Results 51 to 60 of about 7,923 (211)

Tissue-Targeted Metabonomics: Metabolic Profiling by Microdialysis and NMR Spectroscopy [PDF]

, 2008
This research offers an alternative approach to the study of tissue-specific metabolism by metabonomics, called tissue-targeted metabonomics. Microdialysis sampling was used to sample small endogenous metabolites in tissue extracellular fluid.
Price, Kristin Elizabeth
core   +1 more source

Research advances of amino acid metabonomics in renal diseases

Linchuang shenzangbing zazhi
Kidney is a major metabolic organ of human body. Amino acids are not only the basic components of protein， but also important metabolites in human body. Recent researches have demonstrated that amino acids play an important role in the pathophysiological
Bin Xie, Xiao-hong Ren, Ze-xuan Li, GaoYi-wen, Xiao-jun Ren   +4 more
doaj   +1 more source

Effects of ketogenic and low‐carbohydrate diet on glucose and weight control in type 2 diabetes mellitus patients along with metabolome change

Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.
Both the low‐carbohydrate diet (LCD) and the ketogenic diet (KD) positively affect body weight and glucose metabolism in type 2 diabetes. Metabolomic signatures sensitively reflect each diet and correlate with clinical improvements – distinct metabolite associations with glycated haemoglobin and weight were identified for LCD versus KD.
Yao Wang, Haozhe He, Zhenjing Lyu, Yeyang Wang, Li Chen, Junbin Liang, Cong Lin, Huanhuan Wang, Shiping Zhang, Gugen Xu, Junzhang Tian, Kejing Zeng   +11 more
wiley   +1 more source

Urinary 1H-NMR metabonomics study on intervention effects of soya milk in Africans

, 2011
Metabonomics is an important tool in understanding the toxicological or therapeutic effects of interventions by analysing metabolic profiles and interpreting complex multi-dimensional spectroscopic/spectrometric data using multivariate data analysis. The
Oluwole Familoni, John Crowder, Olayinka Asekun, S. W. Annie Bligh, Olumuyiwa L. Ogegbo, Ogegbo, O., Dissanyake, W., Wimal Dissanyake, Christopher J. Branford-White, Branford-White, C.J., Crowder, J., Asekun, O., Familoni, O., Bligh, S.W.A.   +13 more
core   +1 more source

GC-MS metabonomics analysis for USA300 in the presence of uracil.xlsx

, 2023
GC-MS metabonomics analysis for USA300 in the presence of uracil.
Su (10814763)
core   +1 more source

Endogenous CD155 drives metabolic reprogramming via PI3K/AKT/HIF‐1α‐glycolysis axis to mediate anti‐PD‐1 resistance in non‐small cell lung cancer

Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.
CD155 is identified as a key driver of anti‐PD‐1 resistance in NSCLC. CD155 promotes tumour glycolysis and malignant progression via the PI3K/AKT/HIF‐1α signalling axis. AAV9_shCD155 combined with anti‐PD‐1 markedly inhibits tumour growth and promotes immune infiltration. Abstract Objective Anti‐PD‐1 therapy resistance remains a critical barrier in non‐
Wei‐Guang Du, Xi‐Yang Tang, Yu‐Long Zhou, Run‐Ze Zhang, Zhi‐Bo Feng, Meng‐Chao Li, Jun‐Yang Pan, Yao Lv, Xiao‐Liang Xu, Xiao‐Long Yan, Nan Ma, Jin‐Bo Zhao   +11 more
wiley   +1 more source

Composition Differences of Procyanidins in Chestnut Shell and Pellicle before and after Digestion Based on in Vitro Digestion Model

Shipin gongye ke-ji, 2022
In this study, the composition changes of procyanidins in chestnut shell and pellicle after simulated digestion were analyzed by extensive targeted metabolomics based on ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS).
Haonan LI, Xiaomin HUANG, Yihe FANG, Wenxin XIAO, Ziqin ZHANG, Fang YANG   +5 more
doaj   +1 more source

The Metabonomic Signature of Celiac Disease

Journal of Proteome Research, 2008
Celiac disease (CD) is a multifactorial disorder involving genetic and environmental factors, thus, having great potential impact on metabolism. This study aims at defining the metabolic signature of CD through Nuclear Magnetic Resonance (NMR) of urine and serum samples of CD patients.
Ivano Bertini, CALABRO', ANTONINO SALVATORE, Valeria De Carli, LUCHINAT, CLAUDIO, Stefano Nepi, PORFIRIO, BERARDINO, RENZI, DANIELA, Edoardo Saccenti, TENORI, LEONARDO   +8 more
openaire   +3 more sources

The gut microbiome organ

iMeta, Volume 5, Issue 4, August 2026.
The gut microbiome can be conceptualized as a distributed organ‐like functional system with spatially structured organization, broad biochemical capacity, and continuous bidirectional communication with the host. By transforming dietary, host‐derived, and environmental substrates into bioactive metabolites with endocrine‐like, immunomodulatory, and ...
Yang Bi, Weibin Song, Maria Glymenaki, Jie Hu, Xiru Li, Heng Huang, Yousong Peng, Shuaishuai Ni, Ornuma Haonon, Zhu Liu, Krai Daowtak, Xiaotao Shen, Huadong Peng, Jutarop Phetcharaburanin, Huiru Tang, Yulan Wang, Jia V. Li, Mizu Jiang, Nick Powell, Victor W. Zhong, Elaine Holmes, Yunlei Xianyu, Zhigang Liu   +22 more
wiley   +1 more source

Silencing arachidonate 15-lipoxygenase alleviates hypoxia-induced cognitive impairment through the mediation of phospholipase A2 group IVC–LPC18:0 to suppress ferroptosis

Molecular Biomedicine
Hypoxic injury is a major contributor to cognitive impairment (CI), but the lipid metabolic mechanisms linking hypoxia (HYP) to hippocampal ferroptosis remain understood.
Zhen Li, Jie Gao, Jun Fu, Xi Zhang, Yiyang Zhou, Chen Li, Jutaek Nam, Hongchang Gao   +7 more
doaj   +1 more source