Results 71 to 80 of about 9,257 (139)

Insights of β‐Lactams Resistance in Klebsiella pneumoniae Clinical Isolates: A Focus on Molecular Identification of Drug Resistance

International Journal of Microbiology, Volume 2026, Issue 1, 2026.
Klebsiella pneumoniae is associated with high antimicrobial resistance and is commonly isolated from colonization and healthcare‐associated infections (HAIs). This study is aimed at developing and validating molecular assays to detect resistance genes belonging to the bla family in resistant K. pneumoniae isolates.
Lavouisier F. B. Nogueira, Marília S. Maia, Marco A. F. Clementino, Ila F. N. Lima, Jorge L. N. Rodrigues, Luciana V. C. Fragoso, Glairta S. Costa, Jose Q. S. Filho, Alexandre Havt, Deiziane V. S. Costa, Lyvia M. V. C. Magalhães, Dilza Silva, José K. Sousa, Aldo A. M. Lima, Divakar Sharma   +14 more
wiley   +1 more source

Bismuth antimicrobial drugs serve as broad-spectrum metallo-β-lactamase inhibitors

Nature Communications, 2018
Metallo-β-lactamases (MBL) are zinc containing enzymes that cause resistance to β-lactam antibiotics. Here the authors show that the anti-Helicobacter pylori drug colloidal bismuth subcitrate inhibits MBLs by displacing the zinc ions with Bi(III), which ...
Runming Wang, Tsz-Pui Lai, Peng Gao, Hongmin Zhang, Pak-Leung Ho, Patrick Chiu-Yat Woo, Guixing Ma, Richard Yi-Tsun Kao, Hongyan Li, Hongzhe Sun   +9 more
doaj   +1 more source

In House Rapid, Simple Multiple‐Locus Variable‐Number Tandem Repeat Analysis (MLVA): A Reliable Tool for Enterobacter hormaechei Genotyping

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
We developed a new MLVA protocol targeting eight VNTR loci for the rapid and cost‐effective surveillance of Enterobacter hormaechei. Tested on diverse clinical isolates, it showed a discriminatory power comparable to MLST and was able to distinguish some strains within the same sequence type.
Claire Guillermard, Audrey Baron, Philippe Bidet, Kevin La, Maud Gits‐Muselli, Céline Courroux, Célie Malaure, Laurent Dortet, André Birgy, Stéphane Bonacorsi   +9 more
wiley   +1 more source

Resistance to ceftazidime–avibactam and other new β-lactams in Pseudomonas aeruginosa clinical isolates: a multi-center surveillance study

Microbiology Spectrum
New β-lactam–β-lactamase inhibitor combinations represent last-resort antibiotics to treat infections caused by multidrug-resistant Pseudomonas aeruginosa.
Felice Valzano, Gianfranco La Bella, Teresa Lopizzo, Anna Curci, Laura Lupo, Elisabetta Morelli, Adriana Mosca, Marianna Marangi, Raffaela Melfitano, Tiziana Rollo, Rosella De Nittis, Fabio Arena   +11 more
doaj   +1 more source

Rectal Carriage of Sequence Type 307 Klebsiella pneumoniae High‐Risk Clone Harboring Multiple Carbapenemase Genes in Community Hospitals Gauteng, South Africa

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
Graphical presentation of rectal carriage of carbapenem‐resistant Klebsiella pneumoniae, highlighting ST307 high‐risk clone and IncX3 plasmid‐associated blaOXA‐181. This study highlights the threat linked to horizontal gene transfer of AMR genes by epidemic plasmids from Klebsiella pneumoniae high‐risk clones to other bacterial species.
Kafilat Taiwo Salvador‐Oke, Johann Pitout, Gisele Peirano, Kathy‐Anne Strydom, Chanel Kingsburgh, Marthie Ehlers, Marleen Kock   +6 more
wiley   +1 more source

"Golden Era of Antibiotics" - Coming to an end !!!

SRM Journal of Research in Dental Sciences, 2012
Resistance to antibiotics is increasing at an alarming rate. This is due to superbugs, producing heterogenous groups of enzymes, β-lactamases which inactivate β-lactam antibiotics and others as well.
V Vinodhini, T S Subashini, K S Sridevi Sangeetha, R Shivakumar, Nafeesa Iqbal   +4 more
doaj  

The mechanism of NDM-1-catalyzed carbapenem hydrolysis is distinct from that of penicillin or cephalosporin hydrolysis

Nature Communications, 2017
New Delhi metallo-β-lactamases (NDMs) hydrolyze almost all β-lactam antibiotics and pose a major public health threat. Here, the authors study the mechanism of NDM-1 catalyzed carbapenem hydrolysis and present the crystal structures of the enzyme ...
Han Feng, Xuehui Liu, Sheng Wang, Joy Fleming, Da-Cheng Wang, Wei Liu   +5 more
doaj   +1 more source

Stony Coral Tissue Loss Disease Results in Persistent Microbial‐Level Disturbances on Coral Reef Ecosystems

Environmental Microbiology Reports, Volume 17, Issue 6, December 2025.
Reef microbiomes before the arrival of stony coral tissue loss disease (vulnerable stage) during the outbreak (epidemic) and after (endemic). Microbial diversity, network metrics, and functional potential varied among apparently healthy corals and the surrounding water and sediments across the stages.
Stephanie M. Rosales, J. Grace Klinges, Abigail S. Clark, Erinn M. Muller, Lindsay K. Huebner   +4 more
wiley   +1 more source

Detection of metallo-β-lactamases-encoding genes among clinical isolates of Pseudomonas aeruginosa in a tertiary care hospital, Kathmandu, Nepal

BMC Research Notes, 2017
Objectives This study was carried out to determine the prevalence of metallo-β-lactamases (MBLs) producing Pseudomonas aeruginosa in imipenem-nonsusceptible isolates and to detect MBL-encoding genes among MBLs-positive isolates.
Mahesh Acharya, Prabhu R. Joshi, Kamal Thapa, Rajan Aryal, Trishna Kakshapati, Supriya Sharma   +5 more
doaj   +1 more source

Metallo-β-Lactamase Inhibitors Inspired on Snapshots from the Catalytic Mechanism

Biomolecules, 2020
β-Lactam antibiotics are the most widely prescribed antibacterial drugs due to their low toxicity and broad spectrum. Their action is counteracted by different resistance mechanisms developed by bacteria.
Antonela R. Palacios, María-Agustina Rossi, Graciela S. Mahler, Alejandro J. Vila   +3 more
doaj   +1 more source