organoids (HIOs) are becoming transformative in preclinical research. Preclinical drug discovery pipelines often rely on animal models for ADMET studies, even though interspecies ADME gaps, poor external validity, and high attrition rates are common.
Debarun Patra, Ibrahim M. Sayed, Souhrid Mukherjee, Honit Piplani, Aida Habtezion, Michael J. Rosen, Jospeh C. Wu   +6 more
wiley   +1 more source

Metabolomic and proteomic signatures of gestational diabetes predicting long-term risk of type 2 diabetes: a prospective cohort study in the UK Biobank

Torres-Martos A, Michalopoulou M, Jurado-Fasoli L, Jebb SA, Carter J, Carvalho C, Aguilera CM, Astbury N, Piernas C.   +8 more
europepmc   +1 more source

Identification of metabolic signatures of immune response following mRNA and inactivated vaccines against COVID-19: a systematic review. [PDF]

Front Immunol
Wasilewski A, Serrafi A.
europepmc   +1 more source

A “Hot Spring” Mimetic Aerogel Loaded with Multiple Amino Acids Modulates the Chronic Inflammatory Microenvironment Through Metabolic Reprogramming

Advanced Science, EarlyView.
The SrCuSi4O₁₀ bioceramic particles mimic the effects of hot spring therapy by increasing the local wound temperature, which enhances the absorption of amino acids and stimulates cell metabolism. The amino acid uptake supports cellular glutathione redox reactions, helping to mitigate oxidative stress.
Bo Li, Dandan Jin, Fei Li, Jianliang Shen, Jiang Chang, Chen Yang, Shixuan Chen, Yi Zhang   +7 more
wiley   +1 more source

Exploring translational relevance of baseline and longitudinal metabolic profiling in the blood of ovarian cancer patients. [PDF]

NPJ Precis Oncol
Funk AM, Freitag L, Schwarz FM, Link T, Jonas S, Wimberger P, Brieske M, Klimova A, Chavakis T, Mirtschink P, Kuhlmann JD.   +10 more
europepmc   +1 more source

Potential Nutraceuticals in Mussel Waste [PDF]

, 2012
Neil, D.M., Thompson, J.
core  

Polydopamine‐Encapsulated Probiotics Restore Gut Homeostasis and Reinstate Macrophage Efferocytosis in Systemic Lupus Erythematosus

Advanced Science, EarlyView.
Polydopamine‐encapsulated probiotics restore gut homeostasis and reinstate macrophage efferocytosis, thereby reestablishing immune tolerance and mitigating systemic autoimmunity, highlighting a bioengineered microbiota‐based therapeutic strategy for SLE.
Ruimiao Wu, Mei Liu, Changxing Gao, Cheng Zhao, Feijie Zhao, Shuqing Dong, Bo Zhang, Qianmei Liu, Wenqian Zhang, Ming Zhao, Qianjin Lu   +10 more
wiley   +1 more source