Results 21 to 30 of about 7,923 (211)

Metabonomics fingerprint of the isolated and perfused liver [PDF]

, 2010
Metabonomics fingerprint of the isolated and perfused ...
Tagliatti, Vanessa, Colet, Jean-Marie, Conotte, Raphael   +2 more
core   +4 more sources

Antibiotic Exposure Has Sex-Dependent Effects on the Gut Microbiota and Metabolism of Short-Chain Fatty Acids and Amino Acids in Mice

mSystems, 2019
The gut microbiota has the capability to regulate homeostasis of the host metabolism. Since antibiotic exposure can adversely affect the microbiome, we hypothesized that antibiotic effects on the gut microbiota and host metabolism are sex dependent.
Hongchang Gao, Qi Shu, Jiuxia Chen, Kai Fan, Pengtao Xu, Qi Zhou, Chen Li, Hong Zheng   +7 more
doaj   +1 more source

Comprehensive metabolomic and lipidomic alterations in response to heat stress during seed germination and seedling growth of Arabidopsis

Frontiers in Plant Science, 2023
Temperature affects seed germination and seedling growth, which is a critical and complex stage in plant life cycle. However, comprehensive metabolic basis on temperature implicating seed germination and seedling growth remains less known.
Wenjuan Qian, Yuxuan Zhu, Qinsheng Chen, Shuaiyao Wang, Longlong Chen, Ting Liu, Huiru Tang, Hongyan Yao   +7 more
doaj   +1 more source

High Glucose-Induced Cardiomyocyte Death May Be Linked to Unbalanced Branched-Chain Amino Acids and Energy Metabolism

Molecules, 2018
High glucose-induced cardiomyocyte death is a common symptom in advanced-stage diabetic patients, while its metabolic mechanism is still poorly understood.
Xi Zhang, Qiuting Lin, Jiuxia Chen, Tingting Wei, Chen Li, Liangcai Zhao, Hongchang Gao, Hong Zheng   +7 more
doaj   +1 more source

Treatment of wild-type mice with 2,3-butanediol, a urinary biomarker of Fmo5−/− mice, decreases plasma cholesterol and epididymal fat deposition

Frontiers in Physiology, 2022
We previously showed that Fmo5−/− mice exhibit a lean phenotype and slower metabolic ageing. Their characteristics include lower plasma glucose and cholesterol, greater glucose tolerance and insulin sensitivity, and a reduction in age-related weight gain
Sunil Veeravalli, Dorsa Varshavi, Flora H. Scott, Dorna Varshavi, Frank S. Pullen, Kirill Veselkov, Ian R. Phillips, Ian R. Phillips, Jeremy R. Everett, Elizabeth A. Shephard   +9 more
doaj   +1 more source

Metabonomics in Diabetes Research [PDF]

Journal of Diabetes Science and Technology, 2007
Metabonomics has been defined as “quantitative measurement of the dynamic multiparametric metabolic response of living systems to pathophysiological stimuli or genetic modification” and can provide information on disease processes, drug toxicity, and gene function.
Johan H, Faber, Daniel, Malmodin, Henrik, Toft, Anthony D, Maher, Derek, Crockford, Elaine, Holmes, Jeremy K, Nicholson, Marc E, Dumas, Dorrit, Baunsgaard   +8 more
openaire   +2 more sources

An NMR-Based Metabolomic Approach to Unravel the Preventive Effect of Water-Soluble Extract from Dendrobium officinale Kimura & Migo on Streptozotocin-Induced Diabetes in Mice

Molecules, 2017
Dendrobium officinale Kimura & Migo (D. officinale) is a precious herbal medicine. In this study, we investigated metabolic mechanism underlying the effect of D. officinale water extract (DOWE) on diabetes prevention in mice after streptozotocin (STZ)
Hong Zheng, Linlin Pan, Pengtao Xu, Jianjun Zhu, Ruohan Wang, Wenzong Zhu, Yongsheng Hu, Hongchang Gao   +7 more
doaj   +1 more source

Beneficial metabolic effects of 2',3',5'-tri-acetyl-N6- (3-hydroxylaniline) adenosine in the liver and plasma of hyperlipidemic hamsters. [PDF]

PLoS ONE, 2012
BACKGROUND: Pharmaceutical research of hyperlipidemia has been commonly pursued using traditional approaches. However, unbiased metabonomics attempts to explore the metabolic signature of hyperlipidemia in a high-throughput manner to understand ...
Yang Sun, Zeqin Lian, Chunying Jiang, Yinghong Wang, Haibo Zhu   +4 more
doaj   +1 more source

Periodontitis relates to benign prostatic hyperplasia via the gut microbiota and fecal metabolome

Frontiers in Microbiology, 2023
ObjectivesPeriodontitis is associated with benign prostatic hyperplasia (BPH), whether it related to gut floramicrobiota and metabonomics is unclear.MethodsWe established ligature-induced periodontitis (EP), testosterone-induced BPH, and composite rat ...
Xing-Pei Guo, Xing-Pei Guo, Jun Yang, Lan Wu, Lan Wu, Cheng Fang, Jia-Min Gu, Jia-Min Gu, Fei Li, Fei Li, Han-Song Liu, Lu-Yao Li, Lu-Yao Li, Shuang-Ying Wang   +13 more
doaj   +1 more source

HSPB1 Regulates Autophagy and Apoptosis in Vascular Smooth Muscle Cells in Arteriosclerosis Obliterans

Cardiovascular Therapeutics, 2022
Objective. Small heat shock protein-1 (HSPB1) is a small heat shock protein that participates in many cellular processes and alleviates stress-induced cell injury.
Keqin Chen, Changmiao Hou, Lei Xu, Hanwu Peng, Chaogui He, Jing Liu, Guoqing Wang, Shaoshuai Huang, Xiehong Liu   +8 more
doaj   +1 more source