Structure, Genetics and Worldwide Spread of New Delhi Metallo-β-lactamase (NDM): a threat to public health [PDF]
BMC Microbiology, 2017 BackgroundThe emergence of carbapenemase producing bacteria, especially New Delhi metallo-β-lactamase (NDM-1) and its variants, worldwide, has raised amajor public health concern.
Asad U. Khan, Lubna Maryam, R. Zarrilli
semanticscholar +3 more sources
BMC Infectious Diseases, 2009 Background There are limited choice of antimicrobial agents to treat infection with metallo-β-lactamase-producing Pseudomonas aeruginosa. We evaluate the antimicrobial effects of aztreonam alone, colistin alone and the 3-drug combination of aztreonam ...
Oie Shigeharu +4 more
doaj +2 more sources
Membrane-anchoring stabilizes and favors secretion of New Delhi Metallo-β-lactamase [PDF]
Nature Chemical Biology, 2016 Carbapenems, “last resort” β-lactam antibiotics, are inactivated by zinc-dependent metallo-β-lactamases (MBLs). The host innate immune response withholds nutrient metal ions from microbial pathogens by releasing metal-chelating proteins such as ...
L. González +5 more
semanticscholar +5 more sources
Evolution of Metallo-β-lactamases: Trends Revealed by Natural Diversity and in vitro Evolution [PDF]
Antibiotics, 2014 The production of β-lactamase enzymes is one of the most distributed resistance mechanisms towards β-lactam antibiotics. Metallo-β-lactamases constitute a worrisome group of these kinds of enzymes, since they present a broad spectrum profile, being able
María-Rocío Meini +2 more
doaj +5 more sources
Metallo-β-lactamase-mediated antimicrobial resistance and progress in inhibitor discovery.
Trends in Microbiology, 2023 Resistance to β-lactam antibiotics is rapidly growing, substantially due to the spread of serine-β-lactamases (SBLs) and metallo-β-lactamases (MBLs), which efficiently catalyse β-lactam hydrolysis.
Yongqiang Yang +5 more
semanticscholar +1 more source
Microorganisms, 2023 Among the various mechanisms that bacteria use to develop antibiotic resistance, the multiple expression of β-lactamases is particularly problematic, threatening public health and increasing patient mortality rates. Even if a combination therapy—in which
Bogdan M. Benin +7 more
doaj +1 more source
Therapeutic Options for Metallo-β-Lactamase-Producing Enterobacterales
Infection and Drug Resistance, 2021 The spread of metallo-β-lactamase (MBL)-producing Enterobacterales worldwide without the simultaneous increase in active antibiotics makes these organisms an urgent public health threat.
X. Tan +8 more
semanticscholar +1 more source
Novel metallo β-lactamase mediated by aShigella flexneriplasmid [PDF]
FEMS Microbiology Letters, 1998 Novel carbapenem-hydrolyzing beta-lactamase (newly named MET-1) encoded on a transferable plasmid pMS390 from Shigella flexneri JS19622 was purified. The molecular weight was 28,000 by SDS-PAGE and the isoelectric point was higher than 9.3. This beta-lactamase favorably hydrolyzed classical cephalosporins and oxyimino-cephalosporins rather than ...
K, O'Hara +4 more
openaire +2 more sources
Journal of Pure and Applied Microbiology, 2021 Acinetobacter species are gram negative non fermenters, which are important nosocomial pathogens involved in various outbreaks in hospitals due to widespread resistance to majority antibiotics.
N Ashwin Chitrabanu, Shrikara Mallya
doaj +1 more source
Structural basis of metallo-β-lactamase resistance to taniborbactam
Antimicrobial Agents and Chemotherapy, 2023 The design of inhibitors against metallo-β-lactamases (MBLs), the largest family of carbapenemases, has been a strategic goal in designing novel antimicrobial therapies.
Salvador I. Drusin +5 more
semanticscholar +1 more source