Results 91 to 100 of about 58,396 (229)

Pharmacokinetics of Aztreonam–Avibactam After Single‐ and Multiple‐Dose Administration: A Phase 1, Open‐Label Study in Healthy Chinese Participants and Ethnic Comparison with Non‐Chinese Participants

Clinical Pharmacology in Drug Development, Volume 15, Issue 2, February 2026.
ABSTRACT Combined treatment with aztreonam (an established intravenous antibiotic) and avibactam (a β‐lactamase inhibitor) has the potential to address the unmet need for safe and effective agents to combat infections caused by Gram‐negative bacteria producing metallo β‐lactamases (MBLs).
Jingjing Wang, Jinjie He, Jufang Wu, Jing Zhang, Ying Ma, Xiaoqing Ren, Hua Wei, Chunye Zhang, Hua Zhu, Susan R. Raber, Shuangchen Cong   +10 more
wiley   +1 more source

Differential Binding of Co(II) and Zn(II) to Metallo-β-Lactamase Bla2 from \u3cem\u3eBacillus anthracis\u3c/em\u3e [PDF]

, 2009
In an effort to probe the structure, mechanism, and biochemical properties of metallo-β-lactamase Bla2 from Bacillus anthracis, the enzyme was overexpressed, purified, and characterized.
Bender, Katherine M., Bennett, Brian, Breece, Robert M., Costello, Alison L., Crowder, Michael W., Hajdin, Christine E., Hawk, Megan J., Hu, Zhenxin, Tierney, David L.   +8 more
core   +2 more sources

Phosphonopeptides Revisited, in an Era of Increasing Antimicrobial Resistance [PDF]

, 2020
Given the increase in resistance to antibacterial agents, there is an urgent need for the development of new agents with novel modes of action. As an interim solution, it is also prudent to reinvestigate old or abandoned antibacterial compounds to assess
Anderson, Rosaleen, Bedernjak, Alexandre F., Cummings, Stephen P., Day, Kathryn M., Gray, Mark, Jones, Amanda L., Marrs, Emma C.L., Perry, John D., Varadi, Linda   +8 more
core   +2 more sources

MOESM2 of Whole genome sequencing uncovers a novel IND-16 metallo-β-lactamase from an extensively drug-resistant Chryseobacterium indologenes strain J31

, 2016
Additional files 2: Table S2. Numerous antibiotic resistance genes predicted in the C. indologenes J31 genome.
Tingting Wang, Xiawei Jiang, Chunyan Feng, Li, Ang, Huihui Dong, Shaoqiang Wu, Beiwen Zheng   +6 more
openaire   +1 more source

Validation of Hexaplex Recombinase Polymerase Amplification Assay for the Detection of Carbapenemase Genes in Klebsiella pneumoniae Isolates From Pediatric Inpatients

Journal of Clinical Laboratory Analysis, Volume 40, Issue 4, February 2026.
A novel hexaplex recombinase polymerase amplification (RPA) method was developed to rapidly and accurately detect five key carbapenemase genes and a Klebsiella pneumoniae‐specific target in a single reaction. This makes it an effective tool for CRKP detection in resource‐constrained environments.
Suthawan Mutitanon, Nuntaree Chaichanawongsaroj   +1 more
wiley   +1 more source

Additional file 1: Table S1. of Structure, Genetics and Worldwide Spread of New Delhi Metallo-β-lactamase (NDM): a threat to public health

, 2017
Worldwide distribution of NDM producing bacteria, as per articles available on PubMed database in the time period of Dec 2013 to Feb 2017. (PDF 136Â kb)
Khan, Asad, Maryam, Lubna, Zarrilli, Raffaele   +2 more
openaire   +1 more source

Inhibitory Potential of Polyclonal Camel Antibodies against New Delhi Metallo-β-lactamase-1 (NDM-1)

Molecules, 2020
New Delhi Metallo-β-lactamase-1 (NDM-1) is the most prevalent type of metallo-β-lactamase, able to hydrolyze almost all antibiotics of the β-lactam group, leading to multidrug-resistant bacteria.
Rahma Ben Abderrazek, Sarra Chammam, Ayoub Ksouri, Mariagrazia Perilli, Sayda Dhaouadi, Ines Mdini, Zakaria Benlasfar, Gianfranco Amicosante, Balkiss Bouhaouala-Zahar, Alessandra Piccirilli   +9 more
doaj   +1 more source

Prevalence of metallo-β-lactamase acquired genes among carbapenems susceptible and resistant Gram-negative clinical isolates using multiplex PCR, Khartoum hospitals, Khartoum Sudan

BMC Infectious Diseases, 2018
BackgroundThe increased prevalence of carbapenem-resistant Gram-negative isolates caused by Metallo-β-lactamase (MBL) is worrisome in clinical settings worldwide.
M. A. Adam, W. Elhag
semanticscholar   +1 more source

The Burden of Antimicrobial‐Resistant Pseudomonas aeruginosa Isolates in Children With Cystic Fibrosis: Molecular Characterization and Genotyping Analysis

MicrobiologyOpen, Volume 15, Issue 1, February 2026.
This study highlights the prevalence of multidrug‐ and carbapenem‐resistant Pseudomonas aeruginosa in pediatric cystic fibrosis patients, along with the presence of carbapenemase‐encoding genes and genetic profiles, suggesting clonal spread. These findings underscore the urgent need for surveillance and strategies to combat resistant strains and ...
Erfaneh Jafari, Babak Pourakbari, Mohammad Reza Asadi Karam, Reza Azizian, Mohammad Reza Modaresi, Setareh Mamishi   +5 more
wiley   +1 more source

Mechanisms involved in acquisition of blaNDM genes by IncA/C2 and IncFIIY plasmids [PDF]

, 2016
blaNDM genes confer carbapenem resistance and have been identified on transferable plasmids belonging to different incompatibility (Inc) groups. Here we present the complete sequences of four plasmids carrying a blaNDM gene, pKP1-NDM-1, pEC2-NDM-3, pECL3-
Alikhan, Nabil-Fareed, Beatson, Scott A., Forde, Brian M., Partridge, Sally R., Paterson, David L., Petty, Nicola K., Sartor, Anna L., Schembri, Mark A., Sidjabat, Hanna E., Wailan, Alexander M., Walsh, Timothy R., Williamson, Deborah A., Yam, Wan Keat   +12 more
core   +2 more sources