Metabotropic glutamate 2/3 receptors and epigenetic modifications in psychotic disorders: a review [PDF]
, 2016 Schizophrenia and Bipolar Disorder are chronic psychiatric disorders, both considered as "major psychosis"; they are thought to share some pathogenetic factors involving a dysfunctional gene x environment interaction.
Grayson, Danis R +4 more
core +2 more sources
Phased Treatment Strategies for Cerebral Ischemia Based on Glutamate Receptors
Frontiers in Cellular Neuroscience, 2019 Extracellular glutamate accumulation following cerebral ischemia leads to overactivation of glutamate receptors, thereby resulting in intracellular Ca2+ overload and excitotoxic neuronal injury. Multiple attempts have been made to counteract such effects
Yongjun Sun +8 more
doaj +1 more source
Metabotropic Glutamate Receptors and Epileptogenesis
Epilepsy Currents, 2002 Activation of metabotropic glutamate receptors (mGluRs) often produces long-lasting effects on the excitability of cortical neurons. For example, mGluR stimulation induces long-term potentiation or depression of excitatory synaptic transmission in the hippocampus.
Robert K. S. Wong +2 more
openaire +3 more sources
Conformational pathway provides unique sensitivity to a synaptic mGluR
Nature Communications, 2019 Metabotropic glutamate receptors (mGluRs) are dimeric G-protein–coupled receptors that operate at neural synapses. Here authors use FRET assays in live cells to monitor mGluR2/7’s activation and reveal how heterodimerization can alter the glutamate ...
Chris H. Habrian +7 more
doaj +1 more source
Cell Death and Disease, 2021 Glioblastoma (GBM), the most malignant tumor of the central nervous system, is marked by its dynamic response to microenvironmental niches. In particular, this cellular plasticity contributes to the development of an immediate resistance during tumor ...
Julian P. Maier +17 more
doaj +1 more source
A mechanistic overview of approaches for the treatment of psychostimulant dependence
Frontiers in Pharmacology, 2022 Psychostimulant use disorder is a major health issue around the world with enormous individual, family-related and societal consequences, yet there are no effective pharmacological treatments available.
Kathrine Louise Jensen +2 more
doaj +1 more source
Non-canonical Mechanisms of Presynaptic Kainate Receptors Controlling Glutamate Release
Frontiers in Molecular Neuroscience, 2018 A metabotropic modus operandi for kainate receptors (KARs) was first discovered in 1998 modulating GABA release. These receptors have been also found to modulate glutamate release at different synapses in several brain regions. Mechanistically, a general
José V. Negrete-Díaz +4 more
doaj +1 more source
Targeting mGlu5 metabotropic glutamate receptors in the treatment of cognitive dysfunction in a mouse model of phenylketonuria [PDF]
, 2018 We studied group-I metabotropic glutamate (mGlu) receptors in Pah(enu2) (ENU2) mice, which mimic the genetics and neurobiology of human phenylketonuria (PKU), a metabolic disorder characterized, if untreated, by autism, and intellectual disability (ID ...
Battaglia, Giuseppe +12 more
core +2 more sources
Mechanisms associated with activation of intracellular metabotropic glutamate receptor, mGluR5 [PDF]
, 2016 The group 1 metabotropic glutamate receptor, mGluR5, is found on the cell surface as well as on intracellular membranes where it can mediate both overlapping and unique signaling effects.
Jong, Yuh-Jiin I, O\u27Malley, Karen L
core +2 more sources
Ionotropic glutamate receptors and their implications in cancer and cancer therapeutics
Biomedical and Biotechnology Research Journal, 2021 Glutamine, an excitatory neurotransmitter, is necessary for physiological as well as pathological processes. Other than neuronal disorders and/or cancers, glutamate receptors have also been associated with an array of other malignancies. The metabotropic
Shree Goyal +2 more
doaj +1 more source