Results 31 to 40 of about 7,923 (211)

Analysis of subgingival micro-organisms based on multi-omics and Treg/Th17 balance in type 2 diabetes with/without periodontitis

open access: yesFrontiers in Microbiology, 2022
Type 2 diabetes mellitus (T2DM) and periodontitis are common and interrelated diseases, resulting in altered host response microbiota. The subgingival micro-organisms play a key role in periodontitis pathogenesis.
Lanlan Jiang   +9 more
doaj   +1 more source

Based on Plasma Metabonomics and Network Pharmacology Exploring the Therapeutic Mechanism of Gynura procumbens on Type 2 Diabetes

open access: yesFrontiers in Pharmacology, 2021
Gynura procumbens (GP) is a perennial herbal medicine and food homologous plant, which has been reported to have a good hypoglycemic effect. However, its active components and underlying mechanism of action are not clear.
Wenjing Guo   +7 more
doaj   +1 more source

Deciphering the Underlying Mechanisms of Formula Le-Cao-Shi Against Liver Injuries by Integrating Network Pharmacology, Metabonomics, and Experimental Validation

open access: yesFrontiers in Pharmacology, 2022
Le-Cao-Shi (LCS) has long been used as a folk traditional Chinese medicine formula against liver injuries, whereas its pharmacological mechanisms remain elusive. Our study aims to investigate the underlying mechanism of LCS in treating liver injuries via
Qing Zhao   +15 more
doaj   +1 more source

Metabonomics and intensive care

open access: yesCritical Care, 2016
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency medicine 2016. Other selected articles can be found online at http://www.biomedcentral.com/collections/annualupdate2016. Further information about the Annual Update in Intensive Care and Emergency Medicine is available from http://www.springer.com/series ...
Antcliffe, D, Gordon, AC
openaire   +4 more sources

Transcriptome, proteomics and metabonomics in dermatology

open access: yesPifu-xingbing zhenliaoxue zazhi, 2022
With the continuous emergence and breakthrough of new technologies and methods, the omics research has accelerated the development of high-throughput quantification.
Qian LI, Xibao ZHANG, Jingyao LIANG
doaj   +1 more source

Uncoupling the Mitogenic and Metabolic Functions of FGF1 by Tuning FGF1-FGF Receptor Dimer Stability

open access: yesCell Reports, 2017
Lysine acetylation is involved in various biological processes and is considered a key reversible post-translational modification in the regulation of gene expression, enzyme activity, and subcellular localization. This post-translational modification is
Zhifeng Huang   +14 more
doaj   +1 more source

DosR’s multifaceted role on Mycobacterium bovis BCG revealed through multi-omics

open access: yesFrontiers in Cellular and Infection Microbiology, 2023
Mycobacterium tuberculosis (Mtb) is an intracellular bacterium that causes a highly contagious and potentially lethal tuberculosis (TB) in humans. It can maintain a dormant TB infection within the host.
Yingying Cui   +8 more
doaj   +1 more source

Metabolic Disturbances in the Striatum and Substantia Nigra in the Onset and Progression of MPTP-Induced Parkinsonism Model

open access: yesFrontiers in Neuroscience, 2018
Metabolic confusion has been linked to the pathogenesis of Parkinson's disease (PD), while the dynamic changes associated with the onset and progression of PD remain unclear. Herein, dynamic changes in metabolites were detected from the initiation to the
Yi Lu   +11 more
doaj   +1 more source

Comparative Analysis of Metabolic Differences of Jersey Cattle in Different High-Altitude Areas

open access: yesFrontiers in Veterinary Science, 2021
In high-altitude area, hypoxia is a serious stress for humans and other animals, disrupting oxygen homeostasis and thus affecting tissue metabolism. Up to now, there are few reports on the metabolic changes of dairy cows at different altitudes.
Zhiwei Kong   +7 more
doaj   +1 more source

Essential Oils From the Fruit of Amomum villosum Lour. Alleviate LPS‐Induced Neuroinflammation by Repressing PI3K‐Akt and MAPK Signaling Pathways

open access: yesPhytotherapy Research, EarlyView.
Amomum villosum essential oil (AVEO) alleviates LPS‐induced neuroinflammation and cognitive and behavioral dysfunction by suppressing PI3K‐Akt and MAPK signaling pathways, modulating inflammatory responses, and restoring metabolic homeostasis, thereby exerting neuroprotective effects. ABSTRACT Amomum villosum Lour.
Hongjin Wang   +11 more
wiley   +1 more source

Home - About - Disclaimer - Privacy