Results 11 to 20 of about 297,367 (349)
Cell Metabolism, 2007 Metabolomics is the systematic identification and quantitation of all metabolites in a given organism or biological sample. The enhanced resolution provided by nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS), along with powerful chemometric software, allows the simultaneous determination and comparison of thousands of chemical ...
Idle, Jeffrey R., Gonzalez, Frank J.
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Metabolites, 2020 From an animal health perspective, relatively little is known about the typical or healthy ranges of concentrations for many metabolites in bovine biofluids and tissues. Here, we describe the results of a comprehensive, quantitative metabolomic characterization of six bovine biofluids and tissues, including serum, ruminal fluid, liver, Longissimus ...
Aidin Foroutan +8 more
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Metabolites, 2019 Metabolomics is the systematic study of the small-molecule profiles of biological samples produced by specific cellular processes. The high-throughput technologies used in metabolomic investigations generate datasets where variables are strongly correlated and redundancy is present in the data.
Matteo Stocchero +5 more
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Xenobiotic Metabolomics: Major Impact on the Metabolome [PDF]
Annual Review of Pharmacology and Toxicology, 2012 Xenobiotics are encountered by humans on a daily basis and include drugs, environmental pollutants, cosmetics, and even components of the diet. These chemicals undergo metabolism and detoxication to produce numerous metabolites, some of which have the potential to cause unintended effects such as toxicity.
Caroline H, Johnson +3 more
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Cancer Metabolomics and the Human Metabolome Database [PDF]
Metabolites, 2016 The application of metabolomics towards cancer research has led to a renewed appreciation of metabolism in cancer development and progression. It has also led to the discovery of metabolite cancer biomarkers and the identification of a number of novel cancer causing metabolites.
David S. Wishart +3 more
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Computational Metabolomics: A Framework for the Million Metabolome [PDF]
Chemical Research in Toxicology, 2016 "Sola dosis facit venenum." These words of Paracelsus, "the dose makes the poison", can lead to a cavalier attitude concerning potential toxicities of the vast array of low abundance environmental chemicals to which humans are exposed. Exposome research teaches that 80-85% of human disease is linked to environmental exposures.
Karan, Uppal +5 more
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Metabolomics in cancer research and emerging applications in clinical oncology
Ca, 2021 Cancer has myriad effects on metabolism that include both rewiring of intracellular metabolism to enable cancer cells to proliferate inappropriately and adapt to the tumor microenvironment, and changes in normal tissue metabolism.
D. R. Schmidt +5 more
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BMC Plant Biology, 2023 Background Puccinia striiformis f. sp. tritici (Pst) is an economically devasting disease that is prominent in cereal crops such as wheat (Triticum aestivum). The fungal pathogen can cause approximately 30–70% losses in crop productivity and yields.
Manamele Dannies Mashabela +5 more
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Cardiovascular Metabolomics [PDF]
Circulation Research, 2018 Disturbances in cardiac metabolism underlie most cardiovascular diseases. Metabolomics, one of the newer omics technologies, has emerged as a powerful tool for defining changes in both global and cardiac-specific metabolism that occur across a spectrum of cardiovascular disease states.
Robert W, McGarrah +4 more
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Serum-Urine Matched Metabolomics for Predicting Progression of Henoch-Schonlein Purpura Nephritis
Frontiers in Medicine, 2021 Henoch-Schonlein purpura nephritis (HSPN) is a common glomerulonephritis secondary to Henoch-Schonlein purpura (HSP) that affects systemic metabolism. Currently, there is a rarity of biomarkers to predict the progression of HSPN.
Qian Zhang +7 more
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