Results 11 to 20 of about 7,923 (211)

Metabonomics in gastroenterology and hepatology [PDF]

International Journal of Molecular Sciences, 2019
Attempts have been made to reveal the true nature of a range of puzzling diseases within gastroenterology and hepatology using different kinds of omics, namely genomics, transcriptomics, proteomics, and metabonomics [...
Ole Haagen Nielsen, Bjerrum, Jacob Tveiten, Jacob Tveiten Bjerrum, Nielsen, Ole Haagen   +3 more
core   +5 more sources

Intermittent Fasting Restores Cardiac Lipid Homeostasis in Diabetic Cardiomyopathy in Association With Akkermansia Muciniphila and 1‐methyl‐L‐histidine

Advanced Science
Diabetic cardiomyopathy (DCM) is a major cardiovascular complication of diabetes with limited effective interventions. Using a streptozotocin‐induced insulin‐deficient, type 1 diabetes‐like DCM mouse model, we show that intermittent fasting (IF) improves
Kaiyuan Jiang, Fen Xiong, Yiwen Peng, Lingfei Meng, Xinran Wang, Yingruo Xu, Tian Tang, Hongchang Gao   +7 more
doaj   +2 more sources

HPLC-MS-Based Metabonomics Reveals Disordered Lipid Metabolism in Patients with Metabolic Syndrome

Journal of Analytical Science and Technology, 2011
Ultra-high performance liquid chromatography/ quadrupole time of flight mass spectrometry-based metabonomics platform was employed to profile the plasma metabolites of patients with metabolic syndrome and the healthy controls. Data analysis revealed lots
Xinjie Zhao, Yan Chu, Shili Chen, Peng Gao, Li Zhang, Libin Zhan, Guowang Xu   +6 more
doaj   +1 more source

Metabonomics window into plateau hypoxia [PDF]

Journal of International Medical Research, 2019
Oxygen deficiency in the plateau environment weakens aerobic metabolism and reduces the energy supply, leading to high-altitude diseases including decreased circulatory function, decreased nutrient and energy supply to tissues and organs, and decreased ...
Yue Chang, Wen Zhang, Kai Chen, Zhenguo Wang, Shihai Xia, Hai Li   +5 more
doaj   +3 more sources

Network Pharmacology Combined With Metabonomics and Transcriptomics Reveals the Mechanism of <i>Rubus</i> Chingii Hu in Alleviating Nephrotoxicity Caused by Tripterygium Glycosides Tablet. [PDF]

Food Sci Nutr
Flow chart of RCH to improve TGT‐induced nephrotoxicity. ABSTRACT Researches on Tripterygium glycosides tablets (TGT) often overlook renal toxicity from prolonged use. Rubus chingii Hu (RCH) is beneficial to kidney health and has an unclear role in reducing nephrotoxicity.
Zhang C, Zhang Z, Zhou T, Zhang L.
europepmc   +2 more sources

Metabolomics and Mechanistic Approaches Reveal the Synergistic and Attenuating of Rubus chingii Hu on Tripterygium Glycoside Tablets in the Treatment of Rheumatoid Arthritis. [PDF]

Chem Biodivers
Experimental flow chart of the attenuating and synergistic effects of RCH on TGTs in the treatment of rheumatoid arthritis. ABSTRACT Tripterygium Glycoside Tablets (TGTs) are primary drugs for rheumatoid arthritis (RA) but pose a risk of nephrotoxicity. Rubus chingii Hu (RCH) may enhance kidney function.
Zhang C, Zhang Z, Yan F, Zhang L.
europepmc   +2 more sources

Clinical and Epidemiological Metabonomics [PDF]

BioMed Research International, 2011
Metabonomics is an omics approach to identify and monitor metabolic characteristics, changes, and phenotypes with respect to various synergetic factors such as environment, life style, diet, and potential pathophysiological processes. Recently, metabonomics has also opened up a possibility for functional genomics in large genome-wide studies.
Ala-Korpela, Mika, Salomaa, Veikko, Kvalheim, Olav M.   +2 more
openaire   +2 more sources

Txnip/PDK4-Mediated Hyperdependence on Fatty-Acid Oxidation Amplifies Susceptibility of Diabetic Myocardium to Ischemia-Reperfusion Damage. [PDF]

J Diabetes
We show for the first time that the cardiomyocyte subtype (C6 cardiomyocyte) is a cardiomyocyte characterized by myocardial contraction, and the reduction of its number and metabolic heterogeneity is the basis of myocardial ischemia–reperfusion injury in diabetes.
Zeng Z, Shi W, He Y, Wang Y, Pu C, Tan J, Guo H, Ma H.   +7 more
europepmc   +2 more sources

Metabolic Signatures of Lung Cancer in Biofluids: NMR-Based Metabonomics of Blood Plasma [PDF]

, 2011
In this work, the variations in the metabolic profile of blood plasma from lung cancer patients and healthy controls were investigated through NMR-based metabonomics, to assess the potential of this approach for lung cancer screening and diagnosis.
Joana Carrola, Brian J. Goodfellow, Carreira, Isabel M., Goodfellow, Brian J., Rocha, Cláudia M., Gil, Ana M., Carvalho, Lina, Cláudia M. Rocha, António S. Barros, Lina Carvalho, Barros, António S., Ana Gomes, Bernardo, Joao, Carrola, Joana, Sousa, Vitor, Ana M. Gil, João Bernardo, Vitor Sousa, Gomes, Ana, Iola F. Duarte, Isabel M. Carreira, Duarte, Iola F.   +21 more
core   +1 more source

Chemometrics in Metabonomics

Journal of Proteome Research, 2006
We provide an overview of how the underlying philosophy of chemometrics is integrated throughout metabonomic studies. Four steps are demonstrated: (1) definition of the aim, (2) selection of objects, (3) sample preparation and characterization, and (4) evaluation of the collected data.
Johan, Trygg, Elaine, Holmes, Torbjörn, Lundstedt   +2 more
openaire   +2 more sources