Results 81 to 90 of about 9,257 (139)

Protein determinants of dissemination and host specificity of metallo-β-lactamases

Nature Communications, 2019
Metallo-β-lactamases (MBLs) confer resistance to carbapenem antibiotics. Here, López et al. show that the host range of MBLs depends on the efficiency of MBL signal peptide processing and secretion into outer membrane vesicles, which affects bacterial ...
Carolina López, Juan A. Ayala, Robert A. Bonomo, Lisandro J. González, Alejandro J. Vila   +4 more
doaj   +1 more source

A Novel β-lactam/β-lactamase Inhibitor: Ceftolozane/tazobactam

Mediterranean Journal of Infection, Microbes and Antimicrobials, 2019
Ceftolozane/tazobactam is a novel generation cephalosporin and β-lactamase inhibitor combination antibiotic. It was approved for the treatment of adults (18 years and older) with complicated intraabdominal infections used in combination with ...
Kıvanç ŞEREFHANOĞLU
doaj   +1 more source

Post-Transplant Fecal Carriage of Antibiotic Resistant and β-Lactamases-Producing Enterobacteriales among Renal Transplant Recipients

Journal of Nepal Health Research Council
Background: The intestinal colonization and transmission of antibiotic-resistant Enterobacteriales to renal transplant recipients may pose a threat to them because they are profoundly immunocompromised and vulnerable to infection.
Bindira Joshi, Santosh Kumar Yadav, Manju Shree Shakya Hada, Sabina Shrestha, Kalpana Kumari Shrestha, Pukar Chandra Shrestha, Bal Krishna Awal   +6 more
doaj   +1 more source

A general reaction mechanism for carbapenem hydrolysis by mononuclear and binuclear metallo-β-lactamases

Nature Communications, 2017
Carbapenem-resistant bacteria pose a major health threat by expressing metallo-β-lactamases (MβLs), enzymes able to hydrolyse these life-saving drugs. Here the authors use biophysical and computational methods and show that different MβLs share the same ...
María-Natalia Lisa, Antonela R. Palacios, Mahesh Aitha, Mariano M. González, Diego M. Moreno, Michael W. Crowder, Robert A. Bonomo, James Spencer, David L. Tierney, Leticia I. Llarrull, Alejandro J. Vila   +10 more
doaj   +1 more source

An overview of the production of AmpC and Metallo-β-Lactamase enzymes in Escherichia coli [PDF]

Medical Laboratory Journal
Escherichia coli is a Gram-negative, rod-shaped bacterium, responsible for 90% of all community-acquired infections and 50% of hospital-acquired infections, with opportunistic infections found in intensive care unit (ICU) patients.
Kirandeep Kaur
doaj  

The role of aztreonam in rational antibacterial therapy of resistant nosocomial gram-negative infections. The new life for a well-known β-lactam

Медицина неотложных состояний
Background. The situation regarding the prevalence of resistant pathogens, types of β-lactamase products, and, accordingly, the justification of rational approaches to antibacterial therapy in Ukraine remains insufficiently studied.
V.A. Korsunov, M.A. Georgiyants, N.I. Zozulia, I.Yu. Odynets, M.B. Pushkar, M.V. Lyzogub, N.M. Bohuslavska, O.L. Onikiienko   +7 more
doaj   +1 more source

Strategies to Name Metallo-β-Lactamases and Number Their Amino Acid Residues. [PDF]

Antibiotics (Basel), 2023
Oelschlaeger P, Kaadan H, Dhungana R.
europepmc   +1 more source

Urinary tract infections caused by Gram-negative bacteria in elderly hospitalized patients: Epidemiology, clinical features and outcomes in the era of antimicrobial resistance

Journal of Global Antimicrobial Resistance
Objective: Urinary tract infections (UTI) are among the most common infections in elderly hospitalized patients, often caused by multi-drug resistant (MDR) organisms and characterized by poor clinical outcomes.
Gabriele Giuliano, Giulia Hankache, Margherita Sambo, Maria Grazia Cusi, Pietro Enea Lazzerini, Luigi Gennari, Massimiliano Fabbiani, Francesca Montagnani, Mario Tumbarello   +8 more
doaj   +1 more source

High in vitro activity of aztreonam/avibactam against NDM-producing Enterobacterales with emerging resistance in Escherichia coli in the United States Mid-Atlantic region

Microbiology Spectrum
New Delhi metallo-β-lactamase (NDM)-producing Enterobacterales represent a critical antimicrobial resistance threat with limited therapeutic options. Aztreonam/avibactam, which combines the stability of aztreonam against metallo-β-lactamases with the ...
Eetu Eklund, Tyler Maruca, Kate Kruczynski, Heather Critchfield, Robert Murphy, Eric Keller, Benjamin Lee, Ami Patel, Liore Klein, David A. Torpey, Robert A. Myers, Victoria L. Campodónico   +11 more
doaj   +1 more source

An Evaluation of Beta-Lactamase Prevalence and the Increasing Incidence of MBL in Gram-Negative Bacteria

Online Journal of Health & Allied Sciences
Purpose: β-lactamase mediated resistance mechanisms in gram-negative bacteria play a pivotal role in spreading antimicrobial resistance. We conducted this study to understand the prevalence of β-lactamases in Gram-negative bacteria in our region ...
Amrita Joshi, Suhas Nirkhiwale, Sheetal Bhasin, Aparna Tripathi   +3 more
doaj