Results 1 to 10 of about 7,923 (211)

Progress in Metabonomics of Type 2 Diabetes Mellitus

Molecules, 2018
With the improvement of living standards and a change in lifestyle, the incidence of type 2 diabetes mellitus (T2DM) is increasing. Its etiology is too complex to be completely understand yet.
Chunguo Wang, Liyaqi Li, Zhao Baosheng
exaly   +4 more sources

Diagnostic Value of Homocysteine Metabolic Pathway in Coronary Atherosclerosis: A Study on Reference Intervals and Risk Prediction [PDF]

International Journal of General Medicine
Shen Li,1 Furong Zhao,2 Mo Hong,3,4 Yanru Zhu,3 Hongzhi Sun2 1Central Laboratory, Central Hospital of Dalian University of Technology, Dalian, People’s Republic of China; 2Liaoning Provincial Key Laboratory of Clinical Oncology Metabonomics, First ...
Li S, Zhao F, Hong M, Zhu Y, Sun H
doaj   +2 more sources

Optimized integration of metabolomics and lipidomics reveals brain region-specific changes of oxidative stress and neuroinflammation in type 1 diabetic mice with cognitive decline

Journal of Advanced Research, 2023
Introduction: Type 1 diabetes (T1D) causes cognitive decline and has been associated with brain metabolic disorders, but its potential molecular mechanisms remain unclear.
Fen Xiong, Kaiyan Gong, Hangying Xu, Yingxin Tu, Jiahui Lu, Yiyang Zhou, Wenting He, Wenqing Li, Chen Li, Liangcai Zhao, Hongchang Gao, Hong Zheng   +11 more
doaj   +1 more source

Fibroblast Growth Factor 21 Modulates Microglial Polarization That Attenuates Neurodegeneration in Mice and Cellular Models of Parkinson's Disease

Frontiers in Aging Neuroscience, 2021
Microglial polarization and the subsequent neuroinflammatory response were identified as key contributors to the progress of Parkinson's disease (PD).
Changwei Yang, Changwei Yang, Wuqiong Wang, Pengxi Deng, Chen Li, Liangcai Zhao, Hongchang Gao   +6 more
doaj   +1 more source

Depletion of acetate-producing bacteria from the gut microbiota facilitates cognitive impairment through the gut-brain neural mechanism in diabetic mice

Microbiome, 2021
Background Modification of the gut microbiota has been reported to reduce the incidence of type 1 diabetes mellitus (T1D). We hypothesized that the gut microbiota shifts might also have an effect on cognitive functions in T1D.
Hong Zheng, Pengtao Xu, Qiaoying Jiang, Qingqing Xu, Yafei Zheng, Junjie Yan, Hui Ji, Jie Ning, Xi Zhang, Chen Li, Limin Zhang, Yuping Li, Xiaokui Li, Weihong Song, Hongchang Gao   +14 more
doaj   +1 more source

Research progress on metabonomics in primary biliary cholangitis [PDF]

Xin yixue, 2023
Primary biliary cholangitis （PBC） is a disease with unclear etiology and pathogenesis. In recent years，it has become a hot topic to identify the potential pathogenesis and therapeutic targets of PBC by studying the changes of metabolic substances in PBC ...
Bu Jinyang, Yu Xiao, Miao Hongyu, Pan Jielu, Zhang Haiyan, Xing Lianjun
doaj   +1 more source

Application of Metabonomics in Substance Abuse Toxicology Research

Fayixue Zazhi, 2022
Abstrct: Metabonomics is a relative discipline that develops after genomics and proteomics, and it is an important component of systems biology. It uses high-throughput and high-sensitivity instruments to perform qualitative and quantitative analysis of ...
YAN Xiu-ying, XIANG Ping, YU Zhi-guo, YAN Hui   +3 more
doaj   +1 more source

Sex-specific metabolic alterations in the type 1 diabetic brain of mice revealed by an integrated method of metabolomics and mixed-model

Computational and Structural Biotechnology Journal, 2020
Type 1 diabetes (T1D) can cause brain region-specific metabolic disorders, but whether gender influences T1D-related brain metabolic changes is rarely reported.
Qiaoying Jiang, Hangying Xu, Junjie Yan, Qingqing Xu, Yafei Zheng, Chen Li, Liangcai Zhao, Hongchang Gao, Hong Zheng   +8 more
doaj   +1 more source

Research progress of metabonomics of blood endogenous small molecules in depression

European Psychiatry, 2021
Introduction Depression (MDD) is a serious mental illness, which greatly affects the quality of life of patients. Nowadays, the clinical diagnosis of MDD lacks sufficient objective basis, and the effect of drug treatment is unsatisfactory.
Y. Zhang, J. Ding, X. Cui
doaj   +1 more source

Nutritional Metabonomics: An Approach to Promote Personalized Health and Wellness

CHIMIA, 2011
Nutritional research has emerged in the last century from the study of nutrients as a means of nourishment to the general population to the quest for wellness improvement through specific food components.
Sebastiano Collino, François-Pierre J. Martin, Sunil Kochhar, Serge Rezzi   +3 more
doaj   +1 more source